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91.
Mathematical Programming - Decision rules provide a flexible toolbox for solving computationally demanding, multistage adaptive optimization problems. There is a plethora of real-valued decision... 相似文献
92.
We propose a novel robust optimization approach to analyze and optimize the expected performance of supply chain networks. We model uncertainty in the dema 相似文献
93.
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95.
Theocharakis P Glotsos D Kalatzis I Kostopoulos S Georgiadis P Sifaki K Tsakouridou K Malamas M Delibasis G Cavouras D Nikiforidis G 《Magnetic resonance imaging》2009,27(3):417-422
In this study, a pattern recognition system has been developed for the discrimination of multiple sclerosis (MS) from cerebral microangiopathy (CM) lesions based on computer-assisted texture analysis of magnetic resonance images. Twenty-three textural features were calculated from MS and CM regions of interest, delineated by experienced radiologists on fluid attenuated inversion recovery images and obtained from 11 patients diagnosed with clinically definite MS and from 18 patients diagnosed with clinically definite CM. The probabilistic neural network classifier was used to construct the proposed pattern recognition system and the generalization of the system to unseen data was evaluated using an external cross validation process. According to the findings of the present study, statistically significant differences exist in the values of the textural features between CM and MS: MS regions were darker, of higher contrast, less homogeneous and rougher as compared to CM. 相似文献
96.
Georgiadis P Cavouras D Kalatzis I Glotsos D Athanasiadis E Kostopoulos S Sifaki K Malamas M Nikiforidis G Solomou E 《Magnetic resonance imaging》2009,27(1):120-130
Three-dimensional (3D) texture analysis of volumetric brain magnetic resonance (MR) images has been identified as an important indicator for discriminating among different brain pathologies. The purpose of this study was to evaluate the efficiency of 3D textural features using a pattern recognition system in the task of discriminating benign, malignant and metastatic brain tissues on T1 postcontrast MR imaging (MRI) series. The dataset consisted of 67 brain MRI series obtained from patients with verified and untreated intracranial tumors. The pattern recognition system was designed as an ensemble classification scheme employing a support vector machine classifier, specially modified in order to integrate the least squares features transformation logic in its kernel function. The latter, in conjunction with using 3D textural features, enabled boosting up the performance of the system in discriminating metastatic, malignant and benign brain tumors with 77.14%, 89.19% and 93.33% accuracy, respectively. The method was evaluated using an external cross-validation process; thus, results might be considered indicative of the generalization performance of the system to "unseen" cases. The proposed system might be used as an assisting tool for brain tumor characterization on volumetric MRI series. 相似文献
97.
Panayiotis V. Ioannou Prof. Dr. Dimitris G. Vachliotis Theodore D. Sideris 《无机化学与普通化学杂志》2009,635(2):329-336
The reaction of Bunsen's cacodyl disulfide, Me2As(S)‐S‐AsMe2, with heavy metal cations in methanol produces insoluble salts (complexes) of dimethyldithioarsinic acid, Me2AsS2H, and dimethyl arsenium ion, Me2As:+. This arsenium ion prefers to react with Me2As(S)‐S‐AsMe2, when in excess, compared to AcO? or MeOH/H2O and it is also reactive towards sulfur (Sx, x = 1‐8) producing the stabilized dimethylarsino sulfenium cation, . The complexes (Me2AsS2)xM (x = 1 or 2) are unstable in the presence of their own heavy metal cations decomposing to colored solids. In an attempt to prepare salts of Me2AsSH, the reactions of (Me2AsS2)xM with triphenylphosphine and trimethyl phosphite gave the metal sulfide and Me2As‐S‐AsMe2 instead. 相似文献
98.
Alexandros G. Koutsioubas Nikolaos Spiliopoulos Dimitris L. Anastassopoulos Alexandros A. Vradis George D. Priftis 《Surface and interface analysis : SIA》2009,41(11):897-903
The formation process of n‐alkane phosphonic acid CH3 (CH2)n?1 PO(OH)2 (n = 10,12,14,18) self‐assembled monolayers (SAMs), deposited from ethanol solutions on aluminum oxide, has been monitored in situ using surface plasmon resonance (SPR) spectroscopy. In addition, the two‐solvent approach is used to obtain both film thickness and refractive index of the fully formed adsorbed layers. A densely packed adsorbed layer is formed only for the longest molecules with n = 18. The chain length and solution concentration dependence of formation kinetics are studied, and the existence of two distinct kinetic steps is revealed. Fittings of the experimental results with various kinetic models are performed. Our analysis suggests that during the first kinetic step, a transition from a lying‐down to a standing‐up phase takes place, and the growth of this standing‐up phase is governed by second‐order kinetics. The second slow kinetic step is described by a modified first‐order Langmuir law. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
99.
Arthur Berg Dimitris N. Politis 《Annals of the Institute of Statistical Mathematics》2009,61(2):477-498
Improved performance in higher-order spectral density estimation is achieved using a general class of infinite-order kernels.
These estimates are asymptotically less biased but with the same order of variance as compared to the classical estimators
with second-order kernels. A simple, data-dependent algorithm for selecting the bandwidth is introduced and is shown to be
consistent with estimating the optimal bandwidth. The combination of the specialized family of kernels with the new bandwidth
selection algorithm yields a considerably improved polyspectral estimator surpassing the performances of existing estimators
using second-order kernels. Bispectral simulations with several standard models are used to demonstrate the enhanced performance
with the proposed methodology. 相似文献
100.
The influenza virus surface glycoprotein antigen neuraminidase (NA) is a crucial viral enzyme with many potential medical applications; therefore, the development of efficient upstream and downstream processing strategy for the expression and purification of NA is of high importance. In the present work the NA gene from the H1N1 influenza virus strain A/Beijing/262/95 was cloned from viral RNA and expressed in expresSF+ insect cells using the baculovirus expression vector system (BVES). A limited affinity-ligand library was synthesized and evaluated for its ability to bind and purify the recombinant H1N1 neuraminidase. Affinity-ligand design was based on mimicking the interactions of the lock-and-key (LAK) motif (Phe-Gly-Gln), a common structural moiety found in the subunit interface of glutathione S-transferase I (GST I), and plays an important structural role in subunit-subunit recognition. Solid-phase combinatorial chemistry was used to synthesize 13 variants of the lock-and-key lead ligand (Phe-Trz-X, where X was selected alpha-amino acid) using the 1,3,5-triazine moiety (Trz) as the scaffold for assembly. One immobilized ligand, bearing phenylalanine and isoleucine linked on the chlorotriazine ring (Phe-Trz-Ile), displayed high affinity for NA. Absorption equilibrium and molecular modeling studies were carried out to provide a detailed picture of Phe-Trz-Ile interaction with NA. This LAK-mimetic affinity adsorbent was exploited in the development of a facile purification protocol for NA, which led to 335-fold purification in a single-step. The present purification procedure is the most efficient reported so far for recombinant NA. 相似文献