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991.
992.
F Borcan CM Soica S Ganta MM Amiji CA Dehelean O Cerga MF Munteanu 《Chemistry Central journal》2012,6(1):87
ABSTRACT: BACKGROUND: Polymers have been considered as important materials in fabrication of microstructures for various medical purposes including drug delivery. This study evaluates polyurethane as material for hollow microstructures preparation. RESULTS: Polyurethane microstructures were obtained by interfacial polyaddition combined with spontaneous emulsification and present slightly acid pH values. Scanning electron microscopy revealed the existence of irregular shapes and agglomerated microstructures. The material is heat resistant up to 280 [DEGREE SIGN]C. Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate. Mesenchymal stem cells viability presents good results for the same sample after 48 hours based on the Alamar Blue test. CONCLUSIONS: The research revealed the reduced noxiousness of this type of microstructures and consequently the possibility of their use for therapeutic purposes. 相似文献
993.
Torres Nuñez E Sobrino C Neale PJ Ceinos RM Du S Rotllant J 《Photochemistry and photobiology》2012,88(3):701-707
UVR exposure is known to cause developmental defects in a variety of organisms including aquatic species but little is known about the underlying molecular mechanisms. In this work we used zebrafish (Danio rerio) embryos as a model system to characterize the UVR effects on fish species. Larval viability was measured for embryos exposed to several UVR spectral treatments by using a solar simulator lamp and an array of UV cutoff filters under controlled conditions in the laboratory. Survival rate and occurrence of development abnormalities, mainly caudal (posterior) notochord bending/torsion, were seriously affected in UV-exposed larvae reaching values of 53% and 72%, respectively, compared with non-UV-exposed larvae after 6 days postfertilization (dpf). In order to elucidate the molecular mechanisms involved, a matricellular glycoprotein named osteonectin and the expression of a DNA-repair related gene, p53, were studied in relation to UVR exposure. The results indicate that osteonectin and p53 expression were increased under UVR exposure due to wavelengths shorter than 335 nm (i.e. mainly UVB) and 350 nm (i.e. short UVA and UVB), respectively. Furthermore, parallel experiments with microinjections of osteonectin-capped RNA showed that malformations induced by osteonectin overexpression were similar to those observed after a UVR exposure. Consequently this study shows a potential role of osteonectin in morphological deformities induced by solar UV radiation in zebrafish embryos. 相似文献
994.
Hartenfeller M Eberle M Meier P Nieto-Oberhuber C Altmann KH Schneider G Jacoby E Renner S 《Journal of chemical information and modeling》2012,52(5):1167-1178
In the search for new bioactive compounds, there is a trend toward increasingly complex compound libraries aiming to target the demanding targets of the future. In contrast, medicinal chemistry and traditional library design rely mainly on a small set of highly established and robust reactions. Here, we probe a set of 58 such reactions for their ability to sample the chemical space of known bioactive molecules, and the potential to create new scaffolds. Combined with ~26,000 common available building blocks, the reactions retrieve around 9% of a scaffold-diverse set of compounds active on human target proteins covering all major pharmaceutical target classes. Almost 80% of generated scaffolds from virtual one-step synthesis products are not present in a large set of known bioactive molecules for human targets, indicating potential for new discoveries. The results suggest that established synthesis resources are well suited to cover the known bioactivity-relevant chemical space and that there are plenty of unexplored regions accessible by these reactions, possibly providing valuable "low-hanging fruit" for hit discovery. 相似文献
995.
Daiane Cristina Sass Vladimir Constantino Gomes Heleno Jader da Silva Barbosa Gustavo Oliveira Morais Fernando Batista Da Costa Mauricio Gomes Constantino 《Tetrahedron letters》2013,54(7):625-627
The conversion of a germacranolide structure (tagitinin C) into a furanoheliangolide one (diversifolin) was achieved by hydride conjugate addition using Stryker’s reagent. 相似文献
996.
Selective oxidation using gold 总被引:1,自引:0,他引:1
This critical review covers the recent development of the catalytic properties of gold in the selective oxidation of organic compounds, highlighting the exciting contribution to the art of catalysis. The unique, outstanding properties of nanometre-scale particles of gold, a biocompatible non-toxic metal, have allowed the development of a new generation of stable and selective catalysts for the conversion of many organic feedstocks to valuable chemicals. A critical discussion of the results of different research groups is presented along with attempts to correlate the catalytic properties with catalyst morphology in non-equivalent series of experiments.Particular emphasis has been given to the international efforts towards optimised synthesis of products of industrial appeal such as propylene oxide, vinyl acetate monomer, cyclohexanol/cyclohexanone, gluconic acid and glyceric acid (168 references). 相似文献
997.
We have studied the effect of the addition of sodium poly(styrene sulfonate) polymers on the properties of monolayers formed by the adsorption of two carboxybetaines with different number of separation methylenes between their charged groups. Fluorescence and surface tension measurements indicate that above the critical aggregation concentration a surfactant-polymer complex of electrostatic origin is formed in bulk. The complexes have a negative charge that is repelled by the negative charge of the surfactant adsorbed at the interface; consequently, the monolayer seems to be exclusively formed by surfactant carboxybetaines. The high-frequency surface viscoelasticity of the monolayers was studied by surface dynamic light-scattering measurements. The behavior of the dilational elasticity and viscosity is explained by relaxation involving molecular reorientation within the adsorbed layer. 相似文献
998.
Fernandes DC Regasini LO Vellosa JC Pauletti PM Castro-Gamboa I Bolzani VS Oliveira OM Silva DH 《Chemical & pharmaceutical bulletin》2008,56(5):723-726
Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox. 相似文献
999.
1000.
Giulia Bonente Francesca Passarini Stefano Cazzaniga Carmine Mancone Maria Cristina Buia Marco Tripodi Roberto Bassi Stefano Caffarri 《Photochemistry and photobiology》2008,84(6):1359-1370
To avoid photodamage, photosynthetic organisms have developed mechanisms to evade or dissipate excess energy. Lumen overacidification caused by light‐induced electron transport triggers quenching of excited chlorophylls and dissipation of excess energy into heat. In higher plants participation of the PsbS protein as the sensor of low lumenal pH was clearly demonstrated. Although light‐dependent energy quenching is a property of all photosynthetic organisms, large differences in amplitude and kinetics can be observed thus raising the question whether a single common mechanism is in action. We performed a detailed study of PsbS expression/accumulation in Chlamydomonas reinhardtii and investigated its accumulation in other algae and plants. We showed that PsbS cannot be detected in Chlamydomonas under a wide range of growth conditions. Overexpression of the endogenous psbs gene showed that the corresponding protein could not be addressed to the thylakoid membranes. Survey of different unicellular green algae showed no accumulation of anti‐PsbS reactive proteins differently from multicellular species. Nevertheless, some unicellular species exhibit high energy quenching activity, suggesting that a PsbS‐independent mechanism is activated. By correlating growth habitat and PsbS accumulation in different species, we suggest that during the evolution the light environment has been a determinant factor for the conservation/loss of the PsbS function. 相似文献