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81.
Agata G?uszyńska Kamila Bajor Izabella Czerwińska Dominika Kalet Bernard Juskowiak 《Tetrahedron letters》2010,51(41):5415-5418
Two new ligands based on anthracene or carbazole planar skeletons, and a phenyloxazoline moiety linked by a vinyl bridge are synthesized as potential DNA-interacting drugs. Their spectral characteristics and DNA binding affinity are assessed. 相似文献
82.
Dominika B. Bernert Kathrin Isenbügel Helmut Ritter 《Journal of inclusion phenomena and macrocyclic chemistry》2012,72(1-2):241-246
This study demonstrates the protein stabilization of gelatin through supramolecular interactions of silica nanoparticles and the influence on the point of denaturation. The phenomenon was studied in diluted solutions by dynamic light scattering, viscosity measurements, and differential scanning calorimetry. Native gelatin is stabilized by cyclodextrin functionalized SiO2 nanoparticles. After heating, increased supramolecular interactions of the nanoparticles with the denaturated gelatin coils are observed by progressive agglomeration. The described observation also resulted in a melting temperature shift from 30 °C, for native gelatin, to about 47 °C for the gelatin/CD-SiO2, which indicates the supramolecular stabilization of the gelatin chain structure. It was found that the gelatin is supramolecularly immobilized on the nanoparticle up to a certain temperature through complexation by cyclodextrin. The described results, also confirmed by DSC and viscosity measurements, show the prospect of using cyclodextrin-modified surfaces for the immobilization of the proteins. 相似文献
83.
Urszula Śliwińska Florian P. Pruchnik Stanisław Ułaszewski Małgorzata Latocha Dominika Nawrocka-Musiał 《Polyhedron》2010
Reaction of dimers [M(η5-C5Me5)Cl2]2 (M-Rh, Ir) with quinolin-8-ol in molar ratio 1:2 leads to formation of monomer complexes [Rh(η5-C5Me5)Cl(qol)] (1) and [Ir(η5-C5Me5)Cl(qol)] (2) (qol = quinolin-8-olate). Compounds 1 and 2 have been characterized with elemental analysis and spectroscopic methods. 1H NMR spectra revealed that quinolin-8-olate is coordinated via oxygen and nitrogen atoms. The 1H NMR and 13C NMR spectra showed that carbon and hydrogen atoms of pentamethylcyclopentadienyl ligand are equivalent. The structure of rhodium complex has been calculated using DFT B3LYP method. The calculated geometry of complex 1 agrees very well with data found for rhodium complexes containing Cl, C5Me5 and qol ligands. Both complexes are active antitumor and antibacterial agents. 相似文献
84.
Dominika Bratkowska Arlene Davies Núria Fontanals Peter A.G. Cormack Francesc Borrull David C. Sherrington Rosa M. Marcé 《Journal of separation science》2012,35(19):2621-2628
Two novel high‐specific surface area polymeric sorbents (HXLPP‐SAXa and HXLPP‐SAXb) were synthesised and evaluated as solid‐phase extraction sorbents. The novel sorbents under study are based on hypercrosslinked polymer microspheres and designed specifically to offer ion‐exchange properties; the specific polymers of interest in the current work have been chemically modified in such a way as to impart a tuneable level of strong anion‐exchange character onto the sorbents. The novel sorbents were applied as strong anion‐exchange sorbents in solid‐phase extraction studies, with the goal being to selectively extract a group of acidic compounds from complex environmental samples in an efficient manner. Out of two HXLPP‐SAX resins evaluated in this study, it was found that the sorbent with the lower ion‐exchange capacity (HXLPP‐SAXa) gave rise to the best overall performance characteristics and, indeed, was found to compare favourably to the solid‐phase extraction performance of commercial strong anion‐exchange sorbents. When the HXLPP‐SAXa sorbent was applied to the solid‐phase extraction of environmental water samples, the result showed quantitative and selective extraction of low levels of acidic pharmaceuticals from 500 mL of river water and 100 mL of effluent wastewater. 相似文献
85.
In the search for new inhibitors of cholinesterases, a simple heterocyclic fusion reaction of isatoic anhydride 8 and 3,4-dihydroisoquinoline 22 was discovered which involves a spontaneous dehydrogenation upon heating. Applying the reaction, the bioactive natural alkaloid rutaecarpine and several substituted derivatives out of tryptamines and anthranilic acids or isatoic anhydrides, respectively, can be synthesized without tedious chromatographic purification. This provides simple and fast access to larger amounts of compounds with this privileged structure in medicinal chemistry. 相似文献
86.
