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741.
Matthew Mann Joseph Kolis Don VanDerveer 《Acta Crystallographica. Section C, Structural Chemistry》2009,65(5):i27-i29
Potassium scandium niobate hydroxide, K3(Sc0.875Nb0.125)Nb2O9H1.75, is a new scandium niobate with a unique cage structure. The structure contains two non‐equivalent K+ sites (3m and m2 site symmetry), one disordered Sc3+/Nb5+ site (m site symmetry), one Nb5+ site (3m site symmetry), two O2− sites (m and mm2 site symmetry) and one H+ site (m site symmetry). Both scandium and niobium have octahedral environments, which combine to form cages around potassium. One K atom lies in a cube‐like cage built of seven octahedra, while the other K atom is encapsulated by an eight‐membered trigonal face‐bicapped prism. The cages form sheets that extend along the ab plane. 相似文献
742.
A posteriori error analysis of a cell-centered finite volume method for semilinear elliptic problems
Don Estep Michael Pernice Du Pham Simon Tavener Haiying Wang 《Journal of Computational and Applied Mathematics》2009,233(2):459-472
In this paper, we conduct a goal-oriented a posteriori analysis for the error in a quantity of interest computed from a cell-centered finite volume scheme for a semilinear elliptic problem. The a posteriori error analysis is based on variational analysis, residual errors and the adjoint problem. To carry out the analysis, we use an equivalence between the cell-centered finite volume scheme and a mixed finite element method with special choice of quadrature. 相似文献
743.
Müller T Johann L Jannack B Brückner M Lanfranchi DA Bauer H Sanchez C Yardley V Deregnaucourt C Schrével J Lanzer M Schirmer RH Davioud-Charvet E 《Journal of the American Chemical Society》2011,133(30):11557-11571
Our work on targeting redox equilibria of malarial parasites propagating in red blood cells has led to the selection of six 1,4-naphthoquinones, which are active at nanomolar concentrations against the human pathogen Plasmodium falciparum in culture and against Plasmodium berghei in infected mice. With respect to safety, the compounds do not trigger hemolysis or other signs of toxicity in mice. Concerning the antimalarial mode of action, we propose that the lead benzyl naphthoquinones are initially oxidized at the benzylic chain to benzoyl naphthoquinones in a heme-catalyzed reaction within the digestive acidic vesicles of the parasite. The major putative benzoyl metabolites were then found to function as redox cyclers: (i) in their oxidized form, the benzoyl metabolites are reduced by NADPH in glutathione reductase-catalyzed reactions within the cytosols of infected red blood cells; (ii) in their reduced forms, these benzoyl metabolites can convert methemoglobin, the major nutrient of the parasite, to indigestible hemoglobin. Studies on a fluorinated suicide-substrate indicate as well that the glutathione reductase-catalyzed bioactivation of naphthoquinones is essential for the observed antimalarial activity. In conclusion, the antimalarial naphthoquinones are suggested to perturb the major redox equilibria of the targeted infected red blood cells, which might be removed by macrophages. This results in development arrest and death of the malaria parasite at the trophozoite stage. 相似文献
744.
Barriuso J Nguyen DT Li JW Roberts JN MacNevin G Chaytor JL Marcus SL Vederas JC Ro DK 《Journal of the American Chemical Society》2011,133(21):8078-8081
Lovastatin, a cyclic nonaketide from Aspergillus terreus, is a hypercholesterolemic agent and a precursor to simvastatin, a semi-synthetic cholesterol-lowering drug. The biosynthesis of the lovastatin backbone (dihydromonacolin L) and the final 2-methylbutyryl decoration have been fully characterized. However, it remains unclear how two central reactions are catalyzed, namely, introduction of the 4a,5-double bond and hydroxylation at C-8. A cytochrome P450 gene, lovA, clustered with polyketide synthase lovB, has been a prime candidate for these reactions, but inability to obtain LovA recombinant enzyme has impeded detailed biochemical analyses. The synthetic codon optimization and/or N-terminal peptide replacement of lovA allowed the lovA expression in yeast (Saccharomyces cerevisiae). Both in vivo feeding and in vitro enzyme assays showed that LovA catalyzed the conversion of dihydromonacolin L acid to monacolin L acid and monacolin J acid, two proposed pathway intermediates in the biosynthesis of lovastatin. LovA was demonstrated to catalyze the regio- and stereo-specific hydroxylation of monacolin L acid to yield monacolin J acid. These results demonstrate that LovA is the single enzyme that performs both of the two elusive oxidative reactions in the lovastatin biosynthesis. 相似文献
745.
McDermott TC Akter T MacElroy JM Mooney DA McCann MT Dowling DP 《Langmuir : the ACS journal of surfaces and colloids》2012,28(1):506-516
In this work the origin of permselectivity in dense silica films which possess a pore structure with pore sizes commensurate with the molecular size of the diffusing gas species is investigated. Much of the recently reported work in this field has involved the development of composite membrane films, and while it is generally assumed that the transport process of the gas species within the selective layer of these films is activated in nature, there are anomalies with this simplified picture. In this paper a new model is developed which, for the first time, explains the permselective behavior of the thin selective coatings ubiquitous to membrane separation processes. The model involves the existence of two primary transport domains within the solid film, one of which rapidly conducts the permeating gas (under non-Fickian conditions), while the second domain involves a slow diffusion mode characterized by normal Fickian transport. To validate the model, molecular dynamics simulations are conducted for diffusion of a number of simple gases (He, N(2), and CO(2)) within silica glasses over a range of solid densities. The silica media employed in these studies are based on a novel approach developed in this work for the construction of three-dimensionally periodic atomistic structures of silica of arbitrary density in which network bond connectivity is ensured. The results obtained from this work are in qualitative agreement with experimental observations and confirm the existence of dual mode transport which is central to the interpretation of the permselectivity in composite membranes systems. 相似文献
746.
