Aerosol-Assisted Plasma Deposition of Hydrophobic Polycations Makes Surfaces Highly Antimicrobial

The currently used multistep chemical synthesis for making surfaces antimicrobial by attaching to them hydrophobic polycations is replaced herein by an aerosol-assisted plasma deposition procedure. To this end, N,N-hexyl,methyl-PEI (HMPEI) is directly plasma-coated onto a glass surface. The resultant immobilized HMPEI coating has been thoroughly characterized and shown to be robust, bactericidal against Escherichia coli, and virucidal against human influenza virus.     

Off-shell effects in the (p, 2p) reaction using optimum geometrical conditions

Calculations of off-shell effects in the (p, 2p) reaction are presented using a fixed condition geometry and the Reid soft core potential for the proton-proton interaction. It is shown that ratios of cross sections in the chosen geometry clearly exhibit the off-shell behaviour of the p-p interaction, and that this method therefore offers a means of discriminating between phase equivalent nucleon-nucleon potentials.     

One-pot synthesis of conformationally restricted spirooxindoles

Diastereomeric three-, five- and six-membered spirocycloalkyloxindoles were successfully synthesized in a rapid and convenient manner from readily accessible starting materials in moderate to high yields using 1-methyl-3-acetonitriloxindole after a one-pot base-mediated double-alkylation strategy. It was found that the diastereoselection is dependent on the reaction conditions and the spirocycloalkyl ring size, with the 3R^∗,8R^∗ diastereomers being thermodynamically favored under the basic reaction conditions for three- and five-membered rings, and the 3R^∗,8S^∗ diastereomer in the case of six-membered rings, as predicted by DFT calculations. The relative stereochemistry was supported by 2D NMR spectra and X-ray crystal structural analysis. The conformational rigidity of the spirocycloalkyloxindoles in solution was established based on NMR experimental and theoretical DFT approaches.