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581.
Nistor MT Chiriac AP Vasile C Verestiuc L Nita LE 《Colloids and surfaces. B, Biointerfaces》2011,87(2):382-390
The study presents the preparation of a semi-synthetic hydrogel based on poly(N-isopropyl acrylamide-co-diethylene glycol diacrylate) inserted onto the collagen porous membrane. The synthesis of the hydrogels was performed through radical copolymerization of N-isopropyl acrylamide (NIPAM) with diethylene glycol diacrylate (DEGDA) also as crosslinking agent, using ammonium persulfate as initiator and N,N,N',N'-tetramethylethylene diamine as activator, and it was achieved in the presence of the collagen matrix. The prepared hydrogels were characterized by Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy. The swelling behaviour of the semi-interpenetrated polymer network related on the hydrogel composition, it was also evaluated. The pore sizes of the synthesized hydrogels, much larger than the typical mesh size of a conventional hydrogel, allow to consider the hybrid hydrogel based on the inserted poly(NIPAM-co-DEGDA) onto collagen fibrils as a super-porous hydrogel. 相似文献
582.
Pluempanupat W Abraham M Brecker L Wolschann P Karpfen A Arion VB Widhalm M 《The Journal of organic chemistry》2011,76(9):3222-3230
Bridging 2,3 and 2',3' positions in 2,2'-dihydroxy-1,1'-binaphthyl and 2,2'-diamino-1,1'-binaphthyl, respectively, resulted in formation of chiral O- and N-bis-tricyclic compounds accessible in 4 steps from known 3,3'-diiodo precursors. In both cases, 2-fold ring closing metathesis of tetraallyl intermediates proceeded regioselectively to give tetrahydrobinaphtho[2,3-b]oxepine and -azepine, respectively. In case of the N-mesyl-N-allyl precursor, three, at room temperature separable, rotamers were isolated and characterized by NMR spectroscopy and X-ray structure determination. Their interconversion (process I) was followed by NMR, yielding rate constants and thermodynamic parameters. The rotamers with either C(1) or C(2) symmetry were stereospecifically cyclized to conformatively moderately stable bis-sulfonamides. Also in this case, the kinetics of their interconversion (process II) was investigated and from two of them the crystal structure was determined. Processes I and II were investigated by a DFT method, M06-2X, to gain insight into electronic and steric peculiarities responsible for the remarkable conformative stabilities. Transition state geometries and energies were calculated and compared with empirical data. 相似文献
583.
584.
Désirée Sauter Martin Schröter Christoph Frey Cornelia Weber Ulrike Mersdorf Jan-Willi Janiesch Ilia Platzman Joachim P. Spatz 《Macromolecular bioscience》2023,23(8):2200437
Imitation of cellular processes in cell-like compartments is a current research focus in synthetic biology. Here, a method is introduced for assembling an artificial cytoskeleton in a synthetic cell model system based on a poly(N-isopropyl acrylamide) (PNIPAM) composite material. Toward this end, a PNIPAM-based composite material inside water-in-oil droplets that are stabilized with PNIPAM-functionalized and commercial fluorosurfactants is introduced. The temperature-mediated contraction/release behavior of the PNIPAM-based cytoskeleton is investigated. The reversibility of the PNIPAM transition is further examined in bulk and in droplets and it could be shown that hydrogel induced deformation could be used to controllably manipulate droplet-based synthetic cell motility upon temperature changes. It is envisioned that a combination of the presented artificial cytoskeleton with naturally occurring components might expand the bandwidth of the bottom-up synthetic biology. 相似文献
585.
Ralf Landgraf Jörn Ihlemann Sebastian Kolmeder Alexander Lion Helena Lebsack Cornelia Kober Werner Schmölz Thomas R. Blattert 《PAMM》2014,14(1):121-122
This contribution deals with the simulation based investigation of processes related to the surgical treatment of vertebroplasty. In this regard, a simulation framework has been developed, which includes the generation of microstructural computer models of cancellous bone structures, the simulation of bone cement injection by computational fluid dynamics (CFD) methods and finite element (FE) simulations of bone cement curing processes. The modelling and computation strategy is illustrated and different material modelling approaches for the representation of acrylic bone cements as a non-linear fluid and a non-linear viscoelastic solid with curing dependent properties are outlined. (© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
586.
Cornelia Kasper 《Nachrichten aus der Chemie》2001,49(9):1073-1075
587.
588.
John Peter Coats Rémy Cochereau Ionel Adrian Dinu Daniel Messmer Flavien Sciortino Cornelia. G. Palivan 《Macromolecular bioscience》2023,23(8):2200474
Polymeric nano- and microscale materials bear significant potential in manifold applications related to biomedicine. This is owed not only to the large chemical diversity of the constituent polymers, but also to the various morphologies these materials can achieve, ranging from simple particles to intricate self-assembled structures. Modern synthetic polymer chemistry permits the tuning of many physicochemical parameters affecting the behavior of polymeric nano- and microscale materials in the biological context. In this Perspective, an overview of the synthetic principles underlying the modern preparation of these materials is provided, aiming to demonstrate how advances in and ingenious implementations of polymer chemistry fuel a range of applications, both present and prospective. 相似文献