Intelligent stimuli-responsive nano immunomodulators for cancer immunotherapy

Cancer immunotherapy is a revolutionary treatment method in oncology, which uses a human''s own immune system against cancer. Many immunomodulators that trigger an immune response have been developed and applied in cancer immunotherapy. However, there is the risk of causing an excessive immune response upon directly injecting common immunomodulators into the human body to trigger an immune response. Therefore, the development of intelligent stimuli-responsive immunomodulators to elicit controlled immune responses in cancer immunotherapy is of great significance. Nanotechnology offers the possibility of designing smart nanomedicine to amplify the antitumor response in a safe and effective manner. Progress relating to intelligent stimuli-responsive nano immunomodulators for cancer immunotherapy is highlighted as a new creative direction in the field. Considering the clinical demand for cancer immunotherapy, we put forward some suggestions for constructing new intelligent stimuli-responsive nano immunomodulators, which will advance the development of cancer immunotherapy.

Progress relating to intelligent stimuli-responsive nano immunomodulators for cancer immunotherapy is highlighted. Suggestions for constructing new strategies have been put forward, which will advance the clinical development of cancer immunotherapy.     

Mono-Allylation of Gem-Diacetates with Allylsamarium Bromide

Our group have explored the reaction of allylsamarium bromide with a variety of substrates, such as N-(2-aminoalkyl)benzotriazoles1, imines2, nitriles3, diorgano diselenides4, disulfides5, isocyanates6 and nitroalkenes7. Here we wish to report the monoallylation of gem-diacetates with allylsamarium bromide. Gem-diacetates are stable in neutral and basic media, thus they are frequently used to protect aldehydes8. However, the presence of two leaving groups at the same carbon may make carbon …     

Di­methyl 2‐(4‐bromo­phenyl)‐10,11‐di­methoxy‐2,3,7,8‐tetra­hydro­spiro­[azepino[2,1‐a]­iso­quinoline‐3,9′‐fluorene]‐4,5‐di­carboxyl­ate

The title compound, C₃₈H₃₂BrNO₆, is a new photochromic tetra­hydro­azepinoiso­quinoline (THAI). The longest spiro bond [1.589 (4) Å] can be broken very easily by UV light, leading to ring opening. This explains the photochromic behaviour.     

Synthesis of Novel Chiral Diol Ligands for the Enantioselective Reactions

The chiral diols ((,(,((,((-Tetraaryl-1,3-dioxolane-4,5-dimethanols) have been used for the formation of cyclic titanates and similar derivatives of Mg, Al and Zr. These complexes of oxophilic metal centers were employed in catalytic and stiochiometric enantioselective reactions such as enantioselective addition reactions of carbon-centered nucleophiles to aldehydes1, [2+2] cycloadditions2, and Diels-Alder reactions3. So far, the two hydrogen atoms of all this type of diols are in trans form…     

两性树脂解吸动力学的研究──温度对扩散系数的影响

本文采用浅床法对阳离子在弱酸强碱两性树脂相内的扩散速度进行了研究。发现温度升高 ,其粒内扩散系数增大 ,离子价态越高 ,扩散过程的活化能就越大 ,表明温度的改变对高价阳离子的扩散速度的影响更显著     

LC–MS/MS method for the simultaneous determination of ethyl gallate and its major metabolite in rat plasma

A simple, rapid and sensitive liquid chromatography–tandem mass spectroscopy (LC–MS/MS) method was developed and validated for the determination of ethyl gallate, a pharmacologically active constituent isolated from Lagerstroemia speciosa (Linn.) Pers. This method was used to examine the pharmacokinetics of ethyl gallate and its major metabolite gallic acid in rat plasma using propyl gallate as an internal standard. After precipitation of the plasma proteins with acetonitrile, the analytes were separated on a Zorbax SB‐C₁₈ column (3.5 μm, 2.1 × 50 mm) with an isocratic mobile phase consisted of methanol–acetonitrile–10 mM ammonium acetate (10 : 25 : 65, v/v/v) containing 0.1% formic acid at a flow rate of 0.25 mL/min. The Agilent G6410A triple quadrupole LC/MS system was operated under the multiple‐reaction monitoring mode using the electrospray ionization technique in negative mode. The lower limits of quantification of gallic acid and ethyl gallate of the method were 0.5 and 1.0 ng/mL. The intra‐day and inter‐day accuracy and precision of the assay were less than 8.0%. This method has been applied successfully to a pharmacokinetic study involving the intragastric administration of ethyl gallate to rats. Copyright © 2009 John Wiley & Sons, Ltd.     

Synthesis and characterization of green to orange electroluminescent copolymers derived from fluorene and 2,3-dimethylnaphthalopyrazine

Series of high molecular weight, readily soluble copolymers were synthesized by Suzuki palladium catalyzed coupling reaction from 9,9-dioctylfluorene and 2,3-dimethylnaphthopyrazine. The absorption, electrochemical and photoluminescence properties of the copolymers were studied. The external electrolu-minescence efficiencies in the devices of configuration indium-tin oxide/polyethylenedioxythiophene-polystyrene sulfonic acid/poly(fluorene-naphthopyrazine)/barium/aluminium varied with the copolymers composition, and the electroluminescence emission peaks of the copolymers were red-shifted from 530 nm to 584 nm as 2,3-dimethylnaphthopyrazine mole contents increasing from 0.5% to 30%. The best device performance was observed for devices fabricated with the copolymer of 2,3-dimethylnathphpyrazine 5% mole contents, showed maximum external quantum efficiency of 1.38% and electroluminescence peaks at around 537 nm.