Catalytic asymmetric silane alcoholysis: practical access to chiral silanes

A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated.     

Modelling of liquid-liquid metal mixing

Mathematical and physical modelling have been used interactively to predict the behaviour of two liquid metals mixing in the nosetip of a Roll-casting machine. Attention has been given to the transient development of density driven backflows due to incomplete mixing and forward transport of fluid. The results are compared with temperature and composition data obtained from metallurgical trials.Mixing reactions which may involve a simultaneous phase change (partial solidification) are also discussed in relation to the local mixing conditions.     

Development of encoded particle-polymer arrays for the accelerated screening of antifouling layers

A multiplexed screening methodology for the rapid development of antifouling polymer surfaces is presented. An array of protein resistant polymer layers with high grafting (>100 mg m(-2)) were polymerized on optically encoded particles. Multiplexed analysis showed a 97% reduction in nonspecific protein adsorption for all polymer layers created.