Coulomb distortion effects on single particle exchange singularities

It is shown that Coulomb distortion modifies the single-particle exchange pole residue by a factor independent of the orbital angular momentum of the bound states involved in the exchange process. The implications of this result on the polarization observables and on recent determinations of the deuteron asymptotic D- to S-state ratio, using analyticity, are discussed.     

The 15N NMR spectra of macrocyclic compounds containing the ferrocene unit

The synthesis of a ¹⁵N enriched macrocycle containing the ferrocene unit is descibed, and the ¹⁵N NMR spectra of the macrocycle and those of its complexes with some metallic cations are reported.     

The measurement and significance of energy in acoustic-emission testing

A technique for measuring the energy sensed at an acoustic-emission transducer is presented that utilizes a squaring circuit and digital integrator. Theoretical relationships between energy and other more conventional acoustic-emission parameters, such as counts and RMS voltage, are derived for certain idealized cases. Experimental results from the following types of tests are presented: (1) unflawed tensile (‘continuous’ emission); (2) precracked stress-corrosion cracking; (3) precracked fracture toughness; and (4) fatigue-crack growth. Energy, counts, RMS-voltage, energy/event and counts/event measurements are included. In the case of unflawed tensile specimens, energy techniques appeared somewhat superior to counts. In all other cases, a direct relationship between counts and energy was obtained. Energy measurements tended to give a larger weight to higher amplitude events. Other than this, energy measurements appeared to have no advantage over counts. The theoretical relationship predicted between energy/event and count/event agreed quite well with experimental observations. Overall, the test results presented indicate that energy techniques provide no significant advantage over counting threshold crossings in cases in which crack extension in metals is the primary source of acoustic emission.     

Polyimide structure–property relationships. I. Polymers from fluorene-derived diamines

A series of fluorene and fluorenone diamines were polymerized with two aromatic dianhydrides, and the resulting polyamic acids were cyclodehydrated to aromatic polyimides. A study of the mechanical properties of the polyimide films disclosed they are among the stiffest reported to date, with an excellent retention of rigidity at elevated temperatures. Comparisons of the tensile properties and glass transition temperatures of the fluorene-derived polymer films with those from the corresponding open-chain polyimide films established that the unusual rigidity, especially at elevated temperatures, was in large part due to the contribution of the bulky, tricyclic fluorene (one) moieties in the polymer structures.     

Light intensity correlation measurements in the presence of multiple scattering

We discuss the results of a model calculation of the intensity correlation function for multiply scattered light and compare our analytic predictions with experiments.     

Lanthanide-induced shifts of diastereotopic groups

The chemical shift differences of diastereotopic protons in aliphatic acyclic alcohols, mostly of the type R? CH₂? CR′R″? (CH₂)_nOH, have been investigated. Fairly small amounts of Eu(dpm)₃ cause the spectra of these materials to simplify dramatically; indeed, even diastereotopic protons rather far removed form the hydroxyl group give discrete signals in the presence of the shift reagent. Large shift differences were realized in the γ-protons (n = 1) and the δ-protons (n = 2), particularly if R is bulky and R' and R″ have different steric requirements. Semi-quantitative conformational preferences can be determined from the data obtained.     

New inhalation anaesthetics: II. Fluorinated methyl propyl ethers

A range of fluorohalogenated methyl propyl ethers has been prepared for screening as potential inhalation anaesthetics. Many compounds tested were either convulsant or caused marked respiratory depression. Only 2,2,3,3-tetrafluoropropyl methyl ether showed good anaesthesia without side effects, but would also be expected to be flammable at clinical concentrations.     

New inhalation anaesthetics: III. Fluorinated aliphatic ethers

A range of fluorinated methyl ethyl ethers, diethyl ethers and methyl butyl ethers has been synthesised as potential inhalation anaesthetics. Seven compounds produced anaesthesia with minimal side effects in mice, and their biological testing will be reported in more detail elsewhere [1].     

Increasing peptide identification in tandem mass spectrometry through automatic function switching optimization

Comprehensive proteomic studies that employ MS directed peptide sequencing are limited by optimal peptide separation and MS and tandem MS data acquisition routines. To identify the optimal parameters for data acquisition, we developed a system that models the automatic function switching behavior of a mass spectrometer using an MS-only dataset. Simulations were conducted to characterize the number and the quality of simulated fragmentation as a function of the data acquisition routines and used to construct operating curves defining tandem mass spectra quality and the number of peptides fragmented. Results demonstrated that one could optimize for quality or quantity, with the number of peptides fragmented decreasing as quality increased. The predicted optimal operating curve indicated that significant improvements can be realized by selecting the appropriate data acquisition parameters. The simulation results were confirmed experimentally by testing 10 LC MS/MS data acquisition parameter sets on an LC-Q-TOF-MS. Database matching of the experimental fragmentation returned peptide scores consistent with the predictions of the model. The results of the simulations of mass spectrometer data acquisition routines reveal an inverse relationship between the quality and the quantity of peptide identifications and predict an optimal operating curve that can be used to select an optimal data acquisition parameter for a given (or any) sample.