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41.
42.
Chiral discrimination and recognition is important in peptide biosynthesis, amino acid synthesis and drug designing. Detailed
structural information is available about the peptide synthesis in ribosome. However, no detailed study is available about
the discrimination in peptide synthesis. We study the conformational energy variation of neutral methoxy phenyl alanine molecule
as a function of its different dihedral angle to locate the minimum energy conformation using quantum chemical theory. We
compared the intermolecular energy surfaces of phenyl alanine molecule in its neutral and zwitterionic state using quantum
chemical theory as a function of distance and mutual orientation. The energy surfaces are studied with rigid geometry by varying
the distance and orientation. The potential energy surfaces of L-L and D-L pairs are found to be dissimilar and reflect the underlying chirality of the homochiral pair and racemic nature of the heterochiral
pair. The intermolecular energy surface of homochiral pair is more favourable than the corresponding energy surface of heterochiral
pair. 相似文献
43.
We employ the hybrid soliton model of the nucleon consisting of a topological meson field and deeply bound quarks to investigate the behavior of the quarks on soliton matter as a function of density. We investigate a particular possible ground state by placing the solitons on a spatial lattice. The model suggests the transition of matter from a color insulator to a color conductor above a critical density of a few times normal nuclear density. 相似文献
44.
The oxide system Bi2.2Ca2.8−x
Sr
x
Cu2O
y
has been investigated for superconductivity as a function of Ca/Sr ratio withx=0.7, 1.0, 1.4 and 1.8. All these compositions are found to be superconducting with onset temperature in the range of 80–90
K implying a large homogeneity range between Sr and Ca for the superconductivity to occur in this system. Effect of partial
replacement of Bi by rare earths has been studied and it is observed that 20% replacement of Bi by Nd and Eu does not significantly
affect the superconducting transition temperature. 相似文献
45.
A path independent integral formula is developed for the computation of the intensity of the stress singularity at a right corner where one edge is rigidly fixed and the other is free of traction. Numerical results are presented for the case of a strip compressed between rough rigid stamps and compared with previously published results for finite and semi-infinite strips and cylinders. 相似文献
46.
A simple reversed-phase high-performance liquid chromatographic method employing C-18 column has been developed for simultaneous analysis of three intermediates in the synthesis of S-duloxetine, the antidepressant drug, viz., 2-acetyl thiophene (AT), N,N-dimethyl-3-keto-(2-thienyl)-propanamine (DKTP) and (S)-N,N-dimethyl-3-hydroxy-(2-thienyl)-propanamine (DHTP). Good separations were achieved by employing an isocratic system using acetonitrile and 0.05 M phosphate buffer (pH 7.0) containing 0.02% diethylamine. The detection was carried out at 241 nm. The method was validated for linearity, range, accuracy and precision. The developed method was applied for monitoring the progress of chemical synthesis of DKTP from AT followed by the biocatalytic reduction of DKTP to DHTP as the disappearance of the substrate and formation of the product can be monitored simultaneously by the present method. 相似文献
47.
Madhusudanan KP Kumar B Tiwari P Madhusudan SK Misra AK 《Journal of mass spectrometry : JMS》2005,40(1):25-35
The effect of metal cationization on the tandem mass spectra of glycosyl dithioacetals of glucose, mannose, galactose, rhamnose, arabinose and xylose was studied by electrospray ionization mass spectrometry under ammonium and metal (Li, Na, Ag and Cu) ion cationization conditions. The ammonium-cationized glycosyl dithioacetals fragment by loss of ammonia followed by either two molecules of EtSH or one molecule of EtSH and one molecule of H2O. Lithium cationization leads to additional eliminations such as EtSEt and EtSSEt and C-C cleavages. Elimination of EtSH is not observed under sodium cationization. Silver cationization, on the other hand, leads to additional fragmentations involving the elimination of silver as AgOH and AgSEt. Copper cationization results in adducts where copper has undergone a change of oxidation state from II to I. Li+, Ag+ and Cu+ cationization seem to favour cyclization resulting in elimination of EtSH. However, the mechanisms seem to be differently affected by different metal ions. Li+ and Ag+ cationization appear to be non-specific and favour cyclization involving C2-, C4- and C5-hydroxyl hydrogens, whereas Cu+ cationization seems to favour cyclization involving C4-hydroxyl hydrogen. 相似文献
48.
