In this article a unified approach is presented to hypertopologies on collections of nonempty closed subsets of a Hausdorff uniform space generated by a saturated and separating family of pseudo-metrics. One identifies here a suitable topology on the family of proper, convex and lower semicontinuous functions defined on a Hausdorff locally convex space for which the Young Fenchel transform is bicontinuous. This improves a well known result due to Mosco, Joly and Beer. 相似文献
A series of novel 2‐substituted benzimidazole and benzoxazole derivatives as a potential antimicrobial and antioxidant agent were synthesized via coupling of N‐methyl‐o‐phenylenediamine or 2‐amino‐phenol with aromatic aldehyde and acid in the presence of polyphosphoric acid as an efficient catalyst as well as solvent by conventional method in short reaction times with excellent yield. The newly synthesized benzimidazole and benzoxazole derivatives were evaluated for antimicrobial and antioxidant activity and exhibited excellent to good activities compared to the standard drugs. Furthermore, the theoretical predictions based on molecular docking against microbial DNA gyrase could provide an insight into the plausible mechanism of action and establish a link between the observed antimicrobial activity and the binding affinity shedding light on specific thermodynamic (bonded and nonbonded) interactions governing the activity. Furthermore, the synthesized compounds were analyzed for absorption, distribution, metabolism, and excretion properties and exhibited potential properties to build up as good oral drug candidates. 相似文献
Rhodamine-19 (Rh-19) incorporated three types of sol–gel samples (mentioned as dope route-I, dope route-II and dip method) were prepared by using two different methods of dye impregnation. The photophysical properties of all the three types of Rh-19 incorporated sol–gel solids were studied by using the UV–Visible absorption and the fluorescence spectroscopy. A single photon counting technique was used to estimate the lifetime of fluorescent species. From the study of fluorescence spectra, the coexistence of dimers (fluorescent and non-fluorescent both) and monomer of Rh-19 was observed. The photophysical properties of Rh-19 were found to be the best in dip sample, medium in dope route-II sample and low in dope route-I sample. After studying photophysical properties, the samples were subjected to laser study under nitrogen laser pumping at 337.1 nm at the rate of 1.5 Hz in transverse dye laser cavity. The highest laser efficiency and photostability of the dye were observed in dip sample, medium in dope route-II sample and small in dope route-I sample. A comparison between photophysical properties and laser performance of these materials showed a very good correlation. 相似文献
A simple method has been described to remove catalyst from the copper mediated atom transfer radical polymerization (ATRP) of benzyl methacrylate and methyl methacrylate in anisole at 25 °C using hydrated natural clay (sodium montmorillonite, Na‐clay). The method consists of (1) addition of hydrated clay (CuI/clay ≈ 5 wt.‐%) either during or after the polymerization, (2) oxidation of catalyst complex by exposing the terminated reaction mixture in air, and (3) filtration to obtain catalyst free polymer solution. A strong coordination of CuBr‐ligand complex onto hydrated clay (10 wt.‐% < H2O/clay < 30 wt.‐%) upon oxidation resulted in polymers with no or insignificant residual catalyst (<1.74 ppm), as determined by UV‐vis and atomic absorption spectroscopy. The recovered clay exhibited expanded intercalary layers and absence of polymer within it.
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a novel class of oral anti-diabetic agents used in the treatment of type 2 diabetes mellitus and work to enhance the effect of incretin hormones. There has been significant research on wide range of analytical techniques that could be useful in the estimation of DPP-4 inhibitors in formulations and biological matrices. Analytical methods such as ultraviolet (UV) spectrophotometry, mass spectroscopy, NMR spectroscopy, HPLC, high pressure thin layer chromatography, ultra performance liquid chromatography, liquid chromatography?mass spectrophotometry and capillary zone electrophoresis have been reported for the estimation of DPP-4 inhibitors in single and/or in combination with other drugs. This comprehensive review covers most of the spectrophotometric and chromatographic methods described for the determination of sitagliptin, alogliptin, vildagliptin, linagliptin, saxagliptin and teneligliptin in pure forms, in different pharmaceutical dosage forms and biological fluids. From the review it can be deduced that a large number of chromatographic methods have been developed, and HPLC-UV methods have been commonly used in the detection and evaluation of DPP-4 inhibitors. 相似文献
Hexacyclo[6.5.0.02,7.04,12.05,10.09.13]tridecane (HCTD) contains two four-membered, two five-membered and two six-membered rings fused into a cage structure which contains about 77.0 kcal/mol of strain energy. Attempts to prepare the thioketal from the diketone of HCTD led to a skeletal rearrangement to produce a cage with one four-membered, four five-membered, and two six-membered rings fused into a cage (RHCTD). The corresponding RHCTD hydrocarbon has a strain energy 13.7 kcal/mol less than that of the starting tridecane (HCTD) which provides the driving force for the rearrangement. The X-ray structures of two HCTD derivatives and one RHCTD derivative are reported. The bond lengths in the three reported structures are normal for cages of this type. The structure of tetracyclo[6.3.0.03,7.04,11]undecane-5,10-dione mono(ketene 1,3-propanedithioacetal) is discussed also. 相似文献
A simple reverse phase liquid chromatographic method was developed for the quantitative determination of desipramine hydrochloride and its related impurities in bulk drugs which is also stability-indicating. During the forced degradation at hydrolysis, oxidative, photolytic and thermal stressed conditions, the degradation results were only observed in the oxidative stress condition. The blend of the degradation product and potential impurities were used to optimize the method by an YMC Pack Pro C18 stationary phase. The LC method employs a linear gradient elution with the water–acetonitrile–trifluoroacetic acid as mobile phase. The flow rate was 1.0 mL min?1 and the detection wavelength 215 nm. The stressed samples were quantified against a qualified reference standard and the mass balance was found close to 99.0% (w/w) when the response of the degradant was considered to be equal to the analyte (i.e. desipramine). The developed RP-LC method was validated in agreement with ICH requirements. 相似文献
Silicon substrates with (100) orientation were modified with amino-silane self-assembled monolayer (SAM) to provide amino (NH(2)) moieties at the substrate surface. Self-organization of polyaniline during chemical polymerization, on this modified surface, leads to the growth of highly oriented films at the substrate-polymer interface. The morphology studied using scanning electron microscopy and atomic force microscopy revealed the formation of polymer film with well faceted pyramidal crystallites. XPS and FTIR spectroscopy were used to analyze the chemical structure of the film. X-ray diffraction measurements show the crystalline nature of the polyaniline, whose lattice parameters are in agreement with the reported values. This study underlines the importance of a SAM in deciding the structure and morphology of the deposited polymer. 相似文献
Rhodamine-6G (Rh-6G) is embedded in sol-gel glass samples which have been prepared by three different methods namely: 1) using
HCl as catalyst and glycerol as Drying Control Chemical Additive (DCCA), 2) using HCl as catalyst at 60 °C and drying at room
temperature and 3) using HCl as catalyst at 60 °C and heated at 600 °C for 3 h. Comparative studies of spectroscopic and lasing
properties of the three types of Rh-6G containing samples were carried out with the lapse of time upto 8 months. Photostability
of Rh-6G containing sol-gel samples is measured in terms of half life under Nitrogen laser pumping as number of pulses of
N2 laser necessary to reduce the dye laser intensity to 50% of the original value and value is 7500 pulses at 1.67 Hz rate.
The best performance of Rh-6G, as far as its spectroscopic and lasing properties are concerned was found in third type of
host matrices using HCl as catalyst at 60 °C and heated at 600 °C for 3 h. 相似文献