A generalized Dedekind-Mertens lemma and its converse

We study content ideals of polynomials and their behavior under multiplication. We give a generalization of the Lemma of Dedekind-Mertens and prove the converse under suitable dimensionality restrictions.

     

Hypocholesterolemic agent compactin. an alternative diels-alder strategy for the synthesis of the hexahydronaphthalene portion

The synthesis of the hexahydronaphthalene segment (4) of compactin (1) has been accomplished in a short sequence (8 steps from 9) featuring the intramolecular Diels-Alder cycloaddition of 7b.     

Nonlocality in the Expanding Infinite Well

According to D. Bohm's interpretation of quantum mechanics, a particle always has a well-defined spatial trajectory. A change in boundary conditions can nonlocally change that trajectory. In this note we point out a striking instance of this phenomenon that is easy to understand qualitatively.     

Amidrazones V. thermolysis of N1-benzyl-substituted amidrazone ylides

Thermolysis of 1,1-dimethyl-1-benzyl-2-(iminophenylmethyl)hydrazinium hydroxide inner salt gave dimethylamine, 2,4,6-triphenyl-s-triazine and 2,4,6-triphenyl-1,2-dihydro-s-triazine.     

Lariat ethers. VI. Evidence for intramolecular chelation in sodium and potassium cation binding by 15-crown-5, carbon-pivot lariat ethers

The first compelling evidence for intramolecular sidearm involvement in sodium and potassium cation complexation by carbon-pivot lariat ethers is presented.     

Studies of methoxymethyl-directed metalation

To explore the use of methoxymethyl groups to elaborate simple benzenoid precursors to more complex polyketide-derived natural products, the reaction of phenolmetoxymethyl ether $\text{ortho}$-anion was investigated with a number of electrophiles.     

Thermally induced optical bistability in CdHgTe

We report optical bistability in a room temperature, uncoated Cd_0.185Hg_0.815Te etalon using a cw CO₂ laser at 10.6 μm. The results are consistent with a band gap resonant, dispersive nonlinearity induced by a thermal shift of the band gap energy through interband and free carrier absorption. A refractive index temperature coefficient, dn/dT ～ ? 1 × 10^-3K^-1 was measured, and bistability was observed at incident powers of 20 mW.     

Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality

Diketopiperazines (DKPs) are a common motif in various biologically active natural products, and hence they may be useful scaffolds for the rational design of receptor probes and therapeutic agents. We constructed a new bicyclic scaffold that combines a DKP bridged with a 10-membered ring. In this way we obtained a three-dimensional molecular skeleton, with several amendable sites that provide a starting point to design a new combinatorial library having diverse substituent groups. Structural variation is based upon the flexibility of alkylation of the nitrogen atoms of the DKP and on the side-chain olefin. We obtained a 10-membered secondary ring through a ring-closure metathesis reaction using the second generation Grubbs catalyst. Rings containing both O-ethers and S-ethers were compared. N-Alkyl or arylalkyl groups were introduced optionally at the two Nalpha-atoms. This is a general scheme that will allow us to test rings of varying sizes, linkages, and stereochemical parameters. The DKP derivatives were tested for activity in astrocytoma cells expressing receptors coupled to phospholipase C. Inhibitory effects were observed for signaling elicited by activation of human nucleotide P2Y receptors but not m3 muscarinic receptors. Compound 20 selectively inhibited calcium mobilization (IC50 value of 486 +/- 16 nM) and phosphoinositide turnover elicited by a selective P2Y1 receptor agonist, but this compound did not compete for binding of a radiolabeled nucleotide-competitive receptor antagonist. Therefore, the new class of DKP derivatives shows utility as pharmacological tools for P2Y receptors.     

Merrifield resin-supported chain transfer agents, precursors for RAFT polymerization

The modification of Merrifield resins to form chain transfer agent (CTA) precursors for reversible addition fragmentation chain transfer (RAFT) polymerization is investigated. A series of CTA precursor resins were prepared and characterized by FTIR and elemental analysis (EA). [reaction: see text]