全文获取类型
收费全文 | 15793篇 |
免费 | 2583篇 |
国内免费 | 1712篇 |
专业分类
化学 | 11667篇 |
晶体学 | 195篇 |
力学 | 844篇 |
综合类 | 72篇 |
数学 | 1552篇 |
物理学 | 5758篇 |
出版年
2024年 | 60篇 |
2023年 | 319篇 |
2022年 | 564篇 |
2021年 | 561篇 |
2020年 | 639篇 |
2019年 | 651篇 |
2018年 | 579篇 |
2017年 | 511篇 |
2016年 | 739篇 |
2015年 | 782篇 |
2014年 | 984篇 |
2013年 | 1212篇 |
2012年 | 1407篇 |
2011年 | 1487篇 |
2010年 | 1064篇 |
2009年 | 910篇 |
2008年 | 1049篇 |
2007年 | 958篇 |
2006年 | 841篇 |
2005年 | 731篇 |
2004年 | 544篇 |
2003年 | 461篇 |
2002年 | 428篇 |
2001年 | 306篇 |
2000年 | 307篇 |
1999年 | 254篇 |
1998年 | 225篇 |
1997年 | 197篇 |
1996年 | 183篇 |
1995年 | 144篇 |
1994年 | 185篇 |
1993年 | 129篇 |
1992年 | 125篇 |
1991年 | 96篇 |
1990年 | 90篇 |
1989年 | 85篇 |
1988年 | 45篇 |
1987年 | 31篇 |
1986年 | 34篇 |
1985年 | 29篇 |
1984年 | 22篇 |
1983年 | 11篇 |
1982年 | 15篇 |
1981年 | 7篇 |
1980年 | 17篇 |
1979年 | 8篇 |
1976年 | 10篇 |
1975年 | 7篇 |
1974年 | 8篇 |
1973年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
271.
Hanna Fabczak PhunBum Park Stanislaw Fabczak Pill-Soon Song 《Photochemistry and photobiology》1993,57(4):702-706
Abstract— The heterotrichous ciliate, Stentor coerulus , exhibits a welll defines photophobic response to a sudden increase in the intensity of visible light. the phobic reactions usually appear with a latency perios (i.e. a time delay between the onset of the stimulus and the stop response). This latency of phobic response was significatly increased when the cells werw incubated with 8-bromo-guanosine3',5'-cyclic monophospjhate. In the presence of this nucleotide, a reduction of cell responsiveness (i.e. the number of photophobically responding cells) was also observed. similar effects were observed when cells were treated with pertussis toxin, a G-protein activity modulator, and 3'-isobutyl-methylxanthine, an inhibitor of guanosine 3', 5'-cyclic monophosphate (cGMP) phosphodiesterase. the G-protein activator fluoroaluminate and 6-anilino-5,8-quinolinedione (LY 83583) (an effective agent for lowerin cellular cGMP levels) showed opposite effects on hte cell photophobic response. These result indirectly suggesnt that the level of cytoplamic cGMP, possibly modulated by a G-protein-coupled CGMP phosphodiesterase, plays a phototreasducing role in Stentor . In addition, using an antiserum raised against bovine transducin, a cross reacting protein with an apparent molecular mass of 39 kDa was detected on immunoblots. The α-subunits of a Stentor G-protein has also been partially cloned and sequenced. However, the possible coupling between the G-protein and the putative phosphodiesterase remains to be established. 相似文献
272.
A sensitive chemiluminescence method for the determination of acetylspiramycin is presented. It is based on the greatly enhancive effect of acetylspiramycin on the chemiluminescence reaction between luminol and hydrogen peroxide in the flow system. The increase in chemiluminescence intensity was linearly proportional to the acetylspiramycin concentration in the range from 10pg·mL–1 to 2.0ng·mL–1 (r2=0.9979). The detection limit was 3pg·mL–1 (3). At a flow rate of 2.0mL·min–1, the process of determination, including sampling and washing, could be performed in 0.5 min, and the relative standard deviations of seven replicates are less than 5.0%. The proposed method was applied successfully to the determination of acetylspiramycin in pharmaceutical preparations, human urine and serum without pre-treatment. It was found that the excretive ratio of acetylspiramycin reached its maximum 2.0 hours after having been administered orally, and the excretive ratio in 12.0 hours was 8.4. 相似文献
273.
274.
Jun Zhou Jie Yang Li Qi Xuan Shen Dunru Zhu Yan Xu You Song 《Transition Metal Chemistry》2007,32(6):711-715
A novel dinuclear nickel(II) complex, [Ni2(MOBPT)2Cl2(H2O)2]Cl2 · 7H2O (MOBPT = 4-(p-methoxyphenyl) −3,5-bis(pyridine-2-yl)-1,2,4-triazole), has been synthesized and characterized by elemental analysis, IR and single crystal X-ray
diffraction methods. The crystal structure determination shows that the dinuclear Ni2N8 unit is almost planer in which each NiII ion is coordinated by four nitrogen atoms from MOBPT equatorially and a water molecule and a chloride ion axially in a distorted
octahedral geometry. Magnetic measurements reveal a relatively weak antiferromagnetic exchange in the complex. 相似文献
275.
276.
