Phototriggered Release of a Transmembrane Chloride Carrier from an o‐Nitrobenzyl‐Linked Procarrier

While there have been many studies on synthetic chloride carriers and a recent application for apoptotic cell death, so far, the proposed huge potential of these systems in targeting cancer has not been realized due to their cytotoxicity to healthy cells. Herein, we describe the development of an indole‐2‐carboxamide receptor as an efficient membrane chloride carrier while the corresponding o‐nitrobenzyl‐linked derivative is a procarrier of the ion. Photoirradiation of the procarrier in liposomes results in release of the active carrier with up to 90 % transport efficiency. Such photorelease of the carrier also works within cancer cells, resulting in efficient cell killing. Such photocleavable procarriers have great potential as a photodynamic therapy to combat various types of cancers.     

Water-soluble polymer anchored peroxotitanates as environmentally clean and recyclable catalysts for mild and selective oxidation of sulfides with H2O2 in water

Anchoring of peroxotitanium (pTi) species to linear water-soluble acrylic acid based polymers, poly(sodium acrylate) (PA) and poly(sodium methacrylate) (PMA) led to the successful synthesis of a pair of new, water-tolerant and recyclable catalysts of the type [Ti₂(O₂)₂O₂(OH)₂]^4-—L (L = PA or PMA), highly effective in chemoselective sulfoxidation of organic sulfides with 30% H₂O₂ in aqueous medium at ambient temperature. The catalytic protocol is high yielding (TOF up to 11,280 h^?1), operationally simple as well as environmentally clean and safe, being free from halide, or any other toxic auxiliaries. The catalysts are sufficiently stable to afford easy recyclability for at least 10 consecutive reaction cycles of sulfoxidation with consistent activity selectivity profile. Oxidation of dibenzothiophene (DBT) to respective high purity sulfoxide or sulfone could also be accomplished using the same catalysts by variation of reaction conditions.     

Schiff base supported mononuclear organotin(IV) complexes: Syntheses,structures and fluorescence cell imaging

Three mononuclear organotin(IV) complexes supported by Schiff bases have been synthesized. The complexes [(C₆H₅)₂Sn(L)] ( 1 ), [(t‐Bu)₂Sn(L)] ( 2 ) and [(t‐Bu)₂Sn(L')] ( 3 ) (L, L' = deprotonated Schiff bases) were obtained in good yield by the reaction of Schiff bases H ₂ L or H ₂ L′ with corresponding diorganotin dichlorides respectively. All newly synthesized complexes were characterized by means of FT‐IR spectroscopy, elemental analysis and multinuclear (¹H, ¹³C and ¹¹⁹Sn) NMR spectroscopy. In addition, single crystal X‐ray diffraction analyses were employed to establish the solid state molecular structures of these complexes. The structures of 1 – 3 reveal that all complexes are mononuclear with a five‐coordinated tin(IV) centre in it. The absorption and emission properties of all complexes have been investigated. Moreover, cytotoxicity and fluorescence cell imaging studies of theses complexes have been performed.     

Esterase-Activatable Synthetic M+/Cl− Channel Induces Apoptosis and Disrupts Autophagy in Cancer Cells

The formation of a supramolecular synthetic M⁺/Cl⁻ channel in the membrane phospholipid bilayer has been reported upon activation of a methyl pivalate-linked N¹,N³-dialkyl-2-hydroxyisophthalamide by esterases. The channel formation induces apoptosis in cancer cells via the intrinsic pathway. Interestingly, the supramolecular channel was also shown to disrupt autophagy in cancer cells by causing alkalization of lysosomes – a feature that has been confirmed at the cellular and protein level.     

Shannon entropies and Fisher information of K-shell electrons of neutral atoms

We represent the two K-shell electrons of neutral atoms by Hylleraas-type wave function which fulfils the exact behavior at the electron–electron and electron-nucleus coalescence points and, derive a simple method to construct expressions for single-particle position- and momentum-space charge densities, $\rho (\mathit{r})$ and $\gamma (\mathit{p})$ respectively. We make use of the results for $\rho (\mathit{r})$ and $\gamma (\mathit{p})$ to critically examine the effect of correlation on bare (uncorrelated) values of Shannon information entropies (S) and of Fisher information (F) for the K-shell electrons of atoms from helium to neon. Due to inter-electronic repulsion the values of the uncorrelated Shannon position-space entropies are augmented while those of the momentum-space entropies are reduced. The corresponding Fisher information are found to exhibit opposite behavior in respect of this. Attempts are made to provide some plausible explanation for the observed response of S and F to electronic correlation.     

Half-shellT matrix for Coulomb-modified Graz separable potential

We construct a closed form expression for the off-shell Jost function for scattering by the Coulomb-distorted Graz separable potential and express it in the ‘maximal reduced form’. Our result is particularly suitable for numerical computation. We present a case study in support of this and examine the role of Coulomb interaction in thep — p half-shell scattering in the¹ S ₀ channel.     

Off-shell t-matrix for an exponential potential with non-local core interaction

The wave function approach of Van Leeuwen and Reiner to the t-matrix is generalized to the case of a non-local potential. The transition matrix element for this potential is obtained. The results are used to compute the s-wave part of the t-matrix for a non-local square well potential combined with an outside exponential potential.     

Noether-Symmetry Analysis using Alternative Lagrangian Representations

We have sought to work with an approach to Noether symmetry analysis which uses the properties of infinitesimal point transformations in the space-time (q, t) variable to establish the association between symmetries and conservation laws of a dynamical system. In this approach symmetries are expressed in the form of generators. We have studied the variational or Noether symmetries of two uncoupled Harmonic oscillators and two such oscillators coupled by an interaction. Both these systems can have alternative Lagrangian representations. We have studied in detail how the association between symmetries and conservation laws changes as one alters the analytic or Lagrangian representation. This analysis is carried out with a view to explicitly demonstrate that the correlation between symmetry transformation and corresponding invariant quantity depends crucially on the choice of the analytic representation. PACS 45.20.Jj, 45.20.df, 45.20.dh