Dominika Lesnicki Zhen Zhang Mischa Bonn Marialore Sulpizi Ellen H. G. Backus 《Angewandte Chemie (International ed. in English)》2020,59(31):13116-13121
We investigate the dynamics of water in contact with solid calcium fluoride, where at low pH, localized charges can develop upon fluorite dissolution. We use 2D surface‐specific vibrational spectroscopy to quantify the heterogeneity of the interfacial water (D2O) molecules and provide information about the sub‐picosecond vibrational‐energy‐relaxation dynamics at the buried solid/liquid interface. We find that strongly H‐bonded OD groups, with a vibrational frequency below 2500 cm?1, display very rapid spectral diffusion and vibrational relaxation; for weakly H‐bonded OD groups, above 2500 cm?1, the dynamics slows down substantially. Atomistic simulations based on electronic‐structure theory reveal the molecular origin of energy transport through the local H‐bond network. We conclude that strongly oriented H‐bonded water molecules in the adsorbed layer, whose orientation is pinned by the localized charge defects, can exchange vibrational energy very rapidly due to the strong collective dipole, compensating for a partially missing solvation shell. 相似文献
87.
Dominika Veselinyov Jana Malankov Katarina Kalinov Helena Mi
kov Mria Marekov Miroslava Rabajdov 《Molecules (Basel, Switzerland)》2021,26(13)
We are experiencing rapid progress in all types of imaging techniques used in the detection of various numbers and types of mutation. In situ hybridization (ISH) is the primary technique for the discovery of mutation agents, which are presented in a variety of cells. The ability of DNA to complementary bind is one of the main principles in every method used in ISH. From the first use of in situ techniques, scientists paid attention to the improvement of the probe design and detection, to enhance the fluorescent signal intensity and inhibition of cross-hybrid presence. This article discusses the individual types and modifications, and is focused on explaining the principles and limitations of ISH division on different types of probes. The article describes a design of probes for individual types of in situ hybridization (ISH), as well as the gradual combination of several laboratory procedures to achieve the highest possible sensitivity and to prevent undesirable events accompanying hybridization. The article also informs about applications of the methodology, in practice and in research, to detect cell to cell communication and principles of gene silencing, process of oncogenesis, and many other unknown processes taking place in organisms at the DNA/RNA level. 相似文献
88.
Longfei Yu Eliza Harris Dominika Lewicka-Szczebak Matti Barthel Margareta R.A. Blomberg Stephen J. Harris Matthew S. Johnson Moritz F. Lehmann Jesper Liisberg Christoph Müller Nathaniel E. Ostrom Johan Six Sakae Toyoda Naohiro Yoshida Joachim Mohn 《Rapid communications in mass spectrometry : RCM》2020,34(20):e8858
The isotopic composition of nitrous oxide (N2O) provides useful information for evaluating N2O sources and budgets. Due to the co-occurrence of multiple N2O transformation pathways, it is, however, challenging to use isotopic information to quantify the contribution of distinct processes across variable spatiotemporal scales. Here, we present an overview of recent progress in N2O isotopic studies and provide suggestions for future research, mainly focusing on: analytical techniques; production and consumption processes; and interpretation and modelling approaches. Comparing isotope-ratio mass spectrometry (IRMS) with laser absorption spectroscopy (LAS), we conclude that IRMS is a precise technique for laboratory analysis of N2O isotopes, while LAS is more suitable for in situ/inline studies and offers advantages for site-specific analyses. When reviewing the link between the N2O isotopic composition and underlying mechanisms/processes, we find that, at the molecular scale, the specific enzymes and mechanisms involved determine isotopic fractionation effects. In contrast, at plot-to-global scales, mixing of N2O derived from different processes and their isotopic variability must be considered. We also find that dual isotope plots are effective for semi-quantitative attribution of co-occurring N2O production and reduction processes. More recently, process-based N2O isotopic models have been developed for natural abundance and 15N-tracing studies, and have been shown to be effective, particularly for data with adequate temporal resolution. Despite the significant progress made over the last decade, there is still great need and potential for future work, including development of analytical techniques, reference materials and inter-laboratory comparisons, further exploration of N2O formation and destruction mechanisms, more observations across scales, and design and validation of interpretation and modelling approaches. Synthesizing all these efforts, we are confident that the N2O isotope community will continue to advance our understanding of N2O transformation processes in all spheres of the Earth, and in turn to gain improved constraints on regional and global budgets. 相似文献
89.
90.
One‐day pulsed‐field gel electrophoresis protocol for rapid determination of emetic Bacillus cereus isolates
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Paulina S. Kaminska Krzysztof Fiedoruk Dominika Jankowska Jacques Mahillon Karol Nowosad Ewa Drewicka Monika Zambrzycka Izabela Swiecicka 《Electrophoresis》2015,36(7-8):1051-1054
Bacillus cereus, the Gram‐positive and spore‐forming ubiquitous bacterium, may cause emesis as the result of food intoxication with cereulide, a heat‐stable emetic toxin. Rapid determination of cereulide‐positive B. cereus isolates is of highest importance due to consequences of this intoxication for human health and life. Here we present a 1‐day pulsed‐field gel electrophoresis for emetic B. cereus isolates, which allows rapid and efficient determination of their genomic relatedness and helps determining the source of intoxication in case of outbreaks caused by these bacilli. 相似文献