The stability constants of uranyl complexes with threonine and hydroxyproline were studied in aqueous solution at 25 and 45°C by the Calvin-Bjerrum technique. Thermodynamic stability constants have been obtained by extrapolation of the values at various ionic strengths. The values of stepwise changes in ΔG, ΔH and ΔS have been reported. 相似文献
Diagnostic ion–molecule reactions employed in tandem mass spectrometry experiments can frequently be used to differentiate between isomeric compounds unlike the popular collision-activated dissociation methodology. Selected neutral reagents, such as 2-methoxypropene (MOP), are introduced into an ion trap mass spectrometer where they react with protonated analytes to yield product ions that are diagnostic for the functional groups present in the analytes. However, the understanding and interpretation of the mass spectra obtained can be challenging and time-consuming. Here, we introduce the first bootstrapped decision tree model trained on 36 known ion–molecule reactions with MOP. It uses the graph-based connectivity of analytes'' functional groups as input to predict whether the protonated analyte will undergo a diagnostic reaction with MOP. A Cohen kappa statistic of 0.70 was achieved with a blind test set, suggesting substantial inter-model reliability on limited training data. Prospective diagnostic product predictions were experimentally tested for 13 previously unpublished analytes. We introduce chemical reactivity flowcharts to facilitate chemical interpretation of the decisions made by the machine learning method that will be useful to understand and interpret the mass spectra for chemical reactivity.We combine mass spectrometry with machine learning that is predictive and explainable using chemical reactivity flowcharts for diagnostic ion–molecule reactions.相似文献
Cobalt acetate reacts with aniline, 2-, 3- and 4-chloroanilinehydrobromides in the solid state to give the products CoBr2. 2 amine in which the acetate is replaced by bromide and the amine gets attached to the metal in a concerted step. The products have been identified by elemental, spectral and thermoanalytical methods. The kinetics of these reactions have been studied by the mass loss method. The values of energy of activation are 142.0, 41.0, 77.0 and 71.4 kJ mol?1. The greater reactivity of 2-chloro is due to ortho effect. An intermediate adduct (RNH3)2(Co(CH3COO)2Br2) has also been characterized. 相似文献
Cat2PMn(CO)5 (1, cat = ) is found to undergo carbonyl substitution reactions with phosphorus donors to give the isolable products cat2PMn(CO)4L, where L = cis-PPh3 (2); trans-PPh3 (3); cis-P(OMe)3 (4); and cis-P(OPh)3 (5). No evidence for CO insertion into the pentacoordinate PMn bond is observed. The X-ray crystal structure of 5 shows that the crystals are monoclinic, space group P21/n. The unit cell parameters are: a 10.523(2), b 25.765(5), c 13.344(2) Å, β 99.11(2)°, and Z = 4. Full matrix least squares refinement reached R= 0.054 for 3099 observed reflections. The pentacoordinate phosphorus adopts a distorted trigonal bipyramid geometry with the Mn in an equatorial position. Noteworthy is the small equatorial OPO angle of 110.1(2)°. 相似文献
We describe a practical and elegant method of constructing a thiazine ring fused with benzene under mild reaction conditions. A variety of 4-iodo-2H-benzo[e][1,2]thiazine-1,1-dioxides were prepared with high regioselectivity via a two-step process involving Pd/C-mediated C-C coupling of o-halobenzenesulfonamides with terminal alkynes, followed by iodocyclization of the resulting o-(1-alkynyl)arenesulfonamide using elemental iodine in acetonitrile. The coupling reaction was carried out using 10% Pd/C-PPh3-CuI as a catalyst system in the presence of Et3N. The process worked well for bromides and iodides, and a wide array of terminal alkynes containing alkyl and aryl substituents were employed. The iodocyclization step tolerated a variety of functional groups such as hydroxy, chloro, cyano, and methoxy, producing the six-membered heterocyclic ring selectively. The resulting 4-iodo-2H-benzo[e][1,2]thiazine-1,1-dioxides participated in Sonogashira, Heck, and Suzuki reactions producing a wide range of functionally substituted benzothiazines in good yields. 相似文献
Experimental isotherms describing the adsorption of pure N2, CH4 and CO in AlPO4-11, AlPO4-17, and AlPO4-18 were determined using the volumetric method at 40°C and at 23°C (AlPO4-11 only) over a pressure range up to 123 kPa, and subsequently fitted with the Langmuir or Freundlich equations, as well
as the Flory-Huggins Vacancy Solution Theory equation. The capacities for the adsorbates investigated were found to depend
on the geometry of the sieve pore size, as well as the molecular dimensions and the polority of the adsorbate involved. At
40°C and over the investigated pressure range, AlPO4-11 and AlPO4-17 adsorbed pure CH4 in the highest amounts, while AlPO4-18 had a slightly higher capacity for pure CO.
