A note on chirality in NMR spectroscopy

Using simple symmetry arguments we give proofs of the derivations of the manifestation of chirality in the chemical shift and spin-spin coupling constant in nuclear magnetic resonance and relate our proofs to earlier discussions.     

Selectivity Control in Gold‐Mediated Esterification of Methanol

The Midas touch : The low‐temperature transformation of methanol to methyl formate, formaldehyde, and formic acid is promoted by atomic oxygen adsorbed on metallic gold (see picture). The reactions occur with O‐containing Au nanoparticles formed on Au(111) upon oxidation with ozone at 200 K; the facile esterification to methyl formate occurs well below room temperature.

     

Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex

ABSTRACT: BACKGROUND: Endocannabinoids provide control over cortical neurotransmission. We investigated the developmental expression of key genes in the endocannabinoid system across human postnatal life and determined whether they correspond to the development of markers for inhibitory interneurons, which shape cortical development. We used microarray with qPCR validation and in situ hybridisation to quantify mRNA for the central endocannabinoid receptor CB1R, endocannabinoid synthetic enzymes (DAGLalpha for 2-arachidonylglycerol [2- AG] and NAPE-PLD for anandamide), and inactivating enzymes (MGL and ABHD6 for 2- AG and FAAH for anandamide) in human dorsolateral prefrontal cortex (39 days - 49 years). RESULTS: CB1R mRNA decreases until adulthood, particularly in layer II, after peaking between neonates and toddlers. DAGLalpha mRNA expression is lowest in early life and adulthood, peaking between school age and young adulthood. MGL expression declines after peaking in infancy, while ABHD6 increases from neonatal age. NAPE-PLD and FAAH expression increase steadily after infancy, peaking in adulthood. CONCLUSIONS: Stronger endocannabinoid regulation of presynaptic neurotransmission in both supragranular and infragranular cortical layers as indexed through higher CB1R mRNA may occur within the first few years of human life. After adolescence, higher mRNA levels of the anandamide synthetic and inactivating enzymes NAPE-PLD and FAAH suggest that a late developmental switch may occur where anandamide is more strongly regulated after adolescence than earlier in life. Thus, expression of key genes in the endocannabinoid system changes with maturation of cortical function.     

Electrochemical Sulphenylation/Cyclization of Quinones: A Rapid,Green, and Efficient Access to Cytotoxic Compounds

Undivided electrochemical cells enable economical preparation of sulphur-containing naphthoquinones through electrochemical sulphenylation of quinoidal compounds. The environmentally friendly and efficient protocol eliminates the use of chemical oxidants and facilitates the synthesis of the desired molecules. This approach offers an efficient and versatile method to synthesize quinones that exhibit cytotoxicity against cancer cell lines.     

ChemInform Abstract: Potential Energy Surface of SCl3‐.

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