Peptide-mediated blood-brain barrier transport of polymersomes

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in?vitro model and in?vivo. The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented.     

Thermomolecular orientation of nonpolar fluids

We investigate the response of molecular fluids to temperature gradients. Using nonequilibrium molecular dynamics computer simulations we show that nonpolar diatomic fluids adopt a preferred orientation as a response to a temperature gradient. We find that the magnitude of this thermomolecular orientation effect is proportional to the strength of the temperature gradient and the degree of molecular anisotropy, as defined by the different size or mass of the molecular atomic sites. We show that the preferred orientation of the molecules follows the same trends observed in the Soret effect of binary mixtures. We argue this is a general effect that should be observed in a wide range of length scales.     

High-resolution investigation of the excited electronic states of CaSH and SrSH by laser excitation spectroscopy – ARTICLE WITHDRAWN

WITHDRAWN TO APPEAR IN SPECIAL ISSUE IN 2007     

Ranking and unranking planar embeddings

In this paper, we give a formula for computing the number of different planat embeddings of any planar biconnected graph. The enumeration method used in deriving the formula readily gives rise to efficient algorithms for the ranking, unranking and random generation of embeddings of the given graph. We also give linear time algorithms for checking planarity and constructing any particular embedding.     

A flux-vector splitting method for steady Navier-Stokes equations

The flux-vector splitting method is applied to the convective part of the steady Navier-Stokes equations for incompressible flow. By the use of partial upwind differences in the split first-order part and central differences in the second-order part, a set of discrete equations is obtained which can be solved by vector variants of classical relaxation schemes. It is shown that accurate results can be obtained on one of the GAMM backward-facing step test problems.     

PHOTOCHEMICAL DAMAGE TO DNA TREATED WITH CHLORPROMAZINE AND NEAR UV RADIATION UNDER AEROBIC AND ANAEROBIC CONDITIONS

Double stranded salmon sperm DNA in a chlorpromazine (CPZ) solution is damaged when irradiated with near UV light. The damage of irradiated DNA can be estimated by measuring the increase in extinction at 260 nm following incubation at 60°C of the DNA with formaldehyde. Moreover, DNA irradiated in the presence of CPZ or kept in the dark separate quite differently in an aqueous polymer two-phase system. DNA irradiated in the presence of CPZ seemed to be susceptible to digestion by endonuclease S1, while the endonuclease of Neurospora crassa could not digest this DNA. Irradiation under aerobic conditions seemed to be less disastrous for DNA than under anaerobic conditions.     

Wärmeeffekte bei Deformation

Zusammenfassung Aus kalorimetrischen Messungen bei stufenweiser Deformation von Weichkautschukproben und gleichzeitiger Kenntnis der mechanischen Arbeit pro Stufe folgt, daß die von der kinetisch-statistischen Theorie vorausgesetzte Bedingung, die Innere Energie hänge nicht von der Dehnung ab, eine Idealisierung darstellt, die man im tatsächlichen Verhalten selbst bei von der Theorie als geeignet angesehenen Fällen selten oder vielleicht überhaupt nicht verifiziert findet.