全文获取类型
收费全文 | 115篇 |
免费 | 2篇 |
专业分类
化学 | 87篇 |
晶体学 | 1篇 |
力学 | 1篇 |
数学 | 14篇 |
物理学 | 14篇 |
出版年
2022年 | 6篇 |
2021年 | 10篇 |
2020年 | 5篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 1篇 |
2013年 | 6篇 |
2012年 | 7篇 |
2011年 | 3篇 |
2010年 | 7篇 |
2009年 | 2篇 |
2008年 | 9篇 |
2007年 | 3篇 |
2006年 | 6篇 |
2005年 | 7篇 |
2004年 | 4篇 |
2003年 | 4篇 |
2002年 | 6篇 |
2000年 | 1篇 |
1998年 | 2篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1975年 | 1篇 |
排序方式: 共有117条查询结果,搜索用时 15 毫秒
111.
Na Gao Min Lu Fernando Echeverri Bianca Laita Dalia Kalabat Mark E Williams Peter Hevezi Albert Zlotnik Bryan D Moyer 《BMC neuroscience》2009,10(1):20
Background
Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes. In particular, taste cells depolarize, activate voltage-gated sodium channels, and fire action potentials in response to tastants. Initial cell depolarization is attributable to sodium influx through TRPM5 in sweet, bitter, and umami cells and an undetermined cation influx through an ion channel in sour cells expressing PKD2L1, a candidate sour taste receptor. The molecular identity of the voltage-gated sodium channels that sense depolarizing signals and subsequently initiate action potentials coding taste information to gustatory nerve fibers is unknown. 相似文献112.
A systematic in silico approach is employed to generate an accurate model for the catalytically important oxidized state of galactose oxidase (GO) using spectroscopically calibrated hybrid density-functional theory. GO displays three distinct oxidation states: oxidized [Cu(II)-Y*], semireduced [Cu(II)-Y], and fully reduced [Cu(I)-Y], but only the [Cu(II)-Y*] and the [Cu(I)-Y] states are assumed to be involved in catalysis. We have developed multiple models for the oxidized [Cu(II)-Y*] state, whose structure has not yet been fully characterized. These models were evaluated by comparison of calculated and experimental structural data, singlet-triplet energy gaps, and electronic transitions for the antiferromagnetically coupled oxidized [Cu(II)-Y*] state. An extended model system that includes explicit solvent molecules and second coordination sphere residues (R330, Y405, and W290) is essential to obtain the correct electronic structure of the active site. The model with all the residues that have been shown to affect the radical stability and catalysis resulted in a singlet ground state with the radical centered on the Y272-C228 cofactor. The optimized structure of the oxidized GO [Cu(II)-Y*] reveals a five-coordinated square pyramidal coordination geometry very similar to [Cu(II)-Y] with considerably different Cu-ligand distances. The hydrogen-bonding interactions involving Y495 modulates the spin density distribution and the singlet-triplet energy gaps. The final model as the most reasonable structure of the oxidized [Cu(II)-Y*] state in GO reproduces the spectroscopic signature of oxidized GO. 相似文献
113.
Dalia Girdziunaite Carsten Tschierske Eva Novotna Horst Kresse Annemarie Hetzheim 《Liquid crystals》1991,10(3):397-407
The synthesis of novel liquid-crystalline heteroaromatic compounds incorporating the five membered 1,3,4-oxadiazole ring is described. Due to the bent molecular structure of the oxadiazole ring their mesophase stability is low if the heterocyclic ring occupies a central position, but it is increased if this ring is shifted to a terminal position. Dielectric measurements indicate that the 2-n-alkylthio substitutes 1,3,4-oxadiazole derivatives change the sign of the dielectric anisotropy at the phase transition from the nematic to the smectic A phase. This effect is explained by the increase of the antiparallel correlation of the molecules on formation of the smectic layers. 相似文献
114.
Aladdin Riad Sarah B. Gitto Hwan Lee Harrison D. Winters Paul M. Martorano Chia-Ju Hsieh Kuiying Xu Dalia K. Omran Daniel J. Powell Jr. Robert H. Mach Mehran Makvandi 《Molecules (Basel, Switzerland)》2020,25(24)
Theranostics are emerging as a pillar of cancer therapy that enable the use of single molecule constructs for diagnostic and therapeutic application. As poly adenosine diphosphate (ADP)-ribose polymerase 1 (PARP-1) is overexpressed in various cancer types, and is localized to the nucleus, PARP-1 can be safely targeted with Auger emitters to induce DNA damage in tumors. Here, we investigated a radioiodinated PARP inhibitor, [125I]KX1, and show drug target specific DNA damage and subsequent killing of BRCA1 and non-BRCA mutant ovarian cancer cells at sub-pharmacological concentrations several orders of magnitude lower than traditional PARP inhibitors. Furthermore, we demonstrated that viable tumor tissue from ovarian cancer patients can be used to screen tumor radiosensitivity ex-vivo, enabling the direct assessment of therapeutic efficacy. Finally, we showed tumors can be imaged by single-photon computed tomography (SPECT) with PARP theranostic, [123I]KX1, in a human ovarian cancer xenograft mouse model. These data support the utility of PARP-1 targeted radiopharmaceutical therapy as a theranostic option for PARP-1 overexpressing ovarian cancers. 相似文献
115.
Dina T. El-Sherbiny Dalia R. El-Wasseef Mohammed E. Abd El-Ghaffar Saadia M. El-Ashry 《Journal of fluorescence》2010,20(1):251-260
Simultaneous determination of two structurally related ß2 adrenergic receptor agonists namely, Ritodrine HCl (RTH) and Isoxsuprine HCl (ISP) was performed using coupling technique of synchronous fluorimetry and H-point standard addition method. Under optimum conditions, linear determination ranges were 1.48 – 14.80?×?10?6 mol L?1 and 1.54 – 15.44?×?10?6 mol L?1 for ISP and RTH respectively. RTH and ISP could be determined simultaneously without interference from each other when their concentration ratio varies from 5:1 to 1:5 in the mixed sample. The proposed method was applied to the determination of RTH and ISP in synthetic mixture of pharmaceutical samples, the accuracy and precision of the results were satisfactory. 相似文献
116.
Faten Alregeb Fawwaz Khalili Bassam Sweileh Dalia Khalil Ali 《Molecules (Basel, Switzerland)》2022,27(12)
Chelating hyperbranched polyester (CHPE) nanoparticles have become an attractive new material family for developing high-capacity nanoscale chelating agents with highly branched structures and many functional groups in the main chains and end groups that can be used to remove heavy metals from water. In this study, a hyperbranched polyester with a particle size of 180–643 nm was synthesized with A2+B3 interfacial polymerization, using dimethylmalonyl chloride as the difunctional monomer (A2) and 1,1,1-tris(4-hydroxyphenyl)ethane (THPE) as the trifunctional monomer (B3). FTIR and NMR were used to characterize the CHPE and confirm the structure. The CHPE nanoparticles were generally considered hydrophilic, with an observed swelling capacity of 160.70%. The thermal properties of the CHPE nanoparticles were studied by thermal gravimetric analysis (TGA) with 1% mass loss at temperatures above 185 °C. The XRD of the CHPE nanoparticles showed a semi-crystalline pattern, as evident from the presence of peaks at positions ~18° and 20°. The nature of the surface of the CHPE was examined using SEM. Batch equilibrium was used to investigate the removal properties of the CHPE nanoparticles towards Cd(II) ions as a function of temperature, contact time, and Cd(II) concentration. The Cd(II) ion thermodynamics, kinetics, and desorption data on the CHPE nanoparticles were also studied. 相似文献
117.