Elastoplastic Bending of Plates Resting on Elastic Subgrade under Rotational Symmetry Conditions*

An analysis of rotationally symmetric plates resting on an elastic subgrade is presented. The plates are made of an elastic, perfectly plastic material that obeys Johansen's yield condition and associated flow rule. The analysis is simplified by assuming that any plate element is either entirely elastic or entirely plastic. This assumption is practically fulfilled for a sandwich plate. Differential equations that describe the behavior of plastic zones during the deformation process are derived and solved in closed form. Examples of solutions for uniformly loaded circular plates are given.     

What Is the Mechanism Driving the Reduction of Cardiovascular Events from Glucagon-like Peptide-1 Receptor Agonists?—A Mini Review

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are considered the standard of care for type 2 diabetes in many countries worldwide. These molecules have profound anti-hyperglycaemic actions with a favourable safety profile. They are now being considered for their robust cardiovascular (CV) protective qualities in diabetic patients. Most recent CV outcome trials have reported that GLP-1 RAs reduce major adverse cardiovascular events (MACE). Furthermore, the GLP-1 RAs seem to target the atherosclerotic CV disease processes preferentially. GLP-1 RAs also improve a wide range of routinely measured surrogate markers associated with CV risk. However, mediation analysis suggests these modest improvements may contribute indirectly to the overall anti-atherogenic profile of the molecules but fall short in accounting for the significant reduction in MACE. This review explores the body of literature to understand the possible mechanisms that contribute to the CV protective profile of GLP-1 RAs.     

Novel fluoroimmunoassay for ovarian cancer biomarker CA-125

Cancer antigen 125 (CA-125) is a glycoprotein biomarker that denotes the presence of ovarian and reproductive cancers in women, with serum concentrations of CA-125 greater than 35 U/ml considered indicative of potential malignancies. A fluorescent immunoassay recently developed in our laboratory employing the ALYGNSA antibody-orientation system has been used to measure CA-125 levels. This system displayed significantly increased sensitivity with a detection limit of 1.5 U/ml compared to that of a commercial CA-125 enzyme-linked immunosorbent assay (15 U/ml) This tenfold lower level of detection of the ALYGNSA CA-125 assay should permit better identification and monitoring of ovarian cancer.     

On subordination of some analytic functions

We define V (α, β) (α < 1 and β > 1), the new subclass of analytic functions with bounded positive real part, \(V\left( {\alpha ,\beta } \right): = \left\{ {f \in A:\alpha < \operatorname{Re} \left\{ {{{\left( {\frac{z}{{f\left( z \right)}}} \right)}^2}f'\left( z \right)} \right\} < \beta } \right\}\), and study some properties of V (α, β). We also study the class U (γ) (γ > 0): \(u\left( \gamma \right): = \left\{ {f \in A:\left| {{{\left( {\frac{z}{{f\left( z \right)}}} \right)}^2}f'\left( z \right)} \right| - 1 < \gamma } \right\}\), where A is the class of normalized functions.     

An improvement of Ozaki’s P-valent conditions

The old result due to[Ozaki,S.:On the theory of multivalent functions Ⅱ.Sci.Rep.Tokyo Bunrika Daigaku Sect.A,45-87(1941)],says that if f(z) = z~p + ∑_(n=p+1~(a_nz~n))~∞ is analytic in a convex domain D and for some real α we have Re{exp(iα)f~((p))(z)} 0 in D,then f(z) is at most p-valent in ED.In this paper,we consider similar problems in the unit disc B = {z ∈ C:|z| 1}.     

可溶性聚酰亚胺类偶氮高分子的合成与表征

用聚合物的后重氮偶合方法合成了以可溶性聚酰亚胺为主链 ,偶氮生色团为侧基的新型偶氮高分子 ,并通过引入线性长链烷烃侧基来提高聚合物的溶解性 .采用红外光谱、氢核磁共振、紫外光谱和热分析等手段 ,对产物的结构、热性能及光学性能等进行了表征 .该聚合物膜在氩离子干涉激光的照射下形成正弦波形的表面起伏光栅 ,起伏深度可达 200nm.