A selective synthesis of enamines versus aziridines

The reaction of 10‐azidoacetyl‐10H‐phenothiazine with olefinic dipolarophiles depends on the reaction temperature. In refluxing toluene, a mixture of enamine and aziridine is formed in 3:1 ratio. The reaction mechanism appears to involve a Michael‐type addition of the nucleophilic N¹ azide atom to the olefinic double bond. In chloroform, a cycloaddition reaction takes place with the formation of a 4,5‐dihydro‐1,2,3‐triazole. The heating of dihydrotriazoles in toluene is accompanied by nitrogen elimination leading to a mixture of enamine and aziridine in 1:3 ratio. J. Heterocyclic Chem., 2011.     

Verification of a model to predict the influence of particle inertia and gravity on a decaying turbulent particle-laden flow

In an earlier publication some of the authors presented a theoretical model for the calculation of the influence of particle inertia and gravity on the turbulence in a stationary particle-laden flow. In the present publication the model is extended for application to a decaying suspension. Also a comparison is given between predictions made with the model and experimental data (own data and data reported in the literature) on a decaying turbulent flow with particles in a water tunnel or in a wind tunnel. For most of the experiments a prediction with reasonable accuracy and an interpretation is possible by means of the model.     

New 1,3-Disubstituted Benzo[h]Isoquinoline Cyclen-Based Ligand Platform: Synthesis,Eu3+ Multiphoton Sensitization and Imaging Applications

The development of lanthanide-based luminescent probes with a long emission lifetime has the potential to revolutionize imaging-based diagnostic techniques. By a rational design strategy taking advantage of computational predictions, a novel, water-soluble Eu³⁺ complex from a cyclen-based ligand bearing 1,3-disubstituted benzo[h]isoquinoline arms was realized. The ligand has been obtained overcoming the lack of reactivity of position 3 of the isoquinoline moiety. Notably, steric hindrance of the heteroaromatic chromophore allowed selective and stoichiometry-controlled insertion of two or three antennas on the cyclen platform without any protection strategy. The complex bears a fourth heptanoic arm for easy conjugation to biomolecules. This new chromophore allowed the sensitization of the metal center either with one or two photons excitation. The suitability as a luminescent bioprobe was validated by imaging BMI1 oncomarker in lung carcinoma cells following an established immunofluorescence approach. The use of a conventional epifluorescence microscope equipped with a linear structured illumination module disclosed a simple and inexpensive way to image confocally Ln-bioprobes by single photon excitation in the 350–400 nm window, where ordinary confocal systems have no excitation sources.     

Microwave Michaelis–Becker synthesis of diethyl phosphonates,tetraethyl diphosphonates,and their total or partial dealkylation

Diethyl phosphonates and tetraethyl alkyldiphosphonates were efficiently and rapidly prepared via the Michaelis–Becker reaction, under microwave irradiation. These compounds were then hydrolyzed to phosphonic and diphosphonic acids or selectively monodealkylated to give monoesters of phosphonic acids and symmetrical diethyl esters of diphosphonic acids. These reactions were also achieved rapidly in satisfactory yields with microwave methodology. This methodology was applied with success to the functionalization of a polymer resin. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:369–377, 2009; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20561     

A Branch-and-Bound Algorithm for Concave Network Flow Problems

In this paper a Branch-and-Bound (BB) algorithm is developed to obtain an optimal solution to the single source uncapacitated minimum cost Network Flow Problem (NFP) with general concave costs. Concave NFPs are NP-Hard, even for the simplest version therefore, there is a scarcity of exact methods to address them in their full generality. The BB algorithm presented here can be used to solve optimally single source uncapacitated minimum cost NFPs with any kind of concave arc costs. The bounding is based on the computation of lower bounds derived from state space relaxations of a dynamic programming formulation. The relaxations, which are the subject of the paper (Fontes et al., 2005b) and also briefly discussed here, involve the use of non-injective mapping functions, which guarantee a reduction on the cardinality of the state space. Branching is performed by either fixing an arc as part of the final solution or by removing it from the final solution. Computational results are reported and compared to available alternative methods for addressing the same type of problems. It could be concluded that our BB algorithm has better performance and the results have also shown evidence that it has a sub-exponential time growth.