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11.
Abdelghani Mahmoudi Silvia De Francia Prasanta Paul 《Journal of separation science》2023,46(21):2300424
Clarithromycin is a very important macrolide antibiotic used to treat bacterial infections in human and veterinary medicine. This study reports the development and validation of cost-effective, simple, precise, accurate, and robust high-performance liquid chromatography (HPLC) for the determination of clarithromycin (CLA) in tablets. Reversed-phase chromatography was conducted using a standard column at 55°C with ultraviolet detection at 215 nm. A mobile phase consisting of acetonitrile –2-methyl-2-propanol –potassium phosphate buffer was used at a flow rate of 1.0 mL/min. The proposed method displayed good linearity, precision, accuracy, robustness, and specificity. The present HPLC was compared with capillary electrophoresis and bioassay methods and the results indicated that there was no significant difference between these methods. Moreover, the obtained results demonstrated the validity of the isocratic HPLC, which allows reliable quantitation of CLA in pharmaceutical samples. Thus, it can be used as a substitute alternative methodology for the routine quality control of this medicine, in situations where other methods are less accessible in the laboratory. 相似文献
12.
Oualid Guemri Abdelghani Bekrar Bouziane Beldjilali Damien Trentesaux 《4OR: A Quarterly Journal of Operations Research》2016,14(4):377-404
In this paper, we introduce an improved Greedy Randomized Adaptive Search Procedure (GRASP) based heuristic for the multi-product multi-vehicle inventory routing problem (MMIRP). The inventory routing problem, which combines the vehicle-routing problem and the inventory control decisions, is one of the most important problems in combinatorial optimization field. To deal with the MMIRP, we develop a GRASP-based heuristic (GBH). Each GBH iteration consists of two sequential phases; the first phase is a Greedy Randomized Procedure, in which, the best tradeoff between the inventory holding cost and routing cost is looked. Then, in the second phase, as local search for the GRASP, we use the Tabu search (TS) meta-heuristic to improve the solution found in the first phase. The GBH two phases are repeated until some stopped criterion is met. Our proposed method is evaluated on two benchmark data sets, and successfully compared with two state-of-the-art algorithms. 相似文献
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Ahmed El Kharroubi Abdelhak Yaacoubi Abdelghani Ben Tahar Kawtar Bichard 《Queueing Systems》2012,70(4):299-337
In this paper we consider the variational problem in the non-negative orthant of ℝ3. The solution of this problem gives the large deviation rate function for the stationary distribution of an SRBM (Semimartingal
Reflecting Brownian Motion). Avram, Dai and Hasenbein (Queueing Syst. 37, 259–289, 2001) provided an explicit solution of this problem in the non-negative quadrant. Building on this work, we characterize reflective
faces of the non-negative orthant of ℝ
d
, we construct boundary influence cones and we provide an explicit solution of several constrained variational problems in ℝ3. Moreover, we give conditions under which certain spiraling paths to a point on an axis have a cost which is strictly less
than the cost of every direct path and path with two pieces. 相似文献
16.
H. Hillebrandt A. Abdelghani C. Abdelghani-Jacquin M. Aepfelbacher E. Sackmann 《Applied Physics A: Materials Science & Processing》2001,73(5):539-546
Impedance spectroscopy and phase-contrast microscopy are combined to monitor the electrical and morphological properties of
human umbilical vein endothelial cell monolayers. The cells were cultured on optically transparent indium-tin-oxide (ITO)
semiconductor electrode arrays coated with collagen IV, and the effect of the inflammatory mediator thrombin on monolayer
permeability was monitored in real time. ITO electrodes provide several advantages for these kinds of experiments, because
they are optically transparent, polarizable and highly sensitive due to the absence of insulating oxide layers. A qualitative
correlation between the thrombin-induced gap formation and the electrical parameters of the cell layer is established.
Received: 8 August 2000 / Accepted: 2 March 2001 / Published online: 20 June 2001 相似文献
17.
Kherroubi Seddik Benkahla Youb Khaled Labsi Nabila Ragui Karim Bensaci Abdelghani Boutra Abdelkader Ouyahia Seif-Eddine Benzema Mahdi 《Journal of Thermal Analysis and Calorimetry》2021,144(3):623-646
Journal of Thermal Analysis and Calorimetry - Through this paper, three-dimensional fluid flow and heat transfer of Al2O3 nanofluid within ventilated enclosures was taken into consideration.... 相似文献
18.
Boumeftah Ali Belmokhtar Abdelkader Benyoucef Abdelghani 《Research on Chemical Intermediates》2022,48(4):1717-1731
Research on Chemical Intermediates - Innovative hybrid composites based on poly (4,4'-Diaminodiphenyl sulfone) (PDDS) and TiO2 nanoparticles have been synthesized. The samples have been... 相似文献
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Abdelghani Zeghib 《Mathematische Zeitschrift》1998,227(2):245-262
20.
Narain R Housni A Gody G Boullanger P Charreyre MT Delair T 《Langmuir : the ACS journal of surfaces and colloids》2007,23(26):12835-12841
We report here the preparation of novel biotinylated glyconanoparticles from well-defined biotinylated glycopolymers and poly(N-isopropylacrylamide) (PNIPAAm) synthesized via the reversible addition fragmentation chain transfer (RAFT) polymerization process. The in situ reduction of the biotinylated glycopolymers, PNIPAAm, poly(ethylene glycol), and HAuCl4 via a photochemical process resulted in the formation of biotinylated gold nanoparticles. The multifunctional biotinylated glyconanoparticles were then evaluated for their bioconjugation toward streptavidin using UV-vis spectroscopy and surface plasmon resonance (SPR). The biotinylated nanoparticles underwent aggregation in the presence of streptavidin as revealed by spectrophotometry, which indicates the accessibility of the biotin for conjugation. These results were further confirmed by surface plasmon resonance even in the case of surface-immobilized streptavidin. 相似文献