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601.
Baldoli C Maiorana S Licandro E Casiraghi L Zinzalla G Seneci P De Magistris E Paio A Marchioro C 《Journal of combinatorial chemistry》2003,5(6):809-813
Different arene Cr(CO)(3) complexes were supported on a polystyrene isonitrile resin by photochemical-promoted replacement of a chromium carbonyl ligand by the NC group. The supported complexes proved to be stable and were successfully used for further transformations. In particular, the reactivity of dichlorobenzene complexes to different nucleophiles was investigated and found to be comparable with that of the parent Cr(CO)(3) complexes. 相似文献
602.
Alan R. Katritzky Clara N. Fali Irina V. Shcherbakova Sergei V. Verin 《Journal of heterocyclic chemistry》1996,33(2):335-339
1-(Azidomethyl)benzotriazole reacts with alkynes to give mixtures of isomeric 1,2,3-triazoles, whereas the interactions of 1-(azidomethyl)benzotriazole and -5-phenyl-1,2,3,4-tetrazole with alkenes proceed regioselectively to form 1,2,3-triazolines and/or aziridines and enamines in good yields. Diheterocyclosubstituted methanes thus obtained were investigated with respect to thermolysis, α-lithiation, and reactions with Grignard reagents. 相似文献
603.
Oscar Díaz Rizo Margaret Suárez Muñoz Patricia González Hernández Alina Gelen Rudnikas Katia D´Alessandro Rodríguez Clara M. Melián Rodríguez Juan R. Fagundo Castillo Nadia V. Martínez-Villegas Juan Tomás Zerquera 《Journal of Radioanalytical and Nuclear Chemistry》2018,315(1):95-101
In this work, an approach for determining both the outer dead layer thickness of the p-type coaxial HPGe detector and the inner dead layer thickness of the n-type coaxial HPGe detector was proposed by using two full energy peak area count ratios of a X-ray and a gamma ray emitted from the same radioisotope of 137Cs. Monte Carlo calculations and experimental measurements were conducted to determine these dead layer thicknesses. The results showed that the outer dead layer thickness reached 0.57 ± 0.03 mm on 06 Jan 2017 after nearly 3 years of use for the p-type detector. The inner dead layer thickness reached 1.21 ± 0.24 mm on 01 Aug 2016 after more than 3 years of operation for the n-type detector. Simulation model with the modified dead layer thicknesses was used to estimate full energy peak efficiencies and gamma spectra from seven radioactive sources. The results were in good agreement with the corresponding experimental values in the gamma energy region of interest. 相似文献
604.
Boatto G Culeddu N Testa C Neri B Brambilla G Barbosa J Cruz C 《Analytica chimica acta》2007,586(1-2):223-227
In animal production, it is consolidated the synthesis and the illegal use of growth promoters of new generation, able to skip routine screening and confirmatory analysis. In this work it is reported the nuclear magnetic resonance (NMR) and the mass spectrometry identification of a probable new adrenergic drug found in a feed premix. The substance was selectively purified on alpha 1 acid glycoprotein affinity columns; then its structure was first achieved by recording the 13C NMR spectrum that gave the total number of carbons of the molecule, successively sorted by DEPT experiments into quaternary, CH, CH2, and CH3 groups. However, the complete assignments of all resonances were derived from the bi-dimensional analysis and the crucial indications from the 1H-13C reverse experiments. Further characterisation was performed by atmospheric pressure chemical ionisation both in positive and negative ion mode, matching the molecular ion and the fragmentation pattern with those of most recently described new adrenergic agonists. After the loss of a ter-butylic group, the structure shows an internal symmetry along with the presence of Chlorine clusters. The proposed formula of the compound, the 8,8'-diamino-9,9'-dichloro-1-terbutyl-1,1',4,4-tetrahydro-5H,5'H-2,2'-bi-1-benzazepine-5,5'-dione, partially resembles that of Zilpaterol for the presence of a heterocyclic ring; Further work is in progress to characterise the structure-activity relationship. 相似文献
605.
The authors present a method to calculate free energy differences between two states A and B "on the fly" from a single molecular dynamics simulation of a reference state R. No computer time has to be spent on the simulation of intermediate states. Only one state is sampled, i.e., the reference state R which is designed such that the subset of phase space important to it is the union of the parts of phase space important to A and B. Therefore, an accurate estimate of the relative free energy can be obtained by construction. The authors applied the method to four test systems (dipole inversion, van der Waals interaction perturbation, charge inversion, and water to methanol conversion) and compared the results to thermodynamic integration estimates. In two cases, the enveloping distribution sampling calculation was straightforward. However, in the charge inversion and the water to methanol conversion, Hamiltonian replica-exchange molecular dynamics of the reference state was necessary to observe transitions in the reference state simulation between the parts of phase space important to A and B, respectively. This can be explained by the total absence of phase space overlap of A and B in these two cases. 相似文献
606.
