Functional Binding Surface of a β‐Hairpin VEGF Receptor Targeting Peptide Determined by NMR Spectroscopy in Living Cells

In this study, the functional interaction of HPLW peptide with VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) was determined by using fast ¹⁵N‐edited NMR spectroscopic experiments. To this aim, ¹⁵N uniformly labelled HPLW has been added to Porcine Aortic Endothelial Cells. The acquisition of isotope‐edited NMR spectroscopic experiments, including ¹⁵N relaxation measurements, allowed a precise characterization of the in‐cell HPLW epitope recognized by VEGFR2.     

Statistical Model of the Explosive Fragmentation of a Ring

A model of the explosive fragmentation of a thin ring is developed which takes into account the statistical dispersion of the relative fracture deformation along the length of the ring. A formula is proposed for calculating the velocity of the boundary of the region near a plastic rupture in which the plastic flow of the ring material ceases. Methods for the numerical and analytical calculation of the average number of fragments of the ring are developed. The calculation results are compared with available experimental data.