In view of an excellent agreement between the recently determinedv
μ-hadron couplings and predictions of the standard model, the basic question discussed is how far its neutral current predictions
can be mimiced in going either from the isodoublet to an isotriplet (or an even higher isospin) left-handed representation
or from SU
L
(2) × U(1) toG × U(1), whereG is a simple group of rank two. This question is addressed with reference to a sufficiently broad class of schemes. Their
most distinctive properties are: in the higher isospin scheme, neutrino couplings are precisely in the form obtainable with
standard l.h. representation; the higher g.g. scheme isL+R type in which, to each light fermion of evenRU parity, a superheavy fermion of the same charge and oddRU parity is associated, parity conservation forbidding their mixing. Reasons for excluding theL-type andG
2 higher g.g. schemes are given. Their neutral current predictions are compared with those of the standard model. A higher
isospin representation can mimic the predictions of the standard model in inclusive and semi-inclusivev
μ-hadron reactions but is conclusively discriminated from the isodoublet representation by elasticv
μ
(−
p scattering. TheG × U(1) scheme can mimic standard model neutrino sector but is conclusively discriminated from minimal scheme by parity violating
effects. 相似文献
49.
Rajinder K. Tuli Purshotam Soni Kailash Chandra Rajendra K. Sharma Bhagawan S. Garg 《Transition Metal Chemistry》1980,5(1):145-148
Summary
N,N-Dialkyldithiocarbametohafnium(IV) complexes of the type -CpHf(S2CNR2)3, (R = Me or Et) have been prepared in nonaqueous media by reacting dichlorodicyclopentadienylhafnium(IV) with sodium salts of substituted dithiocarbamic acids. Conductance and i.r. studies show that these complexes are nonelectrolytes in which all of the dithiocarbamate ligands are bidentate. A coordination number of seven may be assigned to hafnium(IV) in these complexes, 'H n.m.r. spectra of the complexes in CDCI3 at ambient temperature (30°) indicate that the metal centered rearrangement and the S2C N bond rotation are both slow on the n.m.r. time scale. A capped octahedron configuration is suggested for these complexes.Author to whore all correspondence should be addressed. 相似文献
50.
Walczak W Pipalia NH Soni M Faruqi AF Ralph H Maxfield FR Webb BL 《Combinatorial chemistry & high throughput screening》2006,9(9):711-718
The conversion of the genomic information produced by the recent sequencing projects into a comprehensive understanding of the human proteome has yet to occur. A new technology that represents a potential bridge between genomics and proteomics is reverse transfection. Reverse transfection cell microarrays are produced by overlaying cDNA arrays with mammalian cells, generating localized clusters of transfected cells with each cluster overexpressing a unique protein. This miniaturized cell-based microarray format affords parallel functional analysis of thousands of cDNA constructs in a high throughput format. In this report we document the development of a co-transfection methodology for reverse transfection applications. The demonstrated high co-transfection efficiency with a "marker" plasmid encoding for GFP enables the identification of transfected cells and eliminates the need for epitope-tagged constructs in cell-based high throughput screening applications using reverse transfection. This co-transfection method was used to study in parallel the structure/function of multiple versions of the v-Src protein using automated fluorescence microscopy. The wild-type v-Src protein and four mutants having insertions or deletions in the SH2 or SH3 domains displayed high levels of tyrosine kinase activity in HEK293T cells. Three other mutated v-Src proteins, including a kinase-dead version, were shown to be defective for tyrosine kinase activity. This reverse co-transfection approach is applicable for high throughput screening of both cDNA libraries and positional scanning recombinant protein libraries. 相似文献