Characterization of Bioactive Compounds from Acacia concinna and Citrus limon,Silver Nanoparticles’ Production by A. concinna Extract,and Their Biological Properties

The applications of bioactive compounds from medicinal plants as therapeutic drugs are largely increasing. The present study selected the bioactive compounds from Acacia concinna (A. concinna) and Citrus limon (C. limon) to assess their phytochemicals, proteins, and biological activity. The plant material was collected, and extraction performed as per the standard procedure. Qualitative analysis was undertaken, and identification of functional organic groups was performed by FTIR and HPLC. Antibacterial, anticancer, antioxidant, antihyperglycemic, antihyperlipidemic, and inhibition kinetics studies for enzymes were performed to assess the different biological activities. Flavonoids and phenols were present in a significant amount in both the selected plants. A. concinna showed significant antimicrobial activity against Z. mobilis, E. coli, and S. aureus, with minimum inhibition zones (MIZ) of 24, 22, and 20 mm, respectively. C. limon strongly inhibited all the tested pathogenic bacteria with maximum and minimum MIZ of 32 and 17 mm. A. concinna silver nanoparticles also exhibited potent antimicrobial activity. Both extracts showed substantial antioxidant, antihyperlipidemic, antidiabetic, anticancer (MCF-7), and anti-urease (antiulcer) properties. To conclude, these plants can be used to treat hyperlipidemia, diabetes, cancer, and gastrointestinal ulcers. They can also serve as antimicrobial and antioxidant agents. Thus, the studied plants must be exploited cost-effectively to generate therapeutic drugs for various diseases.     

Highly efficient stereoconservative amidation and deamidation of alpha-amino acids

[reaction: see text] An overall stereoconservative protection and deprotection method of amino and carboxyl groups is presented. N-Phthaloyl N'-alkyl secondary amides of alpha-amino acids can be generated from corresponding N-phthaloyl amino acids by coupling reaction of N-alkylamines using mixed anhydride method. These secondary amides can be transformed by thermal rearrangement of intermediate nitrosoamides to O-alkyl esters with retention of configuration and excellent yields.     

Gas chromatography/mass spectrometric analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids for verification of the Chemical Weapons Convention

This paper describes the synthesis and gas chromatography/electron ionization mass spectrometric (GC/EI-MS) analysis of methyl esters of N,N-dialkylaminoethane-2-sulfonic acids (DAESAs). These sulfonic acids are important environmental signatures of nerve agent VX and its toxic analogues, hence GC/EI-MS analysis of their methyl esters is of paramount importance for verification of the Chemical Weapons Convention. DAESAs were prepared by condensation of 2-bromoethane sulfonic acid with dialkylamines, and by condensation of dialkylaminoethyl chloride with sodium bisulfite. GC/EI-MS analysis of methyl esters of DAESAs yielded mass spectra; based on these spectra, generalized fragmentation routes are proposed that rationalize most of the characteristic ions.     

Microsynthesis and electron ionisation mass spectrometric analysis of chemical weapons convention (CWC)-related O,O-dialkyl-N,N-dialkylphosphoramidates

The paper describes microsynthesis and GC/EIMS analysis of O,O-dialkyl-N,N-dialkylphosphoramidates (DADAPs). DADAPs belong to schedule 2B6 category of chemical weapons convention (CWC), as they are important markers of the chemical warfare agent Tabun and its analogues. The study was undertaken to develop a spectral database of DADAPs for verification of CWC. The reported synthetic strategy can be adopted to prepare several analogues of DADAPs simultaneously and rapidly during official proficiency tests, for the unambiguous identification of analytes within a short period. Based on the EIMS data of more than 60 compounds, fragmentation routes are proposed which explain the formation of most of the characteristic fragment ions. Subtle differences in EIMS of isomeric DADAPs are discussed to facilitate their identification.     

Distribution of Avalanche Sizes in the Hysteretic Response of the Random-Field Ising Model on a Bethe Lattice at Zero Temperature

We consider the zero-temperature single-spin-flip dynamics of the random-field Ising model on a Bethe lattice in the presence of an external field h. We derive the exact self-consistent equations to determine the distribution Prob(s) of avalanche sizes s as the external field increases from – to . We solve these equations explicitly for a rectangular distribution of the random fields for a linear chain and the Bethe lattice of coordination number z=3, and show that in these cases, Prob(s) decreases exponentially with s for large s for all h on the hysteresis loop. We find that for z4 and for small disorder, the magnetization shows a first-order discontinuity for several continuous and unimodal distributions of the random fields. The avalanche distribution Prob(s) varies as s ^–3/2 for large s near the discontinuity.     

The low-energy level structure and the electromagnetic properties of191Ir and193Ir

TheM 1 andE 2 reduced transition probabilities in¹⁹¹Ir and¹⁹⁹Ir have been calculated on the weak particle-core coupling model. The static moments of the ground state and the first three low-lying excited states have been computed. The theoretical values are in good agreement with the experimental results, in particular, the existing discrepancy between the theoretical and the experimental value for the magnetic moment of the first excited 5/2⁺ state, in both these nuclei, has been removed. The predicted sign of the quadrupole moment of the 2⁺ state in the neighbouring even-even nuclei is consistent with the results reported for Platinum nuclei. The level structure of both these nuclei has been calculated assuming the particle-core interaction to be dipole-dipole and quadrupole-quadrupole type.