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31.
Vernica Ibez Gaspar Jasmin McCaul Hilary Cassidy Craig Slattery Tara McMorrow 《Molecules (Basel, Switzerland)》2021,26(20)
The natural compound curcumin has been shown to have therapeutic potential against a wide range of diseases such as cancer. Curcumin reduces cell viability of renal cell carcinoma (RCC) cells when combined with TNF-related apoptosis-inducing ligand (TRAIL), a cytokine that specifically targets cancer cells, by helping overcome TRAIL resistance. However, the therapeutic effects of curcumin are limited by its low bioavailability. Similar compounds to curcumin with higher bioavailability, such as demethoxycurcumin (DMC) and 3,5-bis(2-fluorobenzylidene)-4-piperidone (EF24), can potentially have similar anticancer effects and show a similar synergy with TRAIL, thus reducing RCC viability. This study aims to show the effects of DMC and EF24 in combination with TRAIL at reducing ACHN cell viability and ACHN cell migration. It also shows the changes in death receptor 4 (DR4) expression after treatment with these compounds individually and in combination with TRAIL, which can play a role in their mechanism of action. 相似文献
32.
A Mukherjee M Dasgupta DJ Hinde CR Morton AC Berriman RD Butt JO Newton H Timmers 《Pramana》2001,57(1):195-198
Fusion cross-sections for the 7Li + 12C reaction have been measured at energies above the Coulomb barrier by the direct detection of evaporation residues. The heavy
evaporation residues with energies below 3 MeV could not be separated out from the α-particles in the spectrum and hence their
contribution was estimated using statistical model calculations. The present work indicates that suppression of fusion cross-sections
due to the breakup of 7Li may not be significant for 7Li + 12C reaction at energies around the barrier. 相似文献
33.
The alternating step generator is a well-known keystream generator consisting of two stop/go clocked LFSRs, LFSR1 and LFSR2, whose clocks are controlled by another LFSR, LFSR3, which is clocked regularly. A probabilistic analysis of this generator is conducted which shows that the posterior probabilites of individual bits of the first derivatives of the regularly clocked LFSR1 and LFSR2 sequences, when conditioned on a given segment of the first derivative of the keystream sequence, can be computed efficiently in a number of probabilistic models of interest. The expected values of these probabilities, for a random keystream sequence, are derived by an approximate theoretical analysis and are also verified by systematic computer experiments. It is pointed out that these posterior probabilities can be enhanced in a resynchronization scenario and thus used for a low-complexity fast correlation attack on the two LFSRs. More generally, it is argued that even without resynchronization these probabilities may be significantly different from one half for fast correlation attacks based on iterative decoding algorithms to be successful, although with incresead complexity. A related method for computing the posterior probabilities of individual bits of the LFSR3 sequence, when conditioned on both the keystream sequence and the LFSR1 and LFSR2 sequences, is also developed. As these posterior probabilities are much more different from one half, they can be used for a low-complexity fast correlation attack on LFSR3, provided that the initial states of LFSR1 and LFSR2 are previously reconstructed. 相似文献
34.
Summary We study embeddings between torsion-free nilpotent groups having isomorphic localizations. Firstly, we show that for finitely
generated torsion-free nilpotent groups of nilpotency class 2, the property of having isomorphicP-localizations (whereP denotes any set of primes) is equivalent to the existence of mutual embeddings of finite index not divisible by any prime
inP. We then focus on a certain family Γ of nilpotent groups whose Mislin genera can be identified with quotient sets of ideal
class groups in quadratic fields. We show that the multiplication of equivalence classes of groups in Γ induced by the ideal
class group structure can be described by means of certain pull-back diagrams reflecting the existence of enough embeddings
between members of each Mislin genus. In this sense, the family Γ resembles the family N0 of infinite, finitely generated nilpotent groups with finite commutator subgroup. We also show that, in further analogy with
N0, two groups in Γ with isomorphic localizations at every prime have isomorphic localizations at every finite set of primes.
We supply counterexamples showing that this is not true in general, neither for finitely generated torsion-free nilpotent
groups of class 2 nor for torsion-free abelian groups of finite rank.
Supported by DGICYT grant PB94-0725
This article was processed by the author using the LATEX style filecljour1 from Springer-Verlag. 相似文献
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38.
Bruins EE Bauer TS den Bok HW Duif CP van Hoek WC de Lange DJ Misiejuk A Papandreou Z Sichtermann EP Tjon JA Willering HW Yeomans DM Reike H Durek D Frommberger F Gothe R Jakob D Kranefeld G Kunz C Leiendecker N Pfeiffer G Putsch H Reichelt T Schoch B Wacker D Wehrmeister D Wilhelm M Jans E Konijn J de Vries R Furget C Voutier E Arenhövel H 《Physical review letters》1995,75(1):21-24
39.
Frederick Cassidy Richard K. Olsen Roland K. Robins 《Journal of heterocyclic chemistry》1968,5(4):461-465
The bromination of certain selected purines, pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]-pyrimidines has been studied and the reactivity of these systems compared. Displacement of a carboxyl group by bromine was noted in the case of 6-carboxypyrrolo[3,2-d]-2,4-pyrimidinedione. In contrast to xanthine, 2,6-diethoxypurine readily brominated at position 8. Pyrazolo-[4,3-d]-7-pyrimidone was readily brominated at position 3. 相似文献
40.
Edward F. Cassidy Han X. Xiao Kurt C. Frisch Harry L. Frisch 《Journal of polymer science. Part A, Polymer chemistry》1984,22(10):2667-2683
Three-component IPN systems made from polyurethanes, epoxies, and poly(methacrylates) containing charge groups in the backbones of the constituent networks have been prepared. Specific attractive forces that occurred among the various networks helped to compatibilize them and aided in the formation of true homogeneous topologically interpenetrating polymer networks. These three-component polymer alloys, including full-IPN's, pseudo-IPN's, and graft-IPN's, were characterized by means of mechanical spectroscopy, electron microscopy, and stress–strain properties. In addition, some adhesion studies were carried out (lap shear strength and peel strength). A comparison of the different types of three-component polymer alloys showed that better properties were generally exhibited by the graft-IPN's and full-IPN's containing opposite charge groups. 相似文献