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61.
Chemical bonding configuration of the adsorbed oxygen on diamond polycrystalline hydrogenated surface was investigated by high resolution electron energy loss spectroscopy (HR-EELS). Hot filament chemical vapor deposited diamond films with sub-micron grain size have been exposed in-situ to thermally activated atomic oxygen (AO) and annealed in ultra-high vacuum in the range of 600–900 °C. HR-EELS features comparison of as-deposited and AO exposed diamond surface as a function of thermal annealing suggests that AO preferentially adsorbs on hydrogenated (111) facets keeping hydrogenated (100) ones intact. 相似文献
62.
Classical (Heisenberg) simulations show that the total magnetization of the lowest-energy states of clusters made of antiferromagnetically
coupled chromium atoms is planar, rather than collinear, depending on the arrangement of the atoms. Although the model Hamiltonian
is not restrictive, many cluster configurations of various numbers of atoms do not use all three directions for the spins.
This result confirms the conclusion drawn from the local-spin DFT calculation by Kohl and Bertsch that clusters of N≤13 have non-collinear magnetic moments. The present simulations show non-collinear spin ordering also for bigger clusters,
designed to be as spherical as possible following the bcc arrangement, when atoms interact both with the nearest and next-nearest neighbours. Depending on the signs of the coupling
constants frustration appears. The advantage of the discrete model, despite the simplicity, is that very large clusters and
magnetization at finite temperatures can be studied. This model predicts that clusters with specific numbers of atoms interacting
only with the nearest neighbours have collinear spins as in the bulk. We also apply the model to simulate the destruction
of the anti-ferromagnetic ordering by thermal fluctuations. This model shows no unique magnetization of mixed Fe
0.33
Cr
0.67, which is consistent with experimental observations. 相似文献
63.
64.
Koller FO Schreier WJ Schrader TE Malkmus S Schulz C Dietrich S Rück-Braun K Braun M 《The journal of physical chemistry. A》2008,112(2):210-214
The ring-opening and ring-closure reactions of a photochromic indolylfulgimide are investigated with femtosecond vibrational spectroscopy. Spectral signatures due to excited-state decay and vibrational cooling are seen in the mid-IR region. For the ring-opening reaction triggered with visible pulses, a lifetime of the excited electronic state of 4 ps was obtained in polar solution. In a nonpolar solvent, this time constant is reduced to 2 ps. The ring-closure reaction induced with UV pulses displays an excited-state lifetime and thus a building of the photoproduct of roughly 0.5 ps. For all processes, the subsequent cooling occurs on a 15-ps time scale lasting up to approximately 50 ps. The time-resolved IR measurements do not support the existence of any long-living intermediate states. 相似文献
65.
Burck S Gudat D Nieger M Du Mont WW 《Journal of the American Chemical Society》2006,128(12):3946-3955
P-Hydrogen-substituted 1,3,2-diazaphospholenes 1 were prepared by an improved procedure from diazadienes and were characterized by spectroscopy and in one case by X-ray diffraction. A unique hydride-type reactivity of the P-H bonds was documented by extensive reactivity studies. Aldehydes and ketones were readily reduced to diazaphospholene derivatives of the corresponding alcohols, with alkyl-substituted ketones being converted at much lower rates than aldehydes or diaryl ketones. Reactions with the tetrachlorides of group 14 elements proceeded via hydride/chloride metathesis to give either partially chlorinated derivatives EH(n)Cl(4-n) (n = 0-3 for E = C, Si) or HCl and phosphenium salts 16c[ECl3] (for E = Ge, Sn) which were characterized by spectroscopic and X-ray diffraction studies. Tin dichloride was readily reduced to the element. Reactions of 1c with the P-chloro-diazaphospholene 3c and the salt 16c[OTf] allowed the first experimental detection of intermolecular exchange of a hydride, rather than a proton, between phosphine derivatives. Computational studies indicated that the hydride transfer between 1c and the cation 16c involves a transient H-bridged species with bonding properties similar to those of B2H7-. The preference for the formation of these bridged intermediates over P-P bonded phosphenium-phosphine adducts is attributed to the low electrophilicity of the diazaphospholenium cations and characterizes a novel reaction mode for phosphenium ions. 相似文献
66.
Soriaga RA Nguyen JM Albright TA Hoffman DM 《Journal of the American Chemical Society》2010,132(51):18014-18016
The addition of 4 equiv of LiN=C-t-Bu(2) to CrCl(3), MoCl(5), and WCl(6) in diethyl ether produced the complexes M(N=C-t-Bu(2))(4) (M = Cr, Mo, W). Single-crystal X-ray diffraction studies revealed that the molecules have flattened tetrahedral geometries with virtual D(2d) symmetry in the solid state. (1)H and (13)C NMR spectra indicated that the complexes are diamagnetic, and a qualitative MO analysis showed that the orthogonal π-donor and -acceptor orbitals of the ketimide ligand cooperatively split the d(xy) and d(z2) orbitals sufficiently to allow spin pairing in the d(xy) orbital. A more sophisticated quantum-mechanical analysis of Cr(N=C-t-Bu(2))(4) using density functional/molecular mechanics methods confirmed the qualitative analysis by showing that the singlet state is 27 kcal/mol more stable than the triplet state. 相似文献
67.