How can a formulator have confidence that a preservative system will perform as expected under adverse conditions? Extreme conditions that can lead to the development of "off odors" in the product can be a serious challenge for companies providing home care products in the global market. Formulation and stability testing occur under controlled parameters that simulate limited environmental conditions and microbial challenges are typically performed with a standard inoculum level. While this is an acceptable and dependable process, it does not necessarily assess how well a preservative system can perform under extreme environmental conditions or against unusually high levels of bacterial challenges. This is especially true when formulations are diluted and stored by the end-user. By modifying microbial challenge testing of a liquid dishwashing product to include unexpected dilution schemes, increased microbial assaults, and elevated temperatures, a pattern of preservative efficacy was established. The resulting approach proved to be a useful tool when developing use directions, recommended dilution levels, the overall surfactant system, preservative type, and storage restrictions. 相似文献
747.
Wright RJ Zhang W Yang X Fasulo M Tilley TD 《Dalton transactions (Cambridge, England : 2003)》2012,41(1):73-82
Proposed electrocatalytic proton reduction intermediates of hydrogenase mimics were synthesized, observed, and studied computationally. A new mechanism for H(2) generation appears to involve Fe(2)(CO)(6)(1,2-S(2)C(6)H(4)) (3), the dianions {[1,2-S(2)C(6)H(4)][Fe(CO)(3)(μ-CO)Fe(CO)(2)](2-) (3(2-)), the bridging hydride {[1,2-S(2)C(6)H(4)][Fe(CO)(3)(μ-CO)(μ-H)Fe(CO)(2)]}(-), 3H(-)(bridging), and the terminal hydride 3H(-)(term-stag), {[1,2-S(2)C(6)H(4)][HFe(CO)(3)Fe(CO)(3)]}(-), as intermediates. The dimeric sodium derivative of 3(2-), {[Na(2)(THF)(OEt(2))(3)][3(2-)]}(2) (4) was isolated from reaction of Fe(2)(CO)(6)(1,2-S(2)C(6)H(4)) (3) with excess sodium and was characterized by X-ray crystallography. It possesses a bridging CO and an unsymmetrically bridging dithiolate ligand. Complex 4 reacts with 4 equiv. of triflic or benzoic acid (2 equiv. per Fe center) to generate H(2) and 3 in 75% and 60% yields, respectively. Reaction of 4 with 2 equiv. of benzoic acid generated two hydrides in a 1.7 : 1 ratio (by (1)H NMR spectroscopy). Chemical shift calculations on geometry optimized structures of possible hydride isomers strongly suggest that the main product, 3H(-)(bridging), possesses a bridging hydride ligand, while the minor product is a terminal hydride, 3H(-)(term-stag). Computational studies support a catalytic proton reduction mechanism involving a two-electron reduction of 3 that severs an Fe-S bond to generate a dangling thiolate and an electron rich Fe center. The latter iron center is the initial site of protonation, and this event is followed by protonation at the dangling thiolate to give the thiol thiolate [Fe(2)H(CO)(6)(1,2-SHSC(6)H(4))]. This species then undergoes an intramolecular acid-base reaction to form a dihydrogen complex that loses H(2) and regenerates 3. 相似文献
748.
We introduce the novel method of self-propelling slugs for the biosample delivery for the application of a microcantilever biosensor. By implementing a surface patterned microstructure with a hydrophobic SU8 barrier, we demonstrated a top plate-less channel for biosample delivery without external electrokinetic force or pressure-driven flows. With a simply-patterned hydrophobic layer both on SiO2 and Au surfaces, which was favourably used for the biosensor surface, we were able to drive PBS solutions onto cantilever sensors by capillary actions. The measured flow velocity of the SU8 barrier with SiO2 surface reveals a linear increase with barrier height. With the Au bottom surface, we observed that the flow velocity is inversely proportional to channel width, at approximately 100 μm, while proportional linearly below 100 μm. The present micro-patterned structure integrated with microcantilever could help us with the ease of integrating the fluidic channel as well as multiplexing for bio/chemical sensors. 相似文献
749.
This paper provides extensions to procedures for the implementation of two well‐known term structure models. In the first part, a misleading implication given in two textbooks concerning the ability to fit a Ho–Lee type term structure tree through trial and error is corrected, and it is shown that the tree can be fitted precisely with a simple and easily programmable formula. In the second part, a previously published result that obtains the drift for a single‐factor discrete time Heath–Jarrow–Morton model is extended to a multi‐factor world. In both cases numerical examples are provided. 相似文献
750.
Analysis of a combined tip-tilt and deformable mirror 总被引:1,自引:0,他引:1
A deformable mirror mounted on a two-axis tilt platform can provide wavefront compensation at a single location in an adaptive optics system, resulting in a significant reduction in the number of optical components in the system and in a simplification of the alignment. However, the moment of inertia of a deformable mirror is significantly different from that of the monolithic mirror commonly mounted on a tilt platform. We report on what are to our knowledge the first experimental results of mounting a microelectromechanical deformable mirror onto a fast steering platform and the first observation that at low operating frequencies high-order deformation of the deformable mirror membrane was not recorded. 相似文献