4‐(N‐Hydroxy­ethyl‐N‐methyl­amino)­benz­aldehyde thio­semicarbazone

In the crystal structure of the title compound, C₁₁H₁₆N₄OS, the phenyl ring and the thio­semicarbazone moiety from a dihedral angle of 7.7 (1)°. The crystal structure is governed by N—H?O and O—H?S hydrogen bonds leading to the formation of a two‐dimensional network.     

含有分层损伤的复合材料加筋层合板的屈曲性态研究

基于Ｍｉｎｄｉｎ假定推导了考虑剪切的复合材料加筋层板的有限元列式,并在此基础上计算出筋间基板含嵌入分层以及筋与基板连接处含穿透分层的加筋层合板在受压缩载荷情况下的屈曲模式和临界力。本文所给出的有限元方法及结论对从事复合材料结构设计的工程人员具有参考价值。     

由醇催化转化为长链氯代烷

采用N,N-二甲基甲酰胺和正十二烷基三甲基氯化铵为催化剂,将正辛醇、正十二醇和正十六醇分别与氯化亚砜反应,得到1-氯正辛烷、1-氯正十二烷和1-氯正十六烷,收率比不用催化剂提高10%～20%,反应速度加快.产物用红外光谱和质子磁共振谱进行了结构表征.     

Light-Triggered Nitric Oxide Release by a Photosensitizer to Combat Bacterial Biofilm Infections

Bacterial biofilms are a serious global health concern, often responsible for persistent infections. New strategies to prevent and treat bacterial infections by eradication of the biofilms are urgently needed. A novel ruthenium-based compound is reported in this study that functions as both a boronic acid-decorated photosensitizer (PS) and a light-triggered nitric oxide (NO) releasing agent. The compound can selectively attach to the bacterial membrane and biofilms and it is highly potent at eradicating Pseudomonas aeruginosa biofilms through the simultaneous release of NO and reactive oxygen species (ROS). The compound, which is more effective than clinical antibiotic tobramycin, also has excellent bacterial specificity and shows no significant cytotoxicity to human cells. The results reveal potential applications of this innovative dual-functional photoactivated ruthenium compound to combat bacterial biofilm infections.