We study the phase behavior of colloidal suspensions the solvents of which are considered to be binary liquid mixtures undergoing phase segregation. We focus on the thermodynamic region close to the critical point of the accompanying miscibility gap. There, due to the colloidal particles acting as cavities in the critical medium, the spatial confinements of the critical fluctuations of the corresponding order parameter result in the effective, so-called critical Casimir forces between the colloids. Employing an approach in terms of effective, one-component colloidal systems, we explore the possibility of phase coexistence between two phases of colloidal suspensions, one being rich and the other being poor in colloidal particles. The reliability of this effective approach is discussed. 相似文献
68.
Silvia Anthoine Dietrich Renate Lindauer Claire Stierlin Jürg Gertsch Dr. Ruth Matesanz Dr. Sara Notararigo José Fernando Díaz Dr. Karl‐Heinz Altmann Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(39):10144-10157
A series of epothilone B and D analogues bearing isomeric quinoline or functionalized benzimidazole side chains has been prepared by chemical synthesis in a highly convergent manner. All analogues have been found to interact with the tubulin/microtubule system and to inhibit human cancer cell proliferation in vitro, albeit with different potencies (IC50 values between 1 and 150 nM ). The affinity of quinoline‐based epothilone B and D analogues for stabilized microtubules clearly depends on the position of the N‐atom in the quinoline system, while the induction of tubulin polymerization in vitro appears to be less sensitive to N‐positioning. The potent inhibition of human cancer cell growth by epothilone analogues bearing functionalized benzimidazole side chains suggests that these systems might be conjugated with tumor‐targeting moieties to form tumor‐targeted prodrugs. 相似文献
69.
David Gode Christian Schmitt Matthias Engel Dietrich A. Volmer 《Analytical and bioanalytical chemistry》2014,406(12):2841-2852
Enzyme-catalyzed reactions play key roles in disease pathology, thus making them relevant subjects of therapeutic inhibitor screening experiments. Matrix-assisted laser desorption/ionization (MALDI) assays have been demonstrated to be able to replace established screening approaches. They offer increased sample throughput, but care must be taken to avoid instrumental bias from differences in ionization efficiencies. We compared a MALDI-triple-quadrupole (QqQ) method for the Dyrk1A peptide substrate woodtide to LC–MS, liquid chromatography with ultraviolet detection (LC–UV), luminescence, and radiometric assays. MALDI measurements were performed on a MALDI-QqQ instrument in the multiple-reaction monitoring mode. Different MALDI conditions were investigated to address whether matrix type, sample support, and MRM- or SIM-based detection conditions can be used to accommodate the molar responses of substrate peptide and its phosphorylated form. UV detection served as a reference method. The impact of MALDI matrix on IC50 values was small, even considering that matrix preparations were used that are known to alleviate response differences. IC50 values determined by MALDI were ca. 2-fold lower than those determined by LC–UV. Although MALDI generated lower ion yields for the phosphorylated peptide than for the peptide substrate, we found that a correction of compound potencies was readily possible using correction factors based on unbiased LC–UV results. A thorough method development delivered a robust assay with excellent performance (Z′ > 0.91) that was close to that seen for LC–UV. Figure
? 相似文献
70.
Dörr FA Kovačevi B Maksi ZB Pinto E Volmer DA 《Journal of the American Society for Mass Spectrometry》2011,22(11):2011-2020
The aim of this study was to investigate the unusual gas-phase dissociation behavior of two epimer pairs of protonated gonyautoxins
(GTX) following electrospray ionization in comparison to their deprotonated counterparts. The chemical structures of the investigated
GTX1-4 variants vary in their substitution pattern at N-1 and the stereochemical orientation of the hydroxysulfate group at C-11
(11α for GTX1/2 versus 11β for GTX3/4). The direct comparison of mass spectra in positive and negative ion modes illustrated two distinct features: first, an intriguing
difference between protonated 11α and 11β species, where 11α conformations exhibited almost complete dissociation of [M +
H]+ ions via facile SO3 elimination, while 11β species remained mostly intact as [M + H]+; and second, the lack of such differences for the deprotonated counterparts. In this study, we propose an acid-catalyzed
elimination mechanism from density functional theory calculations, initiated by a proton transfer of a guanidinium proton
to the hydroxysulfate group with simultaneous SO3 release, which is only possible for the 11α conformation based on intramolecular distances. The same mechanism explains the
lack of a comparable SO3 loss in the negative ion mode. CID experiments supported this proposed mechanism for GTX1 and GTX2. Computational modeling of product ions seen in the CID spectra of GTX3 and GTX4 established that the lowest energy dissociation pathway for the 11β epimers is elimination of water with the possibility
for further SO3 release from the intermediate product. Experimental data for structurally analogous decarbamoyl gonyautoxins confirmed the
evidence for the GTX compounds as well as the proposed elimination mechanisms. 相似文献