Training humans in non-native phoneme perception using a monkey psychoacoustic procedure

Humans were trained to categorize problem non-native phonemes using an animal psychoacoustic procedure that trains monkeys to greater than 90% correct in phoneme identification [Sinnott and Gilmore, Percept. Psychophys. 66, 1341-1350 (2004)]. This procedure uses a manual left versus right response on a lever, a continuously repeated stimulus on each trial, extensive feedback for errors in the form of a repeated correction procedure, and training until asymptotic levels of performance. Here, Japanese listeners categorized the English liquid contrast /r-l/, and English listeners categorized the Middle Eastern dental-retroflex contrast /d-D/. Consonant-vowel stimuli were constructed using four talkers and four vowels. Native listeners and phoneme contrasts familiar to all listeners were included as controls. Responses were analyzed using percent correct, response time, and vowel context effects as measures. All measures indicated nativelike Japanese perception of /r-l/ after 32 daily training sessions, but this was not the case for English perception of /d-D/. Results are related to the concept of "robust" (more easily recovered) versus "fragile" (more easily lost) phonetic contrasts [Burnham, Appl. Psycholing. 7, 207-240 (1986)].     

Plane wave source with minimal harmonic distortion for investigating nonlinear acoustic properties

The objective of this investigation is to introduce and validate a practical ultrasound source to be used in the investigation of the nonlinear material properties of liquids and soft tissues studied in vitro. Methods based on the progressive distortion of finite amplitude ultrasonic waves in the low megahertz frequency range are most easily implemented under the assumption of plane wave propagation. However, achieving an approximately planar ultrasonic field over substantial propagation distances can be challenging. Furthermore, undesired harmonic distortion of the ultrasonic field prior to insonification of the specified region of interest represents another serious limitation. This paper introduces an approach based on the use of the ultrasonic field emanating from a stainless-steel delay line. Both simulation and direct experimental measurement demonstrate that such a field exhibits relatively planar wave fronts to a good approximation (such that a 3-mm-diam receiver would be exposed to no more than 3 dB of loss across its face) and is free from the significant harmonic distortion that would occur in a conventional water path.     

No-slip hydrodynamic boundary condition for hydrophilic particles

We describe measurement and interpretation of the force acting on a smooth hydrophilic glass particle during rapid (1-100 microm s(-1) approach to, and separation from, a hydrophilic glass plate in viscous concentrated aqueous sucrose solutions (0.001 Pa s相似文献   

Study of the mobility,surface area,and sintering behavior of agglomerates in the transition regime by tandem differential mobility analysis

The surface area of nanosized agglomerates is of great importance as the reactivity and health effects of such particles are highly dependent on surface area. Changes in surface area through sintering during nanoparticle synthesis processes are also of interest for precision control of synthesised particles. Unfortunately, information on particle surface area and surface area dynamics is not readily obtainable through traditional particle mobility sizing techniques. In this study, we have experimentally determined the mobility diameter of transition regime agglomerates with 3, 4, and 5 primary particles. Agglomerates were produced by spray drying well-characterised polystyrene latex particles with diameters of 55, 67, 76, and 99 nm. Tandem differential mobility analysis was used to determine agglomerate mobility diameter by selecting monodisperse agglomerates with the same number of primary particles in the first DMA, and subsequently completely sintering the agglomerates in a furnace aerosol reactor. The size distribution of the completely sintered particles was measured by an SMPS system, which allowed for the determination of the number of primary particles in the agglomerates. A simple power law regression was used to express mobility diameter as a function of primary particle size and the number of primary particles, and had an excellent correlation (R² = 0.9971) with the experimental data. A scaling exponent was determined from the experimental data to relate measured mobility diameter to surface area for agglomerates. Using this relationship, the sintering characteristics of agglomerates were also examined for varying furnace temperatures and residence times. The sintering data agreed well with the geometric sintering model (GSM) model proposed by Cho & Biswas (2006a) as well as with the model proposed Koch & Friedlander (1990) for sintering by viscous flow.     

Wall boundary conditions for high-order finite-difference schemes in computational aeroacoustics

High-order finite-difference schemes are less dispersive and dissipative but, at the same time, more isotropic than low-order schemes. They are well suited for solving computational acoustics problems. High-order finite-difference equations, however, support extraneous wave solutions which bear no resemblance to the exact solution of the original partial differential equations. These extraneous wave solutions, which invariably degrade the quality of the numerical solutions, are usually generated when solid-wall boundary conditions are imposed. A set of numerical boundary conditions simulating the presence of a solid wall for high-order finite-difference schemes using a minimum number of ghost values is proposed. The effectiveness of the numerical boundary conditions in producing quality solutions is analyzed and demonstrated by comparing the results of direct numerical simulations and exact solutions.This work was supported by the NASA Lewis Research Center Grant NAG 3-1267 and in part by the NASA Langley Research Center Grant NAG 1-1479 and the Florida State University through time granted on its Cray-YMP Supercomputer.     

