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91.
A number of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles were synthesized utilizing an easy and effective N,N-bond forming heterocyclization reaction. In so doing, the substrate scope of this heterocyclization reaction, which starts with o-nitroheterocyclic aldehydes, was expanded to provide several unique heterocyclic compounds for biological screening. This work further demonstrates the versatility of this simple, base-mediated, one-pot heterocyclization method in the construction of novel heterocycles. 相似文献
92.
Park D Don AS Massamiri T Karwa A Warner B MacDonald J Hemenway C Naik A Kuan KT Dilda PJ Wong JW Camphausen K Chinen L Dyszlewski M Hogg PJ 《Journal of the American Chemical Society》2011,133(9):2832-2835
Cell death plays a central role in normal physiology and in disease. Common to apoptotic and necrotic cell death is the eventual loss of plasma membrane integrity. We have produced a small organoarsenical compound, 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid, that rapidly accumulates in the cytosol of dying cells coincident with loss of plasma membrane integrity. The compound is retained in the cytosol predominantly by covalent reaction with the 90 kDa heat shock protein (Hsp90), the most abundant molecular chaperone of the eukaryotic cytoplasm. The organoarsenical was tagged with either optical or radioisotope reporting groups to image cell death in cultured cells and in murine tumors ex vivo and in situ. Tumor cell death in mice was noninvasively imaged by SPECT/CT using an (111)In-tagged compound. This versatile compound should enable the imaging of cell death in most experimental settings. 相似文献
93.
Jonas D. Huyeng Raphael Efinger David Bruge Oliver Doll Roman J. Keding Florian Clement 《Molecules (Basel, Switzerland)》2022,27(17)
The use of sol-gel materials can simplify the industrial fabrication of high-efficiency silicon solar cells if a suitable deposition method is established. In this work, we investigate the possibilities to adapt a borosilicate glass sol-gel to provide a stable screen printing process. This material has previously been used as a boron dopant source for silicon solar cells. We now use an adjusted synthesis process, with an increased gelling time and different additives. This changes the rheological properties (i.e., the elastic and viscous moduli G′ and G″) in a way that avoids the dripping of paste through the screen and that stabilizes the material transfer in subsequent printing steps. Using this synthesis process, we were able to show a printing process with long-term stability of more than 500 prints. When comparing the adjusted to the initial paste, we show that, after thermal treatment, the obtained thin films are very similar in terms of their constitution, with a refractive index between n = 1.47 (initial) and n = 1.55 (adjusted). We also show that they provide the same amount of doping under the tested conditions (950 °C, 30 min), resulting in sheet resistances of R□ = (42.5 ± 2.6) Ω/□ (initial) and R□ = (46.4 ± 3.6) Ω/□ (adjusted). 相似文献
94.
We develop two new modified embedded-atom method (MEAM) potentials for elemental iron, intended to reproduce the experimental phase stability with respect to both temperature and pressure. These simple interatomic potentials are fitted to a wide variety of material properties of bcc iron in close agreement with experiments. Numerous defect properties of bcc iron and bulk properties of the two close-packed structures calculated with these models are in reasonable agreement with the available first-principles calculations and experiments. Performance at finite temperatures of these models has also been examined using Monte Carlo simulations. We attempt to reproduce the experimental iron polymorphism at finite temperature by means of free energy computations, similar to the procedure previously pursued by Müller et al (2007 J. Phys.: Condens. Matter 19 326220), and re-examine the adequacy of the conclusion drawn in the study by addressing two critical aspects missing in their analysis: (i) the stability of the hcp structure relative to the bcc and fcc structures and (ii) the compatibility between the temperature and pressure dependences of the phase stability. Using two MEAM potentials, we are able to represent all of the observed structural phase transitions in iron. We discuss that the correct reproductions of the phase stability among three crystal structures of iron with respect to both temperature and pressure are incompatible with each other due to the lack of magnetic effects in this class of empirical interatomic potential models. The MEAM potentials developed in this study correctly predict, in the bcc structure, the self-interstitial in the (110) orientation to be the most stable configuration, and the screw dislocation to have a non-degenerate core structure, in contrast to many embedded-atom method potentials for bcc iron in the literature. 相似文献
95.
