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301.
Three new brominated diterpenes (1, 2, 8), along with six previously reported metabolites (3-7, 9), were isolated from the organic extract of Sphaerococcus coronopifolius, collected in Palaiokastritsa bay at the west coasts of Corfu Island. The structures of the new natural products, as well as their relative stereochemistry, were established by means of spectral data analyses, including 2D experiments. The absolute stereochemistry of 2 and 4 as well as the structure revision of the previously reported metabolite 3 were established by X-ray crystallographic analyses. The cytotoxicity of the isolated metabolites was evaluated against the NSCLC-N6-L16 and A549 human lung cancer cell lines.  相似文献   
302.
A mathematical model for transient contaminant transport resulting from the dissolution of a single component nonaqueous phase liquid (NAPL) pool in two-dimensional, saturated, homogeneous porous media was developed. An analytical solution was derived for a semi-infinite medium under local equilibrium conditions accounting for solvent decay. The solution was obtained by taking Laplace transforms to the equations with respect to time and Fourier transforms with respect to the longitudinal spatial coordinate. The analytical solution is given in terms of a single integral which is easily determined by numerical integration techniques. The model is applicable to both denser and lighter than water NAPL pools. The model successfully simulated responses of a 1,1,2-trichloroethane (TCA) pool at the bottom of a two-dimensional porous medium under controlled laboratory conditions.Notation a,a 1 defined in (45a) and (45b), respectively - b defined in (45c) - b vector of true model parameters (n×1) - vector of estimated model parameters (n×1) - c liquid phase solute concentration (solute mass/liquid volume), M/L3 - c s aqueous saturation concentration (solubility), M/L3 - C dimensionless liquid phase solute concentration, equal toc/c s - molecular diffusion coefficient, L2/t - e effective molecular diffusion coefficient, equal to / *, L2/t - D x longitudinal hydrodynamic dispersion coefficient, L2/t - D z hydrodynamic dispersion coefficient in the vertical direction, L2/t - e random vector with zero mean (m×1) - erf[x] error function, equal to (2/ 1/2) - f vector of fitting errors or residuals (m×1) - Fourier operator - -1 Fourier inverse operator - g vector of model simulated data (m×1) - k mass transfer coefficient, L/t - average mass transfer coefficient, L/t - K d partition or distribution coefficient (liquid volume/solids mass), L3/M - pool length, L - o distance between the pool and the origin of the specified Cartesian coordinate system, L - Laplace operator - -1 Laplace inverse operator - m number of observations - M Laplace/Fourier function defined in (38) - n number of model parameters - N Laplace/Fourier function defined in (39) - p defined in (46) - Pe x Péclet number, equal toU x /D x - Pe z Péclet number, equal toU x /D z - q defined in (47) - R retardation factor - s Laplace transform variable - S objective function - Sh local Sherwood number, equal tok/ e - Sh o overall Sherwood number, equal to l/ e - t time,t - T dimensionless time, equal toU x t/ - u dummy integration variable - u vector of independent variables - U x average interstitial velocity, L/t - x spatial coordinate in the longitudinal direction, L - X dimensionless longitudinal length, equal to (x–)/ - y vector of observed data (m×1) - z spatial coordinate in the vertical direction, L - Z dimensionless vertical length, equal toz/ - Fourier transform variable - defined in (37) - defined in (50) - porosity (liquid volume/aquifer volume), L3/L3 - defined in (52a) and (52b), respectively - decay coefficient, t–1 - dimensionless decay coefficient, equal to /U x - bulk density of the solid matrix (solids mass/aquifer volume), M/L3 - dummy integration variable - * tortuosity  相似文献   
303.
Summary: A highly asymmetric P2VP58‐PAA924‐PBMA48 double hydrophilic block terpolymer exhibits a rich phase behavior as a function of pH. In acidic media (pH 1) three compartment micelles with a positively charged outer corona are formed. At high pH, the above structure is transformed into a three‐dimensional transient network constituted of hydrophobic domains interconnected with negatively charged bridging chains (PAA chains). At even higher pH (14) the network is disrupted and finally exhibits a closed loop sol–gel–sol behavior.

AFM images of P2VP58‐PAA924‐PBMA48 micellar self assemblies deposited on mica.  相似文献   

