Protein Allostery at Atomic Resolution

Protein allostery is a phenomenon involving the long range coupling between two distal sites in a protein. In order to elucidate allostery at atomic resoluion on the ligand-binding WW domain of the enzyme Pin1, multistate structures were calculated from exact nuclear Overhauser effect (eNOE). In its free form, the protein undergoes a microsecond exchange between two states, one of which is predisposed to interact with its parent catalytic domain. In presence of the positive allosteric ligand, the equilibrium between the two states is shifted towards domain–domain interaction, suggesting a population shift model. In contrast, the allostery-suppressing ligand decouples the side-chain arrangement at the inter-domain interface thereby reducing the inter-domain interaction. As such, this mechanism is an example of dynamic allostery. The presented distinct modes of action highlight the power of the interplay between dynamics and function in the biological activity of proteins.     

Quantum Coherences and Classical Inhomogeneities as Equivalent Thermodynamics Resources

Quantum energy coherences represent a thermodynamic resource, which can be exploited to extract energy from a thermal reservoir and deliver that energy as work. We argue that there exists a closely analogous classical thermodynamic resource, namely, energy-shell inhomogeneities in the phase space distribution of a system’s initial state. We compare the amount of work that can be obtained from quantum coherences with the amount that can be obtained from classical inhomogeneities, and find them to be equal in the semiclassical limit. We thus conclude that coherences do not provide a unique thermodynamic advantage of quantum systems over classical systems, in situations where a well-defined semiclassical correspondence exists.     

Transfer measurements for the Ti+Ni systems at near barrier energies

Large enhancements have been observed in the sub-barrier fusion cross sections for Ti+Ni systems in our previous studies. Coupled channel calculations incorporating couplings to 2⁺ and 3⁻ states failed to explain these enhancements completely. A possibilty of transfer channels contributing to the residual enhancements had been suggested. In order to investigate the role of relevant transfer channels, measurements of one- and two-nucleon transfer were carried out for ^46,48Ti+⁶¹Ni systems. The present paper gives the results of these studies.     

Modelling a predator–prey system with infected prey in polluted environment

A predator–prey model with logistic growth in prey is modified by introducing an SIS parasite infection in the prey. We have studied the combined effect of environmental toxicant and disease on prey–predator system. It is assumed in this paper that the environmental toxicant affects both prey and predator population and the infected prey is assumed to be more vulnerable to the toxicant and predation compared to the sound prey individuals. Thresholds are identified which determine when system persists and disease remains endemic.     

A non-contact technique for evaluation of elastic structures at large stand-off distances: applications to classification of fluids in steel vessels

A novel technique for non-contact evaluation of structures in air at large stand-off distances (on the order of several meters) has been developed. It utilizes a recently constructed air-coupled, parametric acoustic array to excite the resonance vibrations of elastic, fluid-filled vessels. The parametric array is advantageous for NDE applications in that it is capable of producing a much narrower beamwidth and broader bandwidth than typical devices that operate under linear acoustic principles. In the present experiments, the array operates at a carrier frequency of 217 kHz, and the sound field several meters from the source is described spectrally by the envelope of the drive voltage. An operating bandwidth of more than 25 kHz at a center frequency of 15 kHz is demonstrated. For the present application, the array is used to excite vibrations of fluid-filled, steel containers at stand-off distances of greater than 3 m. The vibratory response of a container is detected with a laser vibrometer in a monostatic configuration with the acoustic source. By analyzing the change in the response of the lowest order, antisymmetric Lamb wave as the interior fluid loading conditions of the container are changed, the fluid contained within the steel vessel is classified.     

Estimating the spectral measure of an extreme value distribution

Let (X₁, Y₁), (X₂, Y₂),…, (X_n, Y_n) be a random sample from a bivariate distribution function F which is in the domain of attraction of a bivariate extreme value distribution function G. This G is characterized by the extreme value indices and its spectral measure or angular measure. The extreme value indices determine both the marginals and the spectral measure determines the dependence structure. In this paper, we construct an empirical measure, based on the sample, which is a consistent estimator of the spectral measure. We also show for positive extreme value indices the asymptotic normality of the estimator under a suitable 2nd order strengthening of the bivariate domain of attraction condition.     

The superfluid vacuum state,time-varying cosmological constant,and nonsingular cosmological models

Some cosmological consequences of the superfluid vacuum state developed previously by the authors are discussed, particularly with regard to the initial stages of the universe. The transition temperature of the hadronic superfluid (superfluid during the hadron era) is estimated to be 10 ¹³ K, which is the same as the Hagedorn temperature, giving a physical basis of the thermodynamic bootstrap model.     

Ballistic transmission through quasi-periodic shape barrier resonant tunneling structures

A theoretical model is proposed to study the ballistic electron transport for a quasi-periodic multibarrier structure where two different barrier shapes are arranged according to the Thue–Morse sequence. Important tunneling features are revealed form such arrangements. It is noted that the tunneling band spectrum could be fragmented by tailoring the shape of the barriers in the structure. Results for the transmission coefficients and the current densities are compared with the corresponding periodic and single shape barrier arrangements. The quasi-periodic structure consisting of the rectangular and triangular barrier shapes is suggested to be more suitable for the electronic and opto-electronic devices due to its high negative differential conducting effect.     

Under what kind of parametric fluctuations is spatiotemporal regularity the most robust?

It was observed that the spatiotemporal chaos in lattices of coupled chaotic maps was suppressed to a spatiotemporal fixed point when some fractions of the regular coupling connections were replaced by random links. Here we investigate the effects of different kinds of parametric fluctuations on the robustness of this spatiotemporal fixed point regime. In particular we study the spatiotemporal dynamics of the network with noisy interaction parameters, namely fluctuating fraction of random links and fluctuating coupling strengths. We consider three types of fluctuations: (i) noisy in time, but homogeneous in space; (ii) noisy in space, but fixed in time; (iii) noisy in both space and time. We find that the effect of different kinds of parametric noise on the dynamics is quite distinct: quenched spatial fluctuations are the most detrimental to spatiotemporal regularity; spatiotemporal fluctuations yield phenomena similar to that observed when parameters are held constant at the mean value, and interestingly, spatiotemporal regularity is most robust under spatially uniform temporal fluctuations, which in fact yields a larger fixed point range than that obtained under constant mean-value parameters.