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排序方式: 共有172条查询结果,搜索用时 31 毫秒
111.
Peng H Carrico D Thai V Blaskovich M Bucher C Pusateri EE Sebti SM Hamilton AD 《Organic & biomolecular chemistry》2006,4(9):1768-1784
A series of compounds based on the carboxyl-terminal CAAL sequence of PGGTase-I substrates was designed and synthesized. Using piperazin-2-one as a semi-rigid scaffold, we have introduced critical pharmacophores in a well-defined arrangement to mimic the CAAL sequence. High potency and exceptional selectivity were obtained for inhibition of PGGTase-I with structures such as 45 and 70. Potency of this series of GGTIs was dependent on the presence of an L-leucine residue with a free carboxyl terminus, as well as an S configuration of the 3-aryl group. The selectivity was significantly enhanced by 5-methyl substitution on the imidazole ring and fluorine substitution on the 3-aryl group. Modification of the 6-position of the piperazinone scaffold was found to be unfavorable. Compounds 44 and 69, the corresponding methyl esters of 45 and 70, were found to selectively block processing of Rap1A by PGGTase-I in whole cells with IC(50) values of 0.4 microM and 0.7 microM respectively. 相似文献
112.
Application of sample disruption methods in the extraction of anthocyanins from solid or semi-solid vegetable samples 总被引:6,自引:0,他引:6
Cassis, a commercial powder obtained from blackcurrant juice (Ribes nigrum L.), was used to optimize the anthocyanin extraction by matrix solid-phase dispersion (MSPD) and by sea sand disruption method (SSDM). The optimum eluent conditions were 5.0 mL of MeOH/H2O (1:1, v/v) at pH 2. The extracts were analyzed by HPLC with diode-array detection (DAD) and the extraction efficiency was evaluated by statistical comparison (analysis of variance, ANOVA-single factor) of the compounds peak areas. The extraction efficiency for the MSPD procedure was dependent on the chemical nature of the C18 material but the optimized procedure yielded results similar to those obtained by the inexpensive sea sand disruption method (SSDM). This procedure also compared favorably to a previously published liquid-liquid extraction method. The optimized sea sand method was then used in the anthocyanin extraction from red grapes (Vitis vinifera L.) and strawberries (Fragaria ananassa D.) yielding chromatographic profiles similar to those reported in the literature for these products. 相似文献
113.
Tatdotana Vacková Dora Kroisová Petr Špatenka 《Journal of Macromolecular Science: Physics》2013,52(1):68-76
The water desorption kinetics of polymer composite systems with hydrophilic cellulose fibers from recycled paper (PSP) filler embedded in various polymer matrices (hydrophobic thermoset epoxy resin [EP] and thermoplastic polypropylene [PP], and hydrophilic thermoplastic poly[vinyl alcohol] [PVA]) was studied. Polymer composites test pieces containing 0, 3, 6, 9, and 30 wt. % of fibers were prepared. Adhesion between fibers and polymer matrices was improved by utilization of maleic anhydride grafted polypropylene (MAPP) coupling agent in the case of thermoplastic matrices (both PP and PVA). Water desorption tests were conducted after immersing test pieces in a distilled water bath at room temperature for 24 h. Study of the water desorption kinetics proved the expected enhanced absorption of the resulting composites after incorporation of cellulose fibers. A difference between two similar types of PVA by measurement of the desorption kinetics was found. 相似文献
114.
Celina Love Jan Steinkühler David T. Gonzales Naresh Yandrapalli Tom Robinson Rumiana Dimova T.‐Y. Dora Tang 《Angewandte Chemie (International ed. in English)》2020,59(15):5950-5957
In situ, reversible coacervate formation within lipid vesicles represents a key step in the development of responsive synthetic cellular models. Herein, we exploit the pH responsiveness of a polycation above and below its pKa, to drive liquid–liquid phase separation, to form single coacervate droplets within lipid vesicles. The process is completely reversible as coacervate droplets can be disassembled by increasing the pH above the pKa. We further show that pH‐triggered coacervation in the presence of low concentrations of enzymes activates dormant enzyme reactions by increasing the local concentration within the coacervate droplets and changing the local environment around the enzyme. In conclusion, this work establishes a tunable, pH responsive, enzymatically active multi‐compartment synthetic cell. The system is readily transferred into microfluidics, making it a robust model for addressing general questions in biology, such as the role of phase separation and its effect on enzymatic reactions using a bottom‐up synthetic biology approach. 相似文献
115.
