排序方式: 共有149条查询结果,搜索用时 15 毫秒
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ukasz Orze Maria Oszajca Justyna Polaczek Dominika Porbska Rudi van Eldik Grayna Stochel 《Molecules (Basel, Switzerland)》2021,26(16)
Pressure is one of the most important parameters controlling the kinetics of chemical reactions. The ability to combine high-pressure techniques with time-resolved spectroscopy has provided a powerful tool in the study of reaction mechanisms. This review is focused on the supporting role of high-pressure kinetic and spectroscopic methods in the exploration of nitric oxide bioinorganic chemistry. Nitric oxide and other reactive nitrogen species (RNS) are important biological mediators involved in both physiological and pathological processes. Understanding molecular mechanisms of their interactions with redox-active metal/non-metal centers in biological targets, such as cofactors, prosthetic groups, and proteins, is crucial for the improved therapy of various diseases. The present review is an attempt to demonstrate how the application of high-pressure kinetic and spectroscopic methods can add additional information, thus enabling the mechanistic interpretation of various NO bioinorganic reactions. 相似文献
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We propose a method for the modification of surfaces of microchannels in chips fabricated in polycarbonate (PC) that makes the devices resistant to a range of organic solvents. Coating of PC with branched polyethyleneimine (BPEI) with the use of trimethylpropane triglycidyl ether (TTE) as a linker renders the devices resistant to toluene, benzene, acetonitrile, tetrahydrofuran, dioxane and ethylene dichloride. The optimized procedure of modification allows for continuous operation of the chips for several hours without dissolution of PC. Additional modification with the use of Krytox? allows for the use of Fluorinert (FC-40) as the continuous phase and for generation and handling of droplets of organic solvents that are miscible with water. 相似文献
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We study how the orientation of the optic axis affects single-scattering properties for small, birefringent calcite particles simulated using DDSCAT 7.1.1. We consider two irregular model particles, a flake and a rhomboid, in either a (i)?fixed or (ii)?random orientation. Simulations are performed for three volume-equivalent radii of 0.1, 0.45, and 1.0?μm. For each target, we repeat the computations for three sets of orientations of the optic axis. When a fixed spatial orientation of the target is considered, the simulations are significantly affected by the orientation of the optic axis. However, the effect is considerably weaker when assuming the same targets in random spatial orientation. 相似文献
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ukasz Lewandowski Iwona Bednarz-Misa Alicja Z. Kucharska Agnieszka Kubiak Patrycja Kasprzyk Tomasz Sozaski Dominika Przybylska Narcyz Pirecki Magorzata Krzystek-Korpacka 《Molecules (Basel, Switzerland)》2022,27(13)
Despite the fact that phytochemicals of Cornaceae species have long been discussed as possible auxiliary agents in contemporary treatment, the insights on their properties remain relatively scarce. This study focuses on Cornus mas L. (Cornelian cherry), the extracts of which are reported to exert a pleiotropic effect shown in both in vivo and in vitro studies. This study aimed to explore the cytotoxic effect of extracts from fruits of red (Cornus mas L. ‘Podolski’) and yellow (Cornus mas L. ‘Yantarnyi’ and ‘Flava’) Cornelian cherries on two melanoma cell lines (A375 and MeWo). The extracts were characterized in the context of the concentration of bioactive compounds of antioxidative properties. Cytotoxicity was investigated with the use of the following two assays: SRB and MTT. An additional, alternative protocol for the SRB assay was used in this study so as to account for possible bias. Cytotoxicity was assessed as a difference in the whole time series of cell viability, instead of analyzing differences in raw values (often found in the literature). Both extracts from Cornus mas L. induced cytotoxicity in both A375 and MeWo cell lines, although the response of these cells was different. Moreover, based on this study, there is no evidence for claiming a different magnitude of cytotoxicity between these two extracts. 相似文献
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Dominika Kajszczak Agnieszka Kowalska-Baron Dorota Sosnowska Anna Podsdek 《Molecules (Basel, Switzerland)》2022,27(10)
One of the effective treatments for diabetes is to reduce and delay the absorption of glucose by inhibition of α-amylase and α-glucosidase in the digestive tract. Currently, there is a great interest in natural inhibitors from various part of plants. In the present study, the phenolic compounds composition of V. opulus bark and flower, and their inhibitory effects on in vitro potato starch digestion as well as on α-amylase and α-glucosidase, have been studied. Bark and flower phenolic extracts reduced the amount of glucose released from potato starch during tree-stage simulated digestion, with IC50 value equal to 87.77 µg/mL and 148.87 µg/mL, respectively. Phenolic bark extract showed 34.9% and 38.4% more potent inhibitory activity against α-amylase and α-glucosidase, respectively, but the activity of plant extracts was lower than that of acarbose. Chlorogenic acid (27.26% of total phenolics) and (+)-catechin (30.48% of total phenolics) were the most prominent phenolics in the flower and bark extracts, respectively. Procyanidins may be responsible for the strongest V. opulus bark inhibitory activity against α-amylase, while (+)-catechin relative to α-glucosidase. This preliminary study provides the basis of further examination of the suitability of V. opulus bark compounds as components of nutraceuticals and functional foods with antidiabetic activity. 相似文献
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Journal of Thermal Analysis and Calorimetry - This paper deals with the design, synthesis, hydration mechanism and hydration products of novel Ba2+-, Cu2+- or Bi3+-doped... 相似文献
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