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61.
62.
Celal Tuğrul Zeyrek Nefise Dilek Mustafa Yıldız Hüseyin Ünver 《Molecular physics》2014,112(19):2557-2574
Synthesis, crystallographic characterisation, spectroscopic (Fourier transform infrared spectroscopy [FT-IR]) and density functional modelling studies of the Schiff base 1-[(4-ethoxyphenylimino)methyl]napthalene-2-ol (C19H17NO2) have been reported. The molecular structure obtained from X-ray single-crystal analysis of the investigated compound in the ground state has been compared using Hartree–Fock and density functional theory (DFT) with the 6-311++G(d,p) basis set. In addition to the optimised geometrical structures, atomic charges, molecular electrostatic potential, natural bond orbital, non-linear optical (NLO) effects and thermodynamic properties of the compound have been investigated by using DFT. The experimental (FT-IR) and calculated vibrational frequencies (using DFT) of the title compound have been compared. The solvent effect was also investigated for obtained molecular energies and the atomic charge distributions of the compound. There exists a good correlation between experimental and theoretical data for enol-imine form of the compound. The total molecular dipole moment (µ), linear polarisability (α), and the first-order hyperpolarisability (β) were predicted by the B3LYP method with different basis sets 6-31G(d), 6-31+G(d,p), 6-31++G(d,p), 6-311+G(d) 150 and 6-311++G(d,p) for investigating the effects of basis sets on the NLO properties. Our computational results yield that βtot for the title compound is greater than those of urea. 相似文献
63.
Huseyin Bekir Yildiz Dilek Odaci Demirkol Serkan Sayin Mustafa Yilmaz Ozcan Koysuren Musa Kamaci 《高分子科学杂志,A辑:纯化学与应用化学》2013,50(10):1075-1084
Accumulation of cholesterol in human blood can cause several health problems such as heart disease, coronary artery disease, arteriosclerosis, hypertension, cerebral thrombosis, etc. Therefore, simple and fast cholesterol determination in blood is clinically important. In this study, two types of amperometric cholesterol biosensors were designed by physically entrapping cholesterol oxidase in conducting polymers; thiophene capped poly(ethyleneoxide)/polypyrrole (PEO-co-PPy) and 3-methylthienyl methacrylate-co-p-vinyl benzyloxy poly(ethyleneoxide)/polypyrrole (CP-co-PPy). PEO-co-PPy and CP-co-PPy were synthesized electrochemically and cholesterol oxidase was immobilized by entrapment during electropolymerization. The amperometric responses of the enzyme electrodes were measured by monitoring oxidation current of H2O2 at +0.7 V in the absence of a mediator. Kinetic parameters, such as Km and Imax, operational and storage stabilities, effects of pH and temperature were determined for both entrapment supports. Km values were found as 1.47 and 5.16 mM for PEO-co-PPy and CP-co-PPy enzyme electrodes, respectively. By using these Km values, it can be observed that ChOx immobilized in PEO-co-PPy shows higher affinity towards the substrate. 相似文献
64.
A mild and practically convenient one-pot procedure for the Mannich reaction via condensation of amines, aldehydes and malonates, β-ketoesters, or β-dicarbonyl compounds has been carried out without using any organic solvent, metallic catalyst, or Lewis acids or bases at room temperature. The present protocol offers several advantages, such as goods yields, simple procedure with easy workup, and the absence of any volatile, hazardous organic solvents and metallic catalyst. 相似文献
65.
Water was a suitable medium for Paal–Knorr pyrrole cyclocondensation. Hexa-2,5-dione was reacted with several aliphatic and aromatic primary amines, affording N-substituted 2,5-dimethyl pyrrole derivatives in good to excellent yields. An efficient, green method using water either as environmentally friendly solvent or catalyst was presented. 相似文献
66.
