Teachers’ gestures and speech in mathematics lessons: forging common ground by resolving trouble spots

This research focused on how teachers establish and maintain shared understanding with students during classroom mathematics instruction. We studied the micro-level interventions that teachers implement spontaneously as a lesson unfolds, which we call micro-interventions. In particular, we focused on teachers’ micro-interventions around trouble spots, defined as points during the lesson when students display lack of understanding. We investigated how teachers use gestures along with speech in responding to such trouble spots in a corpus of six middle-school mathematics lessons. Trouble spots were a regular occurrence in the lessons (M = 10.2 per lesson). We hypothesized that, in the face of trouble spots, teachers might increase their use of gestures in an effort to re-establish shared understanding with students. Thus, we predicted that teachers would gesture more in turns immediately following trouble spots than in turns immediately preceding trouble spots. This hypothesis was supported with quantitative analyses of teachers’ gesture frequency and gesture rates, and with qualitative analyses of representative cases. Thus, teachers use gestures adaptively in micro-interventions in order to foster common ground when instructional communication breaks down.     

First measurements of inclusive muon neutrino charged current differential cross sections on argon

The ArgoNeuT Collaboration presents the first measurements of inclusive muon neutrino charged current differential cross sections on argon. Obtained in the NuMI neutrino beam line at Fermilab, the flux-integrated results are reported in terms of outgoing muon angle and momentum. The data are consistent with the Monte Carlo expectation across the full range of kinematics sampled, 0°<θ(μ)<36° and 0相似文献   

The Preparation of 1H-Pyrazole-1-carboxylic Acid, 1, 1-Dimethylethyl Esters from Dilithiated C(α), N-Hydrazones of Hydrazinecarboxylic Acid, 1, 1-Dimethylethyl Ester

C(α), N-Hydrazones of hydrazinecarboxylic acid, 1, 1-dimethylethyl ester [C(α), N-carbo-t-butoxyhydrazones] were metalated with excess lithium diisopropylamide, and the dianion-type intermediates were condensed with select aromatic esters followed by acid cyclization to substituted 1H-pyrazole-1-carboxylic acid, 1, 1-dimethylethyl esters (N-carbo-t-butoxypyrazoles).     

A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2

Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivates glucagon-like protein-1. DPP4 also has roles in steatosis, insulin resistance, cancers and inflammatory and fibrotic diseases. In addition, DPP4 binds to the spike protein of the MERS virus, causing it to be the human cell surface receptor for that virus. DPP4 has been identified as a potential binding target of SARS-CoV-2 spike protein, so this question requires experimental investigation. Understanding protein structure and function requires reliable protocols for production and purification. We developed such strategies for baculovirus generated soluble recombinant human DPP4 (residues 29–766) produced in insect cells. Purification used differential ammonium sulphate precipitation, hydrophobic interaction chromatography, dye affinity chromatography in series with immobilised metal affinity chromatography, and ion-exchange chromatography. The binding affinities of DPP4 to the SARS-CoV-2 full-length spike protein and its receptor-binding domain (RBD) were measured using surface plasmon resonance and ELISA. This optimised DPP4 purification procedure yielded 1 to 1.8 mg of pure fully active soluble DPP4 protein per litre of insect cell culture with specific activity >30 U/mg, indicative of high purity. No specific binding between DPP4 and CoV-2 spike protein was detected by surface plasmon resonance or ELISA. In summary, a procedure for high purity high yield soluble human DPP4 was achieved and used to show that, unlike MERS, SARS-CoV-2 does not bind human DPP4.     

Majorization and multiplier sequences

We present applications of matrix methods to the analytic theory of polynomials. We first show how matrix analysis can be used to give new proofs of a number of classical results on roots of polynomials. Then we use matrix methods to establish a new log-majorization result on roots of polynomials. The theory of multiplier sequences gives the common link between the applications.     

Cyclometalated Platinum(II) Complexes with Donor-Acceptor-Containing Bidentate Ligands and Their Application Studies as Organic Resistive Memories

A series of heteroleptic cyclometalated platinum(II) complexes, [Pt(C^N)(O^O)], ( 1 – 10 ) with various donors and acceptors has been synthesized and characterized by ¹H NMR spectroscopy, elemental analyses, infrared spectroscopy and mass spectrometry. The X-ray structure of 2 has also been determined. The electrochemical and photophysical properties of the platinum(II) complexes were studied. These experimental results have been supported by computational studies. Furthermore, two of the complexes have been employed as the active material in the fabrication of resistive memory devices, exhibiting stable binary memory performance with low operating voltage, high ON/OFF ratio and long retention time.     

Forest planning at the tactical level

Forest management and planning can involve large tracts of land involving numerous areal units. One approach to plan activities for a forested region over decades involves breaking down decision making into three components: strategic, tactical, and operational. Each level of the management hierarchy can involve the development and application of optimization models. These models typically aid in exploring management alternatives as well as multi-objective tradeoffs. Even though a strategic model can provide support for long term management at a broad scale, solutions may not be feasible at an operational level. Tactical level modeling helps to bridge solutions reached at a strategic level using operational planning information. This paper presents several tactical level planning models that have been developed as a part of a research effort supported by the US Forest Service. These models have been utilized in land use management and planning by the US Forest Service through a specially developed spatial decision support system.     

Deciphering the Spectral Tuning Mechanism in Proteorhodopsin: The Dominant Role of Electrostatics Instead of Chromophore Geometry

Proteorhodopsin (PR) is a photoactive proton pump found in marine bacteria. There are two phenotypes of PR exhibiting an environmental adaptation to the ocean's depth which tunes their maximum absorption: blue-absorbing proteorhodopsin (BPR) and green-absorbing proteorhodopsin (GPR). This blue/green color-shift is controlled by a glutamine to leucine substitution at position 105 which accounts for a 20 nm shift. Typically, spectral tuning in rhodopsins is rationalized by the external point charge model but the Q105L mutation is charge neutral. To study this tuning mechanism, we employed the hybrid QM/MM method with sampling from molecular dynamics. Our results reveal that the positive partial charge of glutamine near the C₁₄−C₁₅ bond of retinal shortens the effective conjugation length of the chromophore compared to the leucine residue. The derived mechanism can be applied to explain the color regulation in other retinal proteins and can serve as a guideline for rational design of spectral shifts.