Challenges and rewards of the electrosynthesis of macroscopic aligned carbon nanotube array/conducting polymer hybrid assemblies
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Balazs Endrődi Gergely Ferenc Samu Dora Fejes Zoltan Németh Endre Horváth Andrea Pisoni Peter Krisztian Matus Klara Hernádi Csaba Visy Laszlo Forró Csaba Janáky 《Journal of Polymer Science.Polymer Physics》2015,53(21):1507-1518
Hybrid assemblies based on conducting polymers and carbon nanomaterials with organized nanoscale structure are excellent candidates for various application schemes ranging from thermal management to electrochemical energy conversion and storage. In the case of macroscopic samples, however, precise control of the nanoscale structure has remained a major challenge to be solved for the scientific community. In this study we demonstrate possible routes to homogeneously infiltrate poly(3‐hexylthiophene), poly(3,4‐ethylenedioxythiophene), and polyaniline into macroscopic arrays of vertically aligned multiwalled carbon nanotubes (MWCNTAs). Electron microscopic images and Raman spectroscopic analysis (performed along the longitudinal dimension of the hybrid samples) both confirmed that optimization of the electropolymerization circumstances allowed fine tuning of the hybrid structure towards the targeted application. In this vein, three different application avenues were tested. The remarkable anisotropy in both the electrical and thermal conductivity of the nanocomposites makes them eminently attractive candidates to be deployed in thermal management. Thermoelectric studies, aimed to understand the effect of organized nanoscale morphology on the important parameters (Seebeck coefficient, electrical‐, and thermal conductivity) compared to their non‐organized hybrid counterparts. Finally, extraordinary high charge storage capacity values were registered for the MWCNTA/PANI hybrids (500 F g?1 and 1–3 F cm?2). © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015 , 53, 1507–1518 相似文献
116.
Dora?MelucciEmail author Giuseppe?Chiavari Simona?Montalbani Silvia?Prati 《Journal of Thermal Analysis and Calorimetry》2011,104(2):415-421
Checking for the presence of egg in a painting layer allows to decide whether or not it is a tempera. Several already assessed
analytical techniques may be used to perform the chemical analysis for the detection of egg in paintings. As an advantageous
and alternative methodology for the determination of egg, a new application of analytical pyrolysis, hyphenated with gas chromatography–mass
spectrometry (GC–MS) system, in presence of hexamethyldisilazane (HMDS) and tetramethylammonium-hydroxide (TMAH), is reported
here. The innovation lays mainly in the choice of new markers for the presence of egg. It is here demonstrated that in art
diagnostic tris-TMS-ester and methyl ester of phosphoric acid, generated by the pyrolysis of standard phospholipids and synthetic
painting layers containing egg as binding medium, may be used as new markers for identification of egg in tempera layers.
The adoption of these new markers in analytical pyrolysis allows to obtain higher analytical performance with respect to classical
markers (fatty acids), especially in terms of yield and, as a consequence, in terms of limit of detection. 相似文献
117.
We investigate the dispersion property of space filling mode of photonic crystal structures and find a new type of dispersion—structure induced dispersion. By incorporating this new source of dispersion we designed PCF with large normal dispersion ~ 350 ps2/km. Our simulation indicates the dispersion of such fiber changes less than 3% in 1.4-1.7 μm wavelength range and we also show that our design is insensitive to the structure changes. 相似文献
118.
Naphthalene is degraded selectively in surfactant Triton X‐100 water solutions when treated with disperse TiO2 catalyst and UV‐B simulated solar light. After complete degradation of the naphthalene, degradation of the Triton X‐100 commences. The pseudo‐first‐order kobs values obtained for both naphthalene and Triton X‐100 decrease with increasing Triton X‐100 concentration. Experimental rate values fit the Langmuir–Hinshelwood equations. An apparent rate constant for naphthalene degradation kN = 17.3 ppm min?1 and an adsorption equilibrium constant kN = 0.009 ppm?1 are obtained from a plot of 1/kobs vs. naphthalene concentration. An apparent rate constant for Triton X‐100 degradation kT, calculated from a 1/kobs vs. Triton X‐100 concentration plot of 1.1 ppm/min, was obtained. Therefore, the selectivity observed in naphthalene vs. Triton X‐100 degradation is then due to the favorable naphthalene rate constant degradation that more than balances its unfavorable adsorption equilibrium on the TiO2 surface. This result is quite important to establish actual experimental conditions for treatment of sites contaminated with polyaromatic hydrocarbons (PAH). © 2005 Wiley Periodicals, Inc. Int J Chem Kinet 37: 414–419, 2005 相似文献
119.
An analytical procedure fit for the simultaneous determination of copper (II), chromium(VI), thallium(I), lead(II), tin(II), antimony(III), and zinc(II) by square wave anodic stripping voltammetry (SWASV) in three interdependent environmental matrices involved in foods and food chain as meals, cereal plants and soils is described. The digestion of each matrix was carried out using a concentrated HCl-HNO3-H2SO4 (meals and cereal plants) and HCl-HNO3 (soils) acidic attack mixtures. 0.1 mol/L dibasic ammonium citrate pH 8.5 was employed as the supporting electrolyte. The voltammetric measurements were carried out using, as working electrode, a stationary hanging mercury drop electrode (HMDE) and a platinum electrode and an Ag/AgCl/KClsat electrode as auxiliary and reference electrodes, respectively. The analytical procedure was verified by the analyses of the standard reference materials: Wholemeal BCR-CRM 189, Tomato Leaves NIST-SRM 1573a and Montana Soil Moderately Elevated Traces NIST-SRM 2711. For all the elements in the certified matrix, the precision as repeatability, expressed as relative standard deviation (Sr %) was lower than 5%. The accuracy, expressed as percentage relative error (e %) was of the order of 3-7%, while the detection limits were in the range 0.015-0.103 microg/g. Once set up on the standard reference materials, the analytical procedure was transferred and applied to commercial meal samples, cereal plants and soils samples drawn in sites devoted to agricultural practice. A critical comparison with spectroscopic measurements is also discussed. 相似文献
120.