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591.
592.
Tamoxifen is an important estrogen receptor antagonist used successfully for the treatment and prevention of breast cancer. The use of complementary and alternative medicines is an increasingly popular means for patients to participate in their own health care, and soy products, which contain phytoestrogens, have been widely promoted for possible beneficial effects on menopausal symptoms. The possibility that soy isoflavones could reduce tamoxifen efficacy has been demonstrated in animal models of post-menopausal breast cancer, but the occurrence of such an effect in women has not been explored. This paper describes the development and validation of a sensitive method using solid-phase extraction and isotope dilution liquid chromatography/tandem mass spectrometry with multiple reaction monitoring for the concurrent analysis of the major soy isoflavones (genistein and daidzein), an important metabolite of daidzein (equol), tamoxifen, and its important metabolites (4-hydroxytamoxifen, N-desmethyltamoxifen, and 4-hydroxy-N-desmethyltamoxifen or "endoxifen") in the serum of rats and women. The limits of quantification achieved are sufficient to determine accurately and precisely the concentrations of all of these analytes in women consuming soy foods and/or therapeutic doses of tamoxifen at levels consistent with modulation of estrogen receptor-mediated functions. These procedures enable future investigations of the possible impact of diet on the outcome of breast cancer therapy. 相似文献
593.
LIANG Yong-tao MI Hao-yu WANG Ming-zhe YU Li-ya LIU Zhong-hui WANG En-si . College of Life Science Jilin University Changchun P. R. China . Changchun University of Chinese Medicine Changchun . College of Basic Medical Sciences . College of Phamacy 《高等学校化学研究》2009,25(2)
Thymopentin derivative(septapeptide) was prepared by means of the solid-phase peptide synthesis method in which stepwise and segment condensations were involved.The structures of the key intermediate and target molecule were confirmed by ESI-MS,elementary analysis,IR,1H NMR and 13C NMR spectrometries in our experiments.In this study,the authors found that both thymopentin derivetive(septapeptide) and thymopentin could promote T cell proliferation and increase of E-rose fomation cells. 相似文献