18-冠-6与Eu(fod)3+在CCl4中的化学平衡及其配合物的结构 总被引:1,自引:0,他引:1
在室温下测定了CCl_4溶液中,18-冠-6的亚甲基、Eu(fod)的t—丁基质子的PMR化学位移与溶液组成的相互关系。提出了生成配合物RS,R_2S,R_2,R_3(S为18-冠-6,R为Eu(fod)_3)的模式。求得了平衡常数值(升/摩):K_1=[RS]/([R][S])=2.O×10~5,K_2=[R_2S]/([R][RS])=1.0×10~3,Q_1=[R_2]/[R]~2=4.2×10~2,Q_2=[R_3]/([R_2][R])=4.0×10~1。并测得在配合物RS,R_2S中18-冠-6质子的平均化学位移分别为4.90,10.84(ppm,相对于纯18-冠-6); 在配合物R,R_2,R_3,RS,R_2中t-丁基质子平均化学位移分别为1.53,2.33,0.54,1.02,2.42(ppm,相对于TMS)。 根据配合物的化学位移值,并考虑分子及分子轨道的对称性、位阻等因素提出了配合物R_2,RS,R_2S的可能的结构模型。 相似文献
277.
We have performed calculations on the fullerene cage and stacked structures of neutral and ionic Si50 cluster by full-potential linear-muffin-tin-orbital molecular-dynamics (FP-LMTO-MD) method. It is found that the neutral and charged fullerene cages relax into distorted structures resembling puckered balls. Their electronic structures are remarkably similar besides their geometrical structures. However, the relaxed cages are still not so stable as the stacked structure built from tricapped trigonal prism. By comparison, for the fullerene cages and stacked structures of neutral and ionic Si60 cluster, similar characteristics are found. 相似文献
278.
碘酸钾存在下极谱催化波法测定陈皮甙 总被引:2,自引:0,他引:2
基于陈皮甙在KIO3存在下产生的极谱催化波,拟定了测定陈皮甙的新方法。在 0.55 mol/L HAc-0.01mol/L NaAc(pH 4.00±0.05)-1.0×10~(-3)mol/L KIO3缓冲溶液中,陈皮甙催化波的峰电位为-1.35 V(vs,SCE),它的一阶导数峰峰电流与陈皮甙浓度在2.6 × 10~(-7)~2.6 × 10~(-6)mol/L范围内呈线性关系(r=0.9970,n=6)。本方法比现有的电化学方法灵敏度高一个数量级。可用于直接测定中草药贯众水提液中陈皮甙含量。 相似文献
279.
G.B. Song C.Q. Han J.K. Liang Q.L. Liu F.S. Liu G.H. Rao 《Journal of solid state chemistry》2004,177(7):2394-2403
The subsolidus phase relations of the PrOx-CaO-CuO pseudo-ternary system sintered at 950-1000°C have been investigated by X-ray powder diffraction. In this system, there exist one compound Ca10Pr4Cu24O41, one Ca2Pr2Cu5O10-based solid solution, seven three-phase regions and two two-phase regions. The crystal structures of Ca10Pr4Cu24O41 and Ca2Pr2Cu5O10-based solid solution have been determined. Compound Ca10Pr4Cu24O41 crystallizes in an orthorhombic cell with space group D2h20−Cccm, Z=4. Its lattice parameters are a=11.278(2) Å, b=12.448(3) Å and c=27.486(8) Å. The crystal structure of Ca2Pr2Cu5O10-based solid solution is an incommensurate phase based on the orthorhombic NaCuO2 type subcell. The lattice parameters of the subcell of the Ca2.4Pr1.6Cu5O10 are a0=2.8246(7) Å, b0=6.3693(5) Å, c0=10.679(1) Å, and those of the orthorhombic superstructure are with a=5a0, b=b0, c=5c0. The Ca2.4Pr1.6Cu5O10 structure can also be determined by using a monoclinic supercell with space group C2h5−P21/c, Z=4, a=5a0, b=b0, and β=104.79(1)° or 136.60(1)°, V=5a0b0c0. 相似文献
280.
Microdialysis sampling coupled with liquid chromatography-electrochemical detection (LC-ED) was developed and applied to determine the interaction of thiopurine (TP) with bovine serum albumin (BSA). A nickel hexacyanoferrate (NiHCNFe) modified electrode was fabricated and used as the working electrode in LC-ED for the determination of TP. Cyclic voltammetric experiments demonstrate that this chemically modified electrode (CME) can effectively catalyze the electrooxidation of TP. The mechanism of the catalytic oxidation of TP at the CME involves an 'EC' process. In the LC-ED, the CME also shows good stability and reproducibility for the determination of TP. The limit of detection is 5.0 x 10(-7) mol l(-1) for 6-TP with a signal-to-noise ratio of 3. The utility of microdialysis as a quantitative sampling technique for in vitro studies of drug-protein interactions was studied. The microdialysis experiments were performed in phosphate buffer solution (pH 7.4) containing different molar ratios of the drug and protein at 37 degrees C. The collected microdialysis sample with unbound TP was analyzed at the NiHCNFe CME in the LC-ED. The relative recovery of TP determined in vitro is 18.3% at a perfusion rate of 1.0 microl min(-1) and the RSD is about 2.1%. The association constant and the number of binding sites on a BSA molecule calculated with the Scatchard equation are 3.72 x 10(-3) (1 mol(-1)) and 1.51, respectively. This method provides a fast, sensitive and simple technique for the study of drug-protein interactions. 相似文献