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Aldrich LN Lebois EP Lewis LM Nalywajko NT Niswender CM Weaver CD Conn PJ Lindsley CW 《Tetrahedron letters》2009,50(2):212-215
General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists. 相似文献
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Gloria Dion Anne Harvey Carol Jackson Patricia Klag Jinghua Liu Craig Wright 《School science and mathematics》2001,101(8):427-438
This survey investigated the current status of calculator use in classrooms and schools. The results indicated that the prevailing policy in the sample of high schools is to allow the use of calculators during classroom learning activities and tests. Scientific calculators are more frequently used than graphing calculators in algebra I and geometry; whereas, graphing calculators are more frequently used in algebra II and precalculus/trigonometry. At the time of this survey, school policies regarding the use of graphing calculators with symbolic algebra capabilities were still not determined. 相似文献
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Nadeem A. Choudry Dimitrios K. Kampouris Rashid O. Kadara Craig E. Banks 《Electrochemistry communications》2010,12(1):6-9
We demonstrate that the electron transfer properties of disposable screen printed electrodes can be readily tailored via the introduction of a polymeric formulation into the ink used to fabricate these electrochemical platforms. This approach allows the role of the binder on the underpinning electrochemical properties to be explored and allows the electrochemical reactivity of the screen printed electrodes to be tailored from that of edge plane to basal plane of highly ordered pyrolytic graphite. 相似文献
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We show that the non-commutative semidirect product Γ of ?9 by ?3 has orientable genus 4. In other words, some Cayley graph of Γ embeds in an orientable surface of genus 4 (Euler characteristic ?6), but no Cayley graph of Γ embeds in an orientable surface of genus less than 4 (Euler characteristic greater than ?6). We also show that some Cayley graph of Γ embeds in a (non-orientable) surface of Euler characteristic ?3, but no Cayley graph of Γ embeds in a surface of Euler characteristic greater than ?3. Γ is the first known example of a group whose orientable Euler characteristic and non-orientable Euler characteristic differ by more than 1. Our results also complete the determination of the orientable genus of each group of order less than 32. 相似文献
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Venkatesh Vasudevan Robert D. Cook Ronald K. Hanson Craig T. Bowman David M. Golden 《国际化学动力学杂志》2008,40(8):488-495
The reaction between methyl and hydroxyl radicals has been studied in reflected shock wave experiments using narrow‐linewidth OH laser absorption. OH radicals were generated by the rapid thermal decomposition of tert‐butyl hydroperoxide. Two different species were used as CH3 radical precursors, azomethane and methyl iodide. The overall rate coefficient of the CH3 + OH reaction was determined in the temperature range 1081–1426 K under conditions of chemical isolation. The experimental data are in good agreement with a recent theoretical study of the reaction. The decomposition of methanol to methyl and OH radicals was also investigated behind reflected shock waves. The current measurements are in good agreement with a recent experimental study and a master equation simulation. © 2008 Wiley Periodicals, Inc. 40: 488–495, 2008 相似文献
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Jonathan A. Batten Craig A. Ellis Thomas A. Fethertson 《Chaos, solitons, and fractals》2008,36(5):1126-1140
This study employs the classical and modified rescaled adjusted range statistic (R/S statistic) to investigate the sensitivity of the long-term return anomaly observed on the Dow Jones Industrial Average (DJIA) to sample and method bias. Daily data from 1/1/1970 to 17/3/2004 is used with sub-periods identified based on sign shifts in the mean returns as well as the October 1987 crash. The return series are also filtered to accommodate autoregressive conditional heteroskedastic (ARCH) innovations and short-term dependencies. Hurst exponent and V-statistic values for each of the filtered series for the whole sample and sub-periods are estimated, while polynomial regression techniques are applied to plot the V-statistics. These plots show oscillating cycles of varying lengths. Overall, we find the null hypothesis of no long-term dependence is accepted for the whole sample and every sub-period using the modified rescaled range test, but not necessarily using the classical rescaled adjusted range test. The later test does, however, reveal episodes of both positive and negative dependence over the various sample periods, which have been reported by other researchers. 相似文献