The model parameters obtained by fitting the experimental pure-component isotherms permitted the prediction of binary adsorption
information for the CO−N2, CH4−CO, and CH4−N2 gas mixtures at 101.3 kPa total pressure, using the Extended Langmuir Model, the Ideal Adsorbed Solution Theory, and/or the
Flory-Huggins Vacancy Solution Theory for mixtures. An explanation of the behaviour predicted by each model for each adsorption
system is attempted. 相似文献
A high throughput liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of valproic acid, an antiepileptic drug, in human plasma is described. It is a rapid and sensitive isocratic reversed-phase liquid chromatography-tandem mass spectrometric method equipped with turbo ion spray (TIS) source, operating in the negative ion and pseudo selective reaction monitoring (SRM) acquisition mode to quantify valproic acid. The extraction of valproic acid and hydrochlorothiazide (IS) from the plasma involved sample treatment with phosphoric acid followed by solid-phase extraction using Waters hydrophilic-lipophilic balance (HLB) cartridge giving extracts free from endogenous interferences. Sample preparation by this method yielded very good and consistent mean recoveries of 99.73 and 74.47% for valproic acid and IS, respectively. The method was linear over the dynamic range of 2.0-200.0 μg/ml (covering entire therapeutic range) with a correlation coefficient r ≥ 0.9989. The coefficient of variance (CV, %) was 7.03% at 2.0 μg/ml (LLOQ). This method was fully validated for its accuracy, precision, recovery and matrix effect especially because the pattern of elution of all the analytes may appear as flow injection type. The analyte stability was examined under conditions mimicking the sample storage, handling and analysis procedures. The method was successfully applied for bioequivalence studies in human subject samples after oral administration of 500 mg formulations. 相似文献
Photosensitized electron transfer from a variety of singlet- and triplet-excited donors to N-methoxypyridinium salts leads to N-O bond cleavage. Hydrogen atom abstraction by the resulting methoxy radical from an added alcohol generates an alpha-hydroxy radical that reduces another pyridinium molecule, thus leading to chain propagation. For example, thioxanthone-sensitized reactions of 4-cyano-N-methoxypyridinium, P1, with several aliphatic and benzyl alcohols gave quantum yields for products formation (an aldehyde or a ketone and protonated 4-cyanopyridinium) of approximately 15-20, at reactant concentrations of approximately 0.02-0.04 M. The reaction can also be sensitized with triplet benzopheone, which in this case acts as an electron donor. Energetic limitations on chain propagation are imposed by the relationship between the oxidation potential of the alpha-hydroxy radical and the reduction potential of the pyridinium salt. The chain reactions proceed despite approximately 0.25 eV endothermicity for the electron-transfer step. Chain reactions with the harder-to-reduce 4-phenyl-N-methoxypyridinium, however, are limited in scope because of increased endothermicity for electron transfer. The thioxanthone-sensitized reaction of P1 with benzhydrol was studied in detail by a combination of steady state and transient kinetics. The bimolecular rate constants for the chain propagation reactions:hydrogen atom abstraction by the methoxy radical and electron transfer from the diphenylketyl radical to P1 are approximately 6 x 10(6) and 1.1 x 10(6) M(-1) s(-1), respectively. The kinetic data indicate that deuterium atom abstraction by the methoxy radical from the solvent, acetonitrile-d(3), is a dominant chain-terminating process. Because of a large deuterium isotope effect, approximately 7, the quantum amplification is strongly suppressed when the reaction is carried out in acetonitrile. 相似文献