Copper(I) complexes of pentatomic heterocyclic selone donors

Summary New complexes of copper(I) with some heterocyclic pentatomic rings, X·CH₂·CH₂·NR·CSe, where X=CH₂, NH, NMe, NEt, S and R=H, Me, Et, were prepared by reacting copper(II) chloride and bromide in MeOH. The stoichiometry of the complexes and the binding mode of the ligands have been discussed comparatively, together with those of the thione parents. It is noteworthy that the selone ligands with R=H (L) yield complexes of the type CuL_nY, (n=1,2 or 3; Y=Cl or Br) like the corresponding thione ones. On the contrary, when R=Me or Et, the selonic ligands (L) give complexes whose stoichiometries, Cu₂LY₂ and Cu₃L₂Y₃, differ from the thione homologues. The i.r. spectra of the complexes compared with those of the ligands support the coordinative bondvia selenium atom.     

Characterization and biological properties of a copper(II) complex with pyruvic acid thiosemicarbazone

Summary A copper(II) complex with pyruvic acid thiosemicarbazone (PTSC) of composition Cu(PTSC) (PTSC-H)Cl was characterized by IR, UV/Vis, and EPR spectroscopy. The antifungo, herbicide, cytotoxic and antitumor activities of the complex andPTSC are reported.

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Charakterisierung und biologische Eigenschaften eines Kupfer(II)-Komplexes mit Brenztraubensäurethiosemicarbazon

Zusammenfassung Ein Kupfer(II)-Komplex mit Brenztraubensäurethiosemicarbazon (PTSC) der Zusammensetzung Cu(PTSC)(PTSC-H)Cl wurde mittels IR-, UV/Vis- und EPR-Spektroskopie charakterisiert. Es wird über die antifungalen, herbiziden, cytotoxischen und antitumoralen Aktivitäten des Komplexes und vonPTSC berichtet.

     

Select estrogens within the complex formulation of conjugated equine estrogens (Premarin?) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease

Background  

Results of the Women's Health Initiative Memory Study (WHIMS) raised concerns regarding the timing and formulation of hormone interventions. Conjugated equine estrogens (CEE), used as the estrogen therapy in the WHIMS trial, is a complex formulation containing multiple estrogens, including several not secreted by human ovaries, as well as other biologically active steroids. Although the full spectrum of estrogenic components present in CEE has not yet been resolved, 10 estrogens have been identified. In the present study, we sought to determine which estrogenic components, at concentrations commensurate with their plasma levels achieved following a single oral dose of 0.625 mg CEE (the dose used in the WHIMS trial) in women, are neuroprotective and whether combinations of those neuroprotective estrogens provide added benefit. Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER).     

Using Process Control Chart Techniques to Analyse Crime Rates in Houston,Texas

In this paper we use ARIMA time series models and statistical process control techniques to determine if changes occurred in the process that generated a series of observations. The procedure is applied to eight crime time series for the city of Houston, Texas: total crime, murder, rape, robbery, aggravated assault, burglary, theft, and motor vehicle theft. The objective of our analysis is to determine if, after the institution of an overtime programme by the Houston Police Department, the different series show some statistical evidence of a change. Our results show that the categories of total crime, robbery, burglary, theft, and motor vehicle theft decreased significantly. Murder and rape remained statistically unchanged, while aggravated assault continued to increase.     

Bulk modulus for some simple molecular fluids

The bulk modulus B of several molecular fluids composed of rigid molecules has been calculated from p-p-T data obtained with a high-pressure vibrating tube densitometer. The data of all the substances studied, including Ar, can be described by a single master curve when plotted versus the reduced density *, in agreement with the predictions of the Gubbins-Gray perturbation theory for fluids with the same reference system. Combination of p-p-T and C_v data with the virial theorem has allowed the calculation of the exponent characterizing the repulsive branch of the intermolecular potential n. The different values of n suggest that different reference systems should be used for each substance, in contradiction with the conclusions obtained from the B versus * curves. This indicates that p-p-T data are less sensitive to the details of the intermolecular potential than their combination with other thermal properties like C_v, internal energy or residual entropy.     

Complexes of Cu(II) and Co(II) with NN′-bis-8-quinolylethylenediamine

This article describes some complexes of Cu(II) and Co(II with NN′-bis-8-quinolylethylenediamine ligand (nn′). All the compounds are of stoichiometry [MX₂(nn′)] (M = Cu or Co; X = Cl^?, Br^?, I^?, NO^?₃ or SCN^?). The electronic spectra are consistent with distorted octahedral geometry around the ions, indicating the four coordination of the nn′ ligand. Magnetic susceptibility measurements down to 100 K show antiferromagnetic interactions in all the Cu(II) compounds demonstrating the existence of the ionic and bridging X group. Infrared spectra show the presence of ionic and bridging nitrate in the [M(NO₃)₂(nn′)] (M = Co or Cu) compounds and ionic and bridging NCS group in the [Cu(NCS)₂(nn′)] compound.     

Sur le choix du paramètre d'ajustement dans le lissage par fonctions spline

Summary We consider the problem of approximating an unknown functionf, known with error atn equally spaced points of the real interval [a, b].To solve this problem, we use the natural polynomial smoothing splines. We show that the eigenvalues associated to these splines converge to the eigenvalues of a differential operator and we use this fact to obtain an algorithm, based on the Generalized Cross Validation method, to calculate the smoothing parameter.With this algorithm, we divide byn the time used by classical methods.