D Zagorac K Doll JC Schön M Jansen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(35):10929-10936
Recently, we have investigated the energy landscape of PbS for many different pressures on the ab initio level by using Hartree-Fock and density functional theory to globally search for possible thermodynamically stable and metastable structures. The perhaps most fascinating observation was that besides the experimentally known modification exhibiting the rock salt structure a second minimum exists close-by on the landscape showing the low-temperature α-GeTe-type structure. In the present study, we investigate the possible reasons for the existence of this metastable modification; in particular we address the question, whether the α-GeTe-type modification might be stabilized (and conversely the rock salt modification destabilized) by steric effects of the non-bonding electron pair. 相似文献
96.
97.
Charles W. Jefford Danielle Jaggi John Boukouvalas Shigeo Kohmoto Grald Bernardinelli 《Helvetica chimica acta》1984,67(4):1104-1111
The dye-sensitized photo-oxygenation of 1,3-dimethylindole in the presence of aldehydes initially generates a zwitterionic peroxide which condenses with the carbonyl function to give the corresponding cis-fused 1,2,4-trioxanes. Acetaldehyde gives a pair of diastereomers, one of whose structures was determined by X-ray analysis (cis,cisisomer), whereas pivaladehyde gives only the cis,cis diastereomer. 相似文献
98.
Danielle Promé Catherine Deon Jean-Claude Promé Henri Wajcman Frédéric Galacteros Yves Blouquit 《Journal of the American Society for Mass Spectrometry》1996,7(2):163-167
Hemoglobin Villeparisis was found during a systematic measurement of glycated hemoglobin. Electrospray mass spectra of the globin indicate an apparently unchanged molecular weight within the error range (0.01%). The tryptic digest of the β chain shows a chromatographically abnormal βT-9 peptide. The mass-to-charge ratio value of its [M+H]+ ion, as measured by liquid secondary ionization mass spectrometry, is one mass unit lower than that of the normal βT-9. However, the electrospray mass spectrum of this peptide exhibits mainly a doubly charged ion, whereas the normal βT-9 gives a triply charged ion. None of the allowed single amino acid substitutions for a 1-u shift down (Glu → Gln, Asp → Asn, or Asn → Ile) can explain the suppression of one protonation site. This can be due only to the replacement of the internal histidine by a nonbasic residue. Thus at least two amino acid exchanges occur within the same peptide: one involves the internal histidine, and the sum of the mass shifts is ?1 u. Consideration of the βT-9 sequence and taking account for the genetic code rules, the only possibility was 11His → Tyr (+26 mass shift) associated with 14Asn → Ser (?27 mass shift). This conclusion was consistent with the tandem mass spectrum of the [M+H]+ ion and was further confirmed by chemical microsequencing. 相似文献
99.
Danielle Filiatrault H. Phuong-Nguyen Genevive Delmas 《Journal of Polymer Science.Polymer Physics》1981,19(5):763-771
Intrinsic viscosities [η] of four homopolymers, polyisobutylene (PIB), polypentene-1 (PP-1), polypentenamer (PPmer), and polydimethylsiloxane (PDMS), and of an ethylene-propylene copolymer containing 81% ethylene (81% E) have been measured at 25°C in seven linear alkanes ranging from n-C6 to n-C16 and three highly branched alkanes, 2,2,4-trimethylpentane, 2,2,4,6,6-pentamethylheptane, and 2,2,4,4,6,8,8-heptamethylnonane. Correlation of molecular orientations (CMO) in the polymers was investigated. The difference Δ[η] = [η](lin) ? [η](br) is used as a test of CMO with the supporting assumption that CMO lowers the free energy and the destruction of CMO raises it. The positive value of Δ[η], which varies from 20% to 40% for PPmer and 81% E, is indicative of orientational order in these two polymers. The negative value of Δ[η] for PDMS results from the disordering of linear alkanes by the nonordered PDMS. δ[η] is near zero for PP-1 and small for PIB implying that these two polymers are indifferent to solvent molecular shape. The variation of [η] with alkane chain length of the linear alkanes gives additional information about size and solvent quality. The dependence is small for ordered polymers due to the short range of CMO. [η] diminishes rapidly with n for PDMS probably because of the increased difference of cohesive energy between polymer and solvent. The dependence is small for PIB but very large for PP-1. The much better quality of small-molecule solvents for PP-1 may be an indication of a helicoidal conformation of this polymer in solution. 相似文献
100.
A Large ring lactone is obtained in good yield by acid catalysed cyclisation of the w-hydroxy acid precursor. 相似文献