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41.
Matthew A. De Wit Zixi Wang Katelyn M. Atkins Kibret Mequanint Elizabeth R. Gillies 《Journal of polymer science. Part A, Polymer chemistry》2008,46(19):6376-6392
Poly(ester amide)s (PEAs) comprising α‐amino acids, diols, and diacids are promising materials for biomedical applications such as tissue engineering and drug delivery because of their tunability and potential for either hydrolytic or enzymatic degradation. Although a number of PEAs of different compositions have been reported, there is a significant need for the incorporation of amino acids with functional side chains. This will allow for the conjugation of drugs or cell signaling molecules in tissue engineering scaffolds, thus expanding the potential applications of these materials. The objective of this work was the incorporation of l ‐lysine into PEAs to provide functionalizable pendant amine groups. Thus, varying percentages of lysine were incorporated into PEAs comprised of l ‐phenylalanine, 1,4‐butanediol, and succinic acid by tuning the ratio of ε‐protected‐l ‐lysine and l ‐phenylalanine derived monomers. The polymers were characterized by nuclear magnetic resonance spectroscopy, infrared spectroscopy, size exclusion chromatography, and differential scanning calorimetry. The lysine ε‐protecting group was removed, then the reactivity of the pendant amines was demonstrated by reaction with amino acid and tri(ethylene glycol) derivatives. The degradation of thin films of polymers were studied using scanning electron microscopy and the incorporation of lysine was found to significantly accelerate both the hydrolytic and enzymatic degradation. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6376–6392, 2008 相似文献
42.
Charles W. Gillies 《Journal of Molecular Spectroscopy》1976,59(3):482-492
The microwave spectrum of cis-1,2,3-triflurocyclopropane has been investigated in the region 8–40 GHz. A fit of the oblate symmetric top spectrum gives a rotational constant of 4064.925 ± 0.022 MHz. A molecular structure was determined using the rotational constants obtained from assignments of the monodeutero species and the carbon-13 species. The molecular parameters are , , and ∠(HCF) = 112.3 ± 0.2°. The dipole moment was determined to be 3.89 ± 0.02 D. The structural parameters are compared to other substituted cyclopropyl ring structures and to molecular orbital predictions as well as to related fluorocarbons. The molecule provides another example of the effect of fluorine substitutions on shortening adjacent bonds. It is also found that nonbonded F?F distances tend to be constant. 相似文献
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44.
Gillies DG Newling B Randall EW 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2001,151(2):235-241
Stray-field techniques are reported for 31P studies of solids for a variety of compounds including bone, bone meal and calcium hydroxyapatite. Long Hahn echo trains produced by the application of many pulses were used as in the long echo-train summation technique. Double-resonance enhancements of 31P by use of both direct and indirect experiments were attempted on a sample of NH4PF6:31P[19F] double resonance produced, at most, a 26% increase in the initial level of the 31P echo signal. 相似文献
45.
Bowen ME Monguchi Y Sankaranarayanan R Vagner J Begay LJ Xu L Jagadish B Hruby VJ Gillies RJ Mash EA 《The Journal of organic chemistry》2007,72(5):1675-1680
A branched flexible linker that incorporates a fluorescent dansyl moiety was synthesized and used to connect two high affinity NDP-alpha-MSH ligands or two low affinity MSH(4) ligands. The linker was incorporated into the conjugate by solid-phase synthesis. In vitro biological evaluations showed that potency of binding to the human melanocortin 4 receptor was not diminished for linker-ligand combinations relative to the corresponding ligand alone. 相似文献
46.
A new method was developed for the conjugation of multivalent dendritic groups to polymer vesicle surfaces. 相似文献
47.
Matthew A. Dewit Annelise Beaton Elizabeth R. Gillies 《Journal of polymer science. Part A, Polymer chemistry》2010,48(18):3977-3985
Cascade degradable linear polymers offer the potential for a high degree of control over the degradation process. They comprise a backbone that is stable in the presence of an end cap, but upon removal of the end cap a cascade of intramolecular reactions is initiated that leads of depolymerization of the polymer backbone. Reported here is a new polymer backbone based on N,N′‐dimethylethylenediamine and 2‐mercaptoethanol linked by carbamates and thiocarbamates. A disulfide end cap was incorporated such that its cleavage under reducing conditions revealed the thiol of 2‐mercaptoethanol, leading to alternating cyclizations of the 2‐mercaptoethanol and N,N′‐dimethylethylenediamine moieties to provide 1,3‐oxathiolan‐2‐one and N,N′‐dimethylimidazolidinone, respectively. The degradation was monitored by 1H NMR and GPC. The expected products were observed, along with a portion of nondegradable polymer that was likely cyclic species. Overall, the results demonstrate the promise of this new class of polymers to degrade selectively in reducing environments such as hypoxic tumor tissue or the intracellular compartments of cells. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 3977–3985, 2010 相似文献
48.
The design and preparation of new polyester dendrimer, poly(ethylene oxide) hybrid systems for drug delivery and related therapeutic applications, are described. These systems consist of two covalently attached polyester dendrons, where one dendron provides multiple functional handles for the attachment of therapeutically active moieties, while the other is used for attachment of solubilizing poly(ethylene oxide) chains. By varying the generation of the dendrons and the mass of the poly(ethylene oxide) chains, the molecular weight, architecture, and drug loading can be readily controlled. The "bow-tie" shaped dendritic scaffold was synthesized using both convergent and divergent methods, with orthogonal protecting groups on the periphery of the two dendrons. Poly(ethylene oxide) was then attached to the periphery of one dendron using an efficient coupling procedure. A small library of eight carriers with molecular weights ranging from about 20 kDa to 160 kDa were prepared and characterized by various techniques, confirming their well-defined structures. 相似文献
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