Clara Pampillón 《Journal of organometallic chemistry》2007,692(11):2153-2159
From the carbolithiation of N,N-dimethylamino fulvene (3a) and different ortho-lithiated heterocycles (furan, thiophene and N-methylpyrrole), the corresponding lithium cyclopentadienide intermediate (4a-c) was formed. These three lithiated intermediates underwent a transmetallation reaction with TiCl4 resulting in dimethylamino-functionalised titanocenes 5a-c. When these titanocenes were tested against LLC-PK cells, the IC50 values obtained were of 240, and 28 μM for titanocenes 5a and 5b, respectively. The most cytotoxic titanocene 5c with an IC50 value of 5.5 μM is found to be almost as cytotoxic as cis-platin, which showed an IC50 value of 3.3 μM, when tested on the LLC-PK cell line, and titanocene 5c is approximately 400 times better than titanocene dichloride itself. 相似文献
607.
Mercè Claverol Delia Garijo Clara I. Grima Alberto Márquez Carlos Seara 《Computational Geometry》2011,44(5):303-318
The problem of computing a representation of the stabbing lines of a set S of segments in the plane was solved by Edelsbrunner et al. We provide efficient algorithms for the following problems: computing the stabbing wedges for S, finding a stabbing wedge for a set of parallel segments with equal length, and computing other stabbers for S such as a double-wedge and a zigzag. The time and space complexities of the algorithms depend on the number of combinatorially different extreme lines, critical lines, and the number of different slopes that appear in S. 相似文献
608.
Peralta-Bohórquez AF Quijano-Célis C Gaviria M Vanegas-López C Pino JA 《Natural product communications》2011,6(2):247-249
The chemical composition of the volatile compounds from the leaves of Lantana canescens Kunth (Verbenaceae) and L. lopez-palacii Moldenke grown in Colombia were analyzed by GC and GC/MS. One hundred and thirty-nine volatile compounds were identified in L. canescens, of which the major ones were beta-caryophyllene (13.5%), germacrene D (10.3%) and 1-octen-3-ol (8.4%). In the oil obtained from L. lopez-palacii, eighty-three compounds were identified, of which the most prominent were 1-octen-3-ol (24.4%) and beta-caryophyllene (15.2%). The in vitro antibacterial activity of the L. lopez-palacii essential oil was studied against three bacterial strains using the disc diffusion method. No antimicrobial activity was found against Escherichia coli, Enterobacter sakazakii and Listeria monocytogenes. 相似文献
609.
Li L Gomes CS Gomes PT Duarte MT Fan Z 《Dalton transactions (Cambridge, England : 2003)》2011,40(13):3365-3380
A series of zinc complexes of the general formula {[ZnCl(ArN=C(An)-C(An)=NAr)](+)}(2)[Zn(2)Cl(6)](2-) (where Ar = 2-(1-benzyl-1H-1,2,3-triazol-4-yl)phenyl 2a, 2-(1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)phenyl 2b, 2-(1-phenyl-1H-1,2,3-triazol-4-yl)phenyl 2c; An = acenaphthene backbone) were prepared by the condensation of acenaphthenequinone with the corresponding o-triazolyl-substituted anilines (2-(1-benzyl-1H-1,2,3-triazol-4-yl)aniline 1a, 2-(1-(1-phenylethyl)-1H-1,2,3-triazol-4-yl)aniline 1b, 2-(1-phenyl-1H-1,2,3-triazol-4-yl)aniline 1c) which were formed by the copper(I)-catalyzed Huisgen[3+2] dipolar cycloaddition between 2-ethynylaniline and the corresponding azides in high yields, using anhydrous ZnCl(2) as the metal template, in boiling glacial acetic acid. Zinc complexes of the type [ZnCl(ArN=C(An)-C(An)=NAr)](+)[ZnCl(3)(NCCH(3))](-) (4a-c) were synthesized by crystallisation of the corresponding complexes 2a-c in acetonitrile, at -20 °C. After removal of zinc dichloride from complexes 2a-c by the addition of potassium oxalate, in dichloromethane, the tetradentate N,N,N,N-chelating α-diimine ligands of the type ArN=C(An)-C(An)=NAr (5a-c) were obtained. The new ligand precursors and zinc complexes were characterised by elemental analysis, (1)H and (13)C{(1)H} NMR spectroscopy, two-dimensional NMR spectroscopy, and X-ray diffraction. Reaction of the ligand precursors 5a-c with [NiBr(2)(DME)], in dichloromethane, gave nickel complexes of the type [NiBr(2)(ArN=C(An)-C(An)=NAr)] (6a-c). The results of single crystal X-ray diffraction characterisation and magnetic susceptibility measurements demonstrated that nickel complexes 6a-c possess octahedral geometries around the nickel atoms with variable configurations, the Br atoms of which can be ionized when dissolved in methanol. In preliminary catalytic tests, complexes 6a-c revealed to be active as catalysts for the polymerisation of norbornene and styrene, when activated by cocatalyst MAO. The characterisation of the polymers by (1)H and (13)C{(1)H} NMR spectroscopy, gel permeation chromatography/size-exclusion chromatography (GPC/SEC) revealed that these polymers were formed by a coordination addition mechanism. 相似文献
610.
Valadez-Vega C Alvarez-Manilla G Riverón-Negrete L García-Carrancá A Morales-González JA Zuñiga-Pérez C Madrigal-Santillán E Esquivel-Soto J Esquivel-Chirino C Villagómez-Ibarra R Bautista M Morales-González A 《Molecules (Basel, Switzerland)》2011,16(3):2107-2118
Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines. 相似文献