Yonca Duman Dilek Kazan Aziz Ak?n Denizci Altan Erarslan 《Applied biochemistry and biotechnology》2014,172(1):469-486
In this study, our investigations showed that the increasing concentrations of all examined mono alcohols caused a decrease in the V m, k cat and k cat/K m values of Bacillus clausii GMBE 42 serine alkaline protease for casein hydrolysis. However, the K m value of the enzyme remained almost the same, which was an indicator of non-competitive inhibition. Whereas inhibition by methanol was partial non-competitive, inhibition by the rest of the alcohols tested was simple non-competitive. The inhibition constants (K I) were in the range of 1.32–3.10 M, and the order of the inhibitory effect was 1-propanol>2-propanol>methanol>ethanol. The ΔG ≠ and ΔG ≠ E???T values of the enzyme increased at increasing concentrations of all alcohols examined, but the ΔG ≠ ES value of the enzyme remained almost the same. The constant K m and ΔG ≠ ES values in the presence and absence of mono alcohols indicated the existence of different binding sites for mono alcohols and casein on enzyme the molecule. The k cat of the enzyme decreased linearly by increasing log P and decreasing dielectric constant (D) values, but the ΔG ≠ and ΔG ≠ E???T values of the enzyme increased by increasing log P and decreasing D values of the reaction medium containing mono alcohols. 相似文献
67.
Dilek Kul 《Journal of Analytical Chemistry》2014,69(10):970-981
Tolterodine tartrate, a muscarinic receptor antagonist, was oxidized in various buffer media with different pH values using cyclic, differential pulse, and square wave voltammetric techniques on glassy carbon and boron-doped diamond electrodes. Two irreversible anodic peaks were obtained. The oxidation process of tolterodine tartrate was diffusion controlled depending on pH for both electrodes. A detailed oxidation mechanism was proposed and discussed. The dependences of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were investigated. A linear response between the peak current and the tolterodine tartrate concentration was obtained using differential pulse and square wave voltammetric techniques in the range of 0.4–8.0 μM for the peak at lower potential in acetate buffer at pH 5.7 and 0.4–40.0 μM for the peak at higher potential in 0.1 M H2SO4 on glassy carbon electrode and in the range of 0.4–40.0 μM in Britton-Robinson buffer at pH 11.0 on boron-doped diamond electrode. Limit of detection values varied between 0.04 and 0.13 μM for both techniques and electrodes. The repeatability, reproducibility, precision, and accuracy of the proposed methods were investigated. The recovery studies were also achieved to check selectivity, precision, and accuracy of the methods. The proposed methods were successfully applied to determine tolterodine tartrate from pharmaceutical dosage forms without any interference from inactive excipients. 相似文献
68.
This work describes a new, simple, and sensitive colorimetric determination method for indoxyl sulfate (indican) by fiber optic UV-Vis spectrophotometry coupled to cloud point extraction as the separation-preconcentration method. This method is based on the diazotization of sulphanilic acid in acidic medium followed by its coupling with indoxyl sulfate (indican), which gives an azo product and extraction of the colored product using the cloud point extraction (CPE) technique. The optimal extraction and reaction conditions (e.g., acid and reagent concentrations, effect of time) were studied, and the analytical characteristics of the method (e.g., limit of detection, linear range, preconcentration factor) were obtained. Linear response was achieved within 0.9–44 μg/mL and the detection limit was estimated as 0.6 μg/mL. The inter-day and intraday relative standard deviations were in the ranges 1.2–1.3% and 1.6–1.8% for indican. The method was applied to the determination of indican in human spiked urine samples; Recoveries within 96–99% were obtained. 相似文献
69.
70.
Chitosan membrane with glutathione reductase and sulfhydryl oxidase (SOX) was subsequently integrated onto the surface of spectrographic graphite rods for obtaining a glutathione biosensor. The working principle was based on the monitoring of O2 consumption that correlates the concentration of glutathione during the enzymatic reaction. A linear relationship between sensor response and concentration was obtained between 0.5 and 2.0 mM for oxidized glutathione (GSSG), and 0.2–1.0 mM for reduced glutathione (GSH) in the presence of 2 μM nicotinamide adenine dinucleotide phosphate (NADPH) under the optimum working conditions. Also, reduced/oxidized glutathione were separated by HPLC and utility of bienzymatic system was investigated as an electrochemical detector for the analysis of these compounds. All data were given as a comparison of two systems: biosensor and diode array detector (DAD). 相似文献