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441.
Learning and memory depend on molecular mechanisms involving the protein machinery. Recent evidence proposes that post-translational modifications (PTMs) play a major role in these cognitive processes. PTMs including phosphorylation of serine, threonine, and tyrosine are already well-documented to play a role for synaptic plasticity of the brain, neurotransmitter release, vesicle trafficking and synaptosomal or synaptosomal-associated proteins are substrates of a series of specific protein kinases and their counterparts, protein phosphatases. But protein phosphorylation is only one out of many possible PTMs and first work shows a role of palmitoylation as well as glycosylation for proteins involved in memory formation. Recent technology may now allow reliable detection and even quantification of PTMs of proteins involved in the cognitive system. This will contribute to the understanding of mechanisms for learning and memory formation at the chemical level and has to complement determination of protein levels and indeed determination of protein expression per se generates limited information. The many other PTMs expected including protein nitrosylation and alkylation will even represent targets for pharmacological interventions but in turn increase the complexity of the system. Nevertheless, determination of the presence and the function of PTMs is mandatory and promising cognitive research at the protein chemical level. 相似文献
442.
Diao Y Whaley KE Helgeson ME Woldeyes MA Doyle PS Myerson AS Hatton TA Trout BL 《Journal of the American Chemical Society》2012,134(1):673-684
Although nanoporous materials have been explored for controlling crystallization of polymorphs in recent years, polymorphism in confined environments is still poorly understood, particularly from a kinetic perspective, and the role of the local structure of the substrate has largely been neglected. Herein, we report the use of a novel material, polymer microgels with tunable microstructure, for controlling polymorph crystallization from solution and for investigating systematically the effects of nanoconfinement and interfacial interactions on polymorphic outcomes. We show that the polymer microgels can improve polymorph selectivity significantly. The polymorphic outcomes correlate strongly with the gel-induced nucleation kinetics and are very sensitive to both the polymer microstructure and the chemical composition. Further mechanistic investigations suggest that the nucleation-templating effect and the spatial confinement imposed by the polymer network may be central to achieving polymorph selectivity. We demonstrate polymer microgels as promising materials for controlling crystal polymorphism. Moreover, our results help advance the fundamental understanding of polymorph crystallization at complex interfaces, particularly in confined environments. 相似文献
443.
Our dynamic laser light scattering(LLS) study shows that the current widely used protocols of dissolving amyloidogenic protein/peptide do not really result in a true solution;namely,there always exist a trace amount of interchain aggregates,which greatly affect the association kinetics,partially explaining why different kinetics were reported even for a solution with identical protein and solvent.Recently,using a combination of the conventional dissolution procedure and our newly developed ultra-filtration method,we have developed a novel protocol to prepare a true solution of amyloidogenic protein/peptide without any interchain aggregates.The resultant solutions remain in their monomeric state for at least one week,which is vitally important for further study of the very initial stage of the interchain association under the physiological conditions because more and more evidence suggests that it is those small oligomers rather than large fabric aggregates that are cytotoxic.In addition,this study shows that combining static and dynamic LLS can lead to more physical and microscopic information about the protein association instead of only the size distribution. 相似文献
444.
Ablikim M Bai JZ Ban Y Bian JG Cai X Chen HF Chen HS Chen HX Chen JC Chen J Chen YB Chi SP Chu YP Cui XZ Dai YS Diao LY Deng ZY Dong QF Du SX Fang J Fang SS Fu CD Gao CS Gao YN Gu SD Gu YT Guo YN Guo YQ Guo ZJ Harris FA He KL He M Heng YK Hu HM Hu T Huang GS Huang XT Ji XB Jiang XS Jiang XY Jiao JB Jin DP Jin S Jin Y Lai YF Li G Li HB Li HH Li J Li RY Li SM Li WD Li WG Li XL Li XN Li XQ Li YL Liang YF Liao HB Liu BJ Liu CX Liu F Liu F Liu HH Liu HM Liu J Liu JB Liu JP Liu Q Liu RG Liu ZA Lou YC 《Physical review letters》2006,96(16):162002
An enhancement near threshold is observed in the omega(phi) invariant mass spectrum from the doubly Okubo-Zweig-Iizuka-suppressed decays of J/psi-->gamma(omega)phi, based on a sample of 5.8 x 10(7) J/psi events collected with the BESII detector. A partial wave analysis shows that this enhancement favors JP=0+, and its mass and width are M=1812(+19)(-26)(stat)+/-18(syst) MeV/c2 and Gamma=105+/-20(stat)+/-28(syst) MeV/c2. The product branching fraction is determined to be B(J/psi-->gammaX)B(X-->omega(phi))=[2.61+/-0.27(stat)+/-0.65(syst)]x10(-4). 相似文献
445.
