Design of fused systems based on σH-adducts of 6-nitro-1,2,4-triazolo[1,5-a]pyrimidine with π-excessive heteroaromatic compounds

Russian Chemical Bulletin - A new method was developed for the construction of tetra- and pentacyclic fused systems based on σH-adducts of 6-nitro-1,2,4-triazolo[1,5-a]pyrimidine with...     

Monitoring of hemodynamics of brain vessels

This paper describes the results of intraoperational monitoring of hemodynamic parameters (velocity and pressure) in brain vessels, carried out within the framework of 50 neurosurgical operations using a Volcano ComboMap instrumental measuring system. It is established that the introduced parameter of specific load used during the neurosurgical operations is a significant parameter for the success of the operation.     

Optimization of the chemical stage of pretreatment of technical polychlorobiphenyls for destruction

The reactions of commercial polychlorobiphenyl mixtures of Sovol and Trikhlorbifenil brands (Russia) with sodium methoxide were studied in dimethyl sulfoxide and methanol. It was shown for the first time that Sovol congeners are exhaustively converted, without formation of potentially toxic products, in the reaction with alkali metal alkoxide based on a monobasic aliphatic alcohol. This process is a stage of chemical pretreatment of polychlorobiphenyls subject to destruction for the subsequent microbiological mineralization of the new derivatives.     

An efficient route to 5-(hetero)aryl-2,4′- and 2,2′-bipyridines through readily available 3-pyridyl-1,2,4-triazines

A new route to substituted bipyridines based on a new method for the synthesis of substituted 3-pyridyl-1,2,4-triazines and their aza-Diels-Alder reactions is shown to be an efficient strategy for the preparation of structurally diverse bipyridine ligands.     

Cyclizations of N-alkyl-substituted azinium cations with bifunctional nucleophiles. 28. Orientation of the nucleophile in the reaction of quinoxalinium salts with indan-1,3-dione

In reactions with quinoxalinium salts in alcoholic-base media indan-1,3-dione acts as a C nucleophile, adding at the 2 or 3 position of the heterocycle to give the corresponding ylidene derivatives; attack by the nucleophile at the C₍₃₎ atom (the position relative to the quaternary nitrogen atom) is preceded by addition of alcohol at the a position. Dissociative substitution at the C₍₂₎ atom in 2-alkoxy-3-(1,3-dioxoindan-2-ylidene)-1,2,3,4-tetrahydroquinoxalines by another nucleophile makes it possible to regard lyate complexes as probable intermediates in cyclizations of 1,4-diazinium salts with dinucleophiles.See [1] for Communication 27.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 667–674, May, 1990.     

S<Stack><Subscript>N</Subscript><Superscript>H</Superscript></Stack> Reaction of lithiated nitronyl nitroxide with quinoline <Emphasis Type="Italic">N</Emphasis>-oxide

The S_N^H reaction of lithiated 4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl 3-oxide with quinoline N-oxide affords 4,4,5,5-tetramethyl-2-(1-oxidoquinolin-2-yl)-4,5-dihydro-1H-imidazole-1-oxyl 3-oxide.