A parametric study of droplet deformation through a microfluidic contraction: Shear thinning liquids

Numerical simulations of a droplet passing through an axisymmetric microfluidic contraction are presented, focusing on systems where one of the two liquids present is shear thinning. The simulations are performed using a transient Volume of Fluid (VOF) algorithm. When the droplet is shear thinning and the surrounding phase Newtonian, droplets deform in a similar way to Newtonian droplets that have a viscosity equal to the average viscosity of the shear thinning fluid while it is within the contraction. When the surrounding phase is shear thinning and the droplet Newtonian, droplets deform in a similar way to droplets contained within a Newtonian liquid that has a viscosity that is lower than that of the droplet. In both cases the behaviour of the shear thinning fluid can be broadly described in terms of a ‘characteristic’ Newtonian viscosity: However, determining the exact value of this viscosity without performing a full shear thinning simulation is not possible.     

A comparison of results of axial-tension,rotating-beam and pressurized-cylinder fatigue tests

In a previous paper by Davidson, Eisenstadt and Reiner, it was noted that, as the diameter ratio of an open-end, thick-walled cylinder approached unity, the stress state due to internal pressure approaches that of uniaxial tension. It was, therefore, proposed that the fatigue life of a cyclically pressurized thick-walled cylinder might be predicted from the results of axialtension fatigue tests. In this paper, the results of the thick-walled-cylinder fatigue tests, reported in Ref. 2, extrapolated to a diameter ratio of unity, are compared with the results of axial-tension fatigue tests on the same material. The effect of oil in contact with the surface of the axial fatigue specimens and that of varying the cyclic speed from 1800 cpm to 200 cpm are investigated. Rotating beam fatigue test results for the same material are also reported. The results of the axial-tension fatigue tests do not agree with the extrapolated thick-walled cylinder results in the range of fatigue lives from 10⁴ to 10⁶ cycles with the cylinder results showing the shorter lives. For less than 10⁴ cycles, the results converge. No effect of cyclic speed or of oil in contact with the surface was found. The results of the rotating-beam tests generally lie between the axial-tension and extrapolated cylinder results.     

Polymersomes Prepared from Thermoresponsive Fluorescent Protein–Polymer Bioconjugates: Capture of and Report on Drug and Protein Payloads

Polymersomes provide a good platform for targeted drug delivery and the creation of complex (bio)catalytically active systems for research in synthetic biology. To realize these applications requires both spatial control over the encapsulation components in these polymersomes and a means to report where the components are in the polymersomes. To address these twin challenges, we synthesized the protein–polymer bioconjugate PNIPAM‐b‐amilFP497 composed of thermoresponsive poly(N‐isopropylacrylamide) (PNIPAM) and a green‐fluorescent protein variant (amilFP497). Above 37 °C, this bioconjugate forms polymersomes that can (co‐)encapsulate the fluorescent drug doxorubicin and the fluorescent light‐harvesting protein phycoerythrin 545 (PE545). Using fluorescence lifetime imaging microscopy and Förster resonance energy transfer (FLIM‐FRET), we can distinguish the co‐encapsulated PE545 protein inside the polymersome membrane while doxorubicin is found both in the polymersome core and membrane.     

Ammonia Activation by a Nickel NCN‐Pincer Complex featuring a Non‐Innocent N‐Heterocyclic Carbene: Ammine and Amido Complexes in Equilibrium

A Ni⁰‐NCN pincer complex featuring a six‐membered N‐heterocyclic carbene (NHC) central platform and amidine pendant arms was synthesized by deprotonation of its Ni^II precursor. It retained chloride in the square‐planar coordination sphere of nickel and was expected to be highly susceptible to oxidative addition reactions. The Ni⁰ complex rapidly activated ammonia at room temperature, in a ligand‐assisted process where the carbene carbon atom played the unprecedented role of proton acceptor. For the first time, the coordinated (ammine) and activated (amido) species were observed together in solution, in a solvent‐dependent equilibrium. A structural analysis of the Ni complexes provided insight into the highly unusual, non‐innocent behavior of the NHC ligand.     

Access to Nitriles from Aldehydes Mediated by an Oxoammonium Salt

A scalable, high yielding, rapid route to access an array of nitriles from aldehydes mediated by an oxoammonium salt (4‐acetylamino‐2,2,6,6‐tetramethylpiperidine‐1‐oxoammonium tetrafluoroborate) and hexamethyldisilazane (HMDS) as an ammonia surrogate has been developed. The reaction likely involves two distinct chemical transformations: reversible silyl‐imine formation between HMDS and an aldehyde, followed by oxidation mediated by the oxoammonium salt and desilylation to furnish a nitrile. The spent oxidant can be easily recovered and used to regenerate the oxoammonium salt oxidant.