Microstructure and rheological properties of liquid crystallines formed in Brij 97/water/IPM system 总被引:1,自引:0,他引:1
The phase diagram of Brij 97/water/IPM systems was determined at 25 degrees C. Rich liquid crystalline phases including Lalpha, H1, and cubic Fd3m phases were identified by means of small angle X-ray scattering (SAXS). Microstructure transitions of liquid crystals with changes in surfactant concentration and oil content are explained qualitatively by the surfactant packing parameter (vL/aSlc). Dynamic rheological results indicate that all three kinds of liquid crystals investigated show high elasticity. The lamellar, Lalpha, phases formed in Brij 97/water with two different oils, oleic acid and geraniol, were also studied in comparison with those of Brij 97/water/IPM systems. The strength of the network of lamellar phases formed in Brij 97/water/oleic acid and Brij 97/water/geraniol systems are appreciably stronger than for Brij 97/water/IPM systems, indicated by the smaller area of surfactant molecules at the interface and the higher moduli (G' and G'). 相似文献
446.
Fan Z Diao CH Song HB Jing ZL Yu M Chen X Guo MJ 《The Journal of organic chemistry》2006,71(3):1244-1246
An inclusion complex formed by beta-cyclodextrin and quinine has been investigated in solution and in the solid state, in which the quinoline ring and the aliphatic ring locate in different hydrophobic cavities, respectively. The study on the inclusion geometry and weak interactions shows that the difference in conformation for this complex is a result of three main packing arrangement considerations, which can provide an ideal model mimicking enzyme-substrate interactions. 相似文献
447.
Huaian Diao 《Numerical Linear Algebra with Applications》2009,16(2):87-107
We give explicit expressions for the componentwise condition number for eigenvalue problems with structured matrices. We will consider only linear structures and show a general result from which expressions for the condition numbers follow. We obtain explicit expressions for the following structures: Toeplitz and Hankel. Details for other linear structures should follow in a straightforward manner from our general result. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
448.
In this paper, we prove that the Jones polynomial of a link diagram obtained through repeated tangle replacement operations can be computed by a sequence of suitable variable substitutions in simpler polynomials. For the case that all the tangles involved in the construction of the link diagram have at most k crossings (where k is a constant independent of the total number n of crossings in the link diagram), we show that the computation time needed to calculate the Jones polynomial of the link diagram is bounded above by O(nk). In particular, we show that the Jones polynomial of any Conway algebraic link diagram with n crossings can be computed in O(n2) time. A consequence of this result is that the Jones polynomial of any Montesinos link and two bridge knot or link of n crossings can be computed in O(n2) time. 相似文献
449.
MRA wavelets have been widely studied in recent years due to their applications in signal processing. In order to understand the properties of the various MRA wavelets, it makes sense to study the topological structure of the set of all MRA wavelets. In fact, it has been shown that the set of all MRA wavelets (in any given dimension with a fixed expansive dilation matrix) is path-connected. The current paper concerns a class of functions more general than the MRA wavelets, namely normalized tight frame wavelets with a frame MRA structure. More specifically, it focuses on the parallel question on the topology of the set of all such functions (in the given dimension with a fixed dilation matrix): is this set path-connected? While we are unable to settle this general path-connectivity problem for the set of all frame MRA normalized tight frame wavelets, we show that this holds for a subset of it. An s-elementary frame MRA normalized tight frame wavelets (associated with a given expansive matrix A as its dilation matrix) is a normalized tight frame wavelet whose Fourier transform is of the form $\frac{1}{\sqrt{2\pi}}\chi_{E}$ for some measurable set E?? d . In this paper, we show that for any given d×d expansive matrix A, the set of all (A-dilation) s-elementary normalized tight frame wavelets with a frame MRA structure is also path-connected. 相似文献
450.