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961.
Dongjoon Lee Jong-Chan Park Keum Sim Jung Jiyeong Kim Ji Sung Jang Sunghoon Kwon Min Soo Byun Dahyun Yi Gihwan Byeon Gijung Jung Yu Kyeong Kim Dong Young Lee Sun-Ho Han Inhee Mook-Jung 《Experimental & molecular medicine》2022,54(1):61
The deposition of beta-amyloid (Aβ) in the brain precedes the onset of symptoms such as cognitive impairment in Alzheimer’s disease (AD); therefore, the early detection of Aβ accumulation is crucial. We previously reported the applicability of the QPLEXTM Alz plus assay kit for the prescreening of Aβ accumulation. Here, we tested the specific application of the kit in a large cohort of cognitively normal (CN) individuals of varying ages for the early detection of Aβ accumulation. We included a total of 221 CN participants with or without brain Aβ. The QPLEXTM biomarkers were characterized based on age groups (1st–3rd tertile) and across various brain regions with cerebral amyloid deposition. The 3rd tertile group (>65 years) was found to be the most suitable age group for the application of our assay kit. Receiver operating characteristic curve analysis showed that the area under the curve (AUC, discrimination power) was 0.878 with 69.7% sensitivity and 98.4% specificity in the 3rd tertile group. Additionally, specific correlations between biomarkers and cerebral amyloid deposition in four different brain regions revealed an overall correlation with general amyloid deposition, consistent with previous findings. Furthermore, the combinational panel with plasma Aβ1–42 levels maximized the discrimination efficiency and achieved an AUC of 0.921 with 95.7% sensitivity and 67.3% specificity. Thus, we suggest that the QPLEXTM Alz plus assay is useful for prescreening brain Aβ levels in CN individuals, especially those aged >65 years, to prevent disease progression via the early detection of disease initiation.Subject terms: Alzheimer''s disease, Neural ageing, ELISA 相似文献
962.
遗传算法是一种模仿自然进化进程的新颖的启发式优化方法。通过它,人们可以在计算机上对所需的各种问题实施进化操作,最终产生理想的结果。遗传算法现已被广泛于计算机辅助设计、工程设计、系统模拟等领域并取得了极大的成功。本文拟对遗传算法在对大、中、小分子的构象搜寻中的应用作一较全面的综述。 相似文献
963.
Sreekar Wunnava Christina F. Dirscherl Jakub Výravský Dr. Aleš Kovařík Dr. Roman Matyášek Prof. Jiří Šponer Prof. Dieter Braun Dr. Judit E. Šponer 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(70):17581-17585
The assembly of ancient informational polymers from nucleotide precursors is the central challenge of life's origin on our planet. Among the possible solutions, dry polymerization of 3’,5’-cyclic guanosine monophosphate (3’,5’-cGMP) has been proposed as a candidate to create oligonucleotides of 15–20 units in length. However, the reported sensitivity of the reaction to the presence of cations raised questions of whether this chemistry could be relevant in a geological context. The experiments in this study show that the presence of cations is not restrictive as long as the reaction is conducted in an acidic environment, in contrast to previous reports that suggested optimal conditions at pH 9. 相似文献
964.
食物中游离态二价铁及游离态三价铁的测定 总被引:4,自引:0,他引:4
人体必需的微量元素铁的生物有效性与铁的离子价态有关。为了解食物中游离态二价铁与游离态三价铁的含量,及其在总铁中的比例,用去离子水提取食物中的游离态铁,分别用邻菲啉-氟化铵体系和硫氰酸钾体系分光光度法测定游离态二价铁与三价铁离子,结果发现动物性食物中游离态二价铁离子明显高于游离态三价铁离子,而植物性食物却相反。紫菜中游离态二价铁离子的含量是传统观念中补铁食物菠菜的25倍、猪肝的14倍,是较为理想的补铁食物。各种食物的游离态Fe2+与Fe3+之和,约占总铁的7%~93%,说明除了游离态的Fe2+和Fe3+外,尚有其他形态的铁存在,并且动物性食物较多。 相似文献
965.
Chonghao Wu Wei Ji Rui Yin Xiao Li Junbao Wang Zisu Gong Shicheng Zhang 《Optical and Quantum Electronics》2017,49(12):420
In this paper, a reconfigurable Radio over Fiber system based on optical switches, optical multimode interference power splitter and tunable optical filters is designed, which can achieve quadrature phase shift keying wireless modulation in optical domain and switch carrier frequency between 30 and 60 GHz. The scheme can make good use of bandwidth resource and realize signal transmission in fiber within 10 km. 相似文献
966.
离子交换富集-导数火焰原子吸收法测定自来水中Cu,Fe和Zn 总被引:7,自引:0,他引:7
本文研究了用 2 0 1× 7阳离子交换树脂对自来水中的微量元素进行交换富集 ,采用微量脉冲进样 导数火焰原子吸收法测定富集后溶液中的Cu ,Fe和Zn ,该方法灵敏度分别为 0 2 9,0 5 9和 0 0 6 μg·L- 1 ,精密度分别为 4 2 8% ,1 95 %和 2 2 8% ,检测限分别为 1 2 8,5 85和 0 6 8μg·L- 1 ,回收率分别为 91 13% ,10 1 34%和99 84 % ,本方法大大减少了需样量 ,简便快速 ,灵敏度高。 相似文献
967.
Jan ?echal Jind?ich Mach Stanislav Voborný Petr Kostelník Petr Bábor Ji?í Spousta Tomáš Šikola 《Surface science》2007,601(9):2047-2053
Results for deposition and thermal annealing of gallium on the Si(1 0 0)-(2 × 1) surface achieved by synchrotron radiation photoelectron spectroscopy (SR-PES) and low energy electron diffraction (LEED) are presented. In addition to deposition of Ga on a clean surface, the influence of water adsorption on the arrangement of gallium atoms was also studied. The results on Ga deposition at a higher temperature (490 °C) are consistent with a Ga ad-dimer model showing equivalent bond arrangement of all Ga atoms for coverages up to 0.5 ML. The deposition onto a surface with adsorbed water at room temperature led to a disordered gallium growth. In this case gallium atoms bind to silicon dimers already binding fragments of adsorbed water. A subsequent annealing of these layers leads to a surface structure similar to the Ga-(2 × 2), however, it is less ordered, probably due to the presence of silicon oxides formed from water fragments. 相似文献
968.
969.
通过对气吹式精密播种机田间试验资料的相关分析,发现合格指数A与|D-M|(重播指数与漏播指数之差的绝对值)之间里极显著负相关(r=-0.9312)。在对数据作进一步回归分析的基础上,本文建立了一套“由排种粒数预测排种质量”的方法。 相似文献
970.