304.
Optimising production from heterogeneous and anisotropic reservoirs challenges the modern hydrocarbon industry because such reservoirs exhibit extreme inter-well variability making them very hard to model. Reasonable reservoir models can be obtained using modern geostatistical techniques, but all of them rely on significant variability in the reservoir only occurring at a scale at or larger than the inter-well spacing. In this paper we take a different, generic approach. We have developed a method for constructing realistic synthetic heterogeneous and anisotropic reservoirs which can be made to represent the reservoir under test. The main physical properties of these synthetic reservoirs are distributed fractally. The models are fully controlled and reproducible and can be extended to model multiple facies reservoir types. This paper shows how the models can be constructed and how they have been tested. Reservoir simulation results of a number of generated 3-D heterogeneous and anisotropic models show that heterogeneity, in terms of only the geometric distribution of reservoir properties, has a little effect on oil production from high and moderate quality reservoirs. However, if the effect of heterogeneity on capillary pressure is taken into account, the effect becomes striking, where varying the heterogeneity of reservoirs properties can lead to a 70 % change in the predicted oil production rate and a significant early shift of water breakthrough time. Hence, it is the heterogeneity consequences that are really substantial if not taken into account. These are very significant uncertainties for a hydrocarbon company if the heterogeneity of their reservoir is not well defined.  相似文献   
305.
Polystyrene‐block‐poly(2‐vinyl pyridine)‐block‐poly(methyl methacrylate) ABC triblock copolymers were synthesized by sequential living anionic polymerization. Their solution properties were investigated in toluene, which is a bad solvent for the middle block. Spherical micelles are formed, which consist of a poly(2‐vinyl pyridine) dense core bearing polystyrene and poly(methyl methacrylate) soluble chains at the corona. These micelles exhibit the architecture of heteroarm star copolymers obtained by “living” polymerization methods. The aggregation numbers strongly depend on the length of the insoluble P2VP middle block, thus remarkably affecting the size of the micelles.  相似文献   
306.
307.
The synthesis of 3,4-dihydroquinoxalin-2-ones via the selective reduction of aromatic, multifunctional nitro precursors catalyzed by supported gold nanoparticles is reported. The reaction proceeds through the in situ formation of the corresponding amines under heterogeneous transfer hydrogenation of the initial nitro compounds catalyzed by the commercially available Au/TiO2-Et3SiH catalytic system, followed by an intramolecular C-N transamidation upon treatment with silica acting as a mild acid. Under the present conditions, the Au/TiO2-TMDS system was also found to catalyze efficiently the present selective reduction process. Both transfer hydrogenation processes showed very good functional-group tolerance and were successfully applied to access more structurally demanding products bearing other reducible moieties such as chloro, aldehyde or methyl ketone. An easily scalable (up to 1 mmol), low catalyst loading (0.6 mol%) synthetic protocol was realized, providing access to this important scaffold. Under these mild catalytic conditions, the desired products were isolated in good to high yields and with a TON of 130. A library analysis was also performed to demonstrate the usefulness of our synthetic strategy and the physicochemical profile of the derivatives.  相似文献   
308.
Dehydroabietic Acid (DHA, 1) derivatives are known for their antiproliferative properties, among others. In the context of this work, DHA was initially modified to two key intermediates bearing a C18 methyl ester, a phenol moiety at C12, and an acetyl or formyl group at C13 position. These derivatives allowed us to synthesize a series of DHA-chalcone hybrids, suitable for structure–activity relationship studies (SARS), following their condensation with a variety of aryl-aldehydes and methyl ketones. The antiproliferative evaluation of the synthesized DHA-chalcone hybrids against three breast cancer cell lines (the estrogen-dependent MCF-7 and the estrogen-independent MDA-MB-231 and Hs578T) showed that eight derivatives (33, 35, 37, 38, 39, 41, 43, 44) exhibit low micromolar activity levels (IC50 2.21–11.5 μΜ/MCF-7). For instance, some of them showed better activity compared to the commercial anticancer drug 5-FU against MCF-7 cells (33, 41, 43, 44) and against MDA-MB231 (33 and 41). Hybrid 38 is a promising lead compound for the treatment of MCF-7 breast cancer, exhibiting comparable activity to 5-FU and being 12.9 times less toxic (SI = 22.7). Thus, our findings suggest that DHA-chalcone hybrids are drug candidates worth pursuing for further development in the search for novel breast cancer therapies.  相似文献   
309.
Four linear and four star equimolar terpolymers based on non‐ionic hydrophilic methoxy hexa(ethylene glycol) methacrylate, ionizable hydrophilic 2‐(dimethylamino)ethyl methacrylate and neutral hydrophobic methyl methacrylate were synthesized using group transfer polymerization and investigated in aqueous dilute solutions. It was found that the (ABC)n multi‐arm star terpolymers formed unimolecular micelles comprising three centrosymmetric compartments. The position of each compartment could be determined by the block sequence (ABC, ACB or BAC) at will. On the other hand, the ABC linear counterparts formed loose associates with very low aggregation numbers. It was shown that the polymer architecture (linear versus star) greatly affected the micellization phenomena of the terpolymers in selective media.

  相似文献   

310.
A two step synthetic procedure towards model coil‐rod‐coil triblock copolymers was developed. In the first step, α,ω‐bromo‐functionalized oligophenylenes (rod part) were modified to anionic bifunctional initiators. In the second step, flexible chains were grown from both ends of the rod part by an anionic polymerization procedure leading to polystyrene‐rod‐polystyrene and/or poly(2‐vinyl pyridine)‐rod‐poly(2‐vinyl pyridine) triblock copolymers. Characterization of the final products by gel permeation chromatography, NMR spectroscopy, light scattering, Raman spectroscopy and differential scanning calorimetry demonstrated that well‐defined coil‐rod‐coilblock copolymers can be synthesized.  相似文献   
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