全文获取类型
收费全文 | 4445篇 |
免费 | 224篇 |
国内免费 | 23篇 |
专业分类
化学 | 3346篇 |
晶体学 | 19篇 |
力学 | 103篇 |
数学 | 603篇 |
物理学 | 621篇 |
出版年
2023年 | 53篇 |
2022年 | 75篇 |
2021年 | 84篇 |
2020年 | 138篇 |
2019年 | 116篇 |
2018年 | 66篇 |
2017年 | 81篇 |
2016年 | 179篇 |
2015年 | 157篇 |
2014年 | 185篇 |
2013年 | 216篇 |
2012年 | 316篇 |
2011年 | 268篇 |
2010年 | 165篇 |
2009年 | 160篇 |
2008年 | 240篇 |
2007年 | 229篇 |
2006年 | 195篇 |
2005年 | 206篇 |
2004年 | 193篇 |
2003年 | 127篇 |
2002年 | 165篇 |
2001年 | 69篇 |
2000年 | 66篇 |
1999年 | 57篇 |
1998年 | 63篇 |
1997年 | 51篇 |
1996年 | 56篇 |
1995年 | 47篇 |
1994年 | 37篇 |
1993年 | 36篇 |
1992年 | 45篇 |
1991年 | 27篇 |
1990年 | 29篇 |
1989年 | 34篇 |
1988年 | 33篇 |
1987年 | 31篇 |
1986年 | 25篇 |
1985年 | 30篇 |
1984年 | 34篇 |
1983年 | 27篇 |
1982年 | 23篇 |
1981年 | 38篇 |
1980年 | 24篇 |
1979年 | 22篇 |
1978年 | 17篇 |
1977年 | 27篇 |
1976年 | 17篇 |
1975年 | 14篇 |
1970年 | 15篇 |
排序方式: 共有4692条查询结果,搜索用时 15 毫秒
91.
Dr. Kaveh Matinkhoo Antonio A. W. L. Wong Dr. Chido M. Hambira Brandon Kato Charlie Wei Dr. Christoph Müller Dr. Torsten Hechler Dr. Alexandra Braun Dr. Francesca Gallo Dr. Andreas Pahl Prof. David M. Perrin 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(40):10282-10292
Alpha-amanitin, an extremely toxic bicyclic octapeptide extracted from the death-cap mushroom, Amanita phalloides, is a highly selective allosteric inhibitor of RNA polymerase II. Following on growing interest in using this toxin as a payload in antibody-drug conjugates, herein we report the synthesis and biochemical evaluation of several new derivatives of this toxin to probe the role of the trans-hydroxyproline (Hyp), which is known to be critical for toxicity. This structure activity relationship (SAR) study represents the first of its kind to use various Hyp-analogs to alter the conformational and H-bonding properties of Hyp in amanitin. 相似文献
92.
In contrast to their carbocyclic aniline analogues, N,N-diarylsubtituted 2-aminothiophenes are not protonated at their N-atoms but at the 5-position or, to a smaller extent, at the 3-position of the thiophene nucleus giving rise to cationic species of the Wheland type. However, 5-formyl and 5-acetyl-substituted 2-(N,N-diarylamino)thiophenes are protonated at the corresponding carbonyl moieties. This finding not only enables insight into the mechanism of electrophilic substitution of N,N-disubstituted 2-aminothiophenes but also allows to prepare deurated 2-aminothiophenes by treatment their non-deuterated parent compounds with CF3COOD. 相似文献
93.
Sodium [2-13C,2-2H3]acetate was incorporated into cytochalasin B( 1 ) by Phoma exigua and into cytochalasin D ( 2 ) by Zygosporium masonii. The 13C-NMR. and 2H-NMR. of the metabolites showed that most of the deuterium was lost except at carbon atoms which are in polyketide chain-initiating units. 相似文献
94.
Constrained peptides are promising next-generation therapeutics. Peptide stapling is a particularly attractive technique to generate constrained macrocycles with improved biological activity and metabolic stability. We introduce a biocompatible two-component stapling approach based on the reagent 2,6-dicyanopyridine and a pseudo-cysteine amino acid. Stapling can proceed either directly on-resin during solid-phase synthesis or following isolation of the linear peptide. The stapling reaction is orthogonal to natural amino acid side chains and completes in aqueous solution at physiological pH, enabling its direct use in biochemical assays. We performed a small screening campaign of short peptides targeting the Zika virus protease NS2B-NS3, allowing the direct comparison of linear with in situ stapled peptides. A stapled screening hit showed over 28-fold stronger inhibition than its linear analogue, demonstrating the successful identification of constrained peptide inhibitors.A synthetically straightforward and biocompatible peptide-stapling strategy that can be used directly in biochemical assays to identify constrained enzyme inhibitors. 相似文献
95.
We present a novel quantum-dynamics approach suitable for computing direct dissociation processes, including electronic transitions. This approach combines quantum trajectories in the Lagrangian reference frame with standard fixed-grid wave packets in order to overcome the limitations and difficulties of both techniques. As a model application, we consider the ultrafast photodissociation of H2 excited by a femtosecond extreme UV laser pulse. 相似文献
96.
Nicoleta E. Mircescu Haibo Zhou Nicolae Leopold Vasile Chiş Natalia P. Ivleva Reinhard Niessner Andreas Wieser Christoph Haisch 《Analytical and bioanalytical chemistry》2014,406(13):3051-3058
Based on molecular-specific surface-enhanced Raman scattering (SERS) spectroscopy we were able to discriminate between rough and smooth strains of Escherichia coli and Proteus mirabilis bacteria. For this purpose, bacteria have been immobilized through electrostatic forces by inducing a positive charge on the glass slide. This way, SERS spectra on bacterial biomass and also on single bacteria could be recorded in less than 2 h, by using concentrated silver nanoparticles as SERS-active substrate. Single-bacterium SERS spectral fingerprints showed to be sensitive to the presence of the O-antigen at strain level and to the microorganisms growth phase. By using principal component analysis (PCA) on the SERS spectra recorded from E. coli and P. mirabilis, these two uropathogens could be fairly discriminated. 相似文献
97.
Cover Picture: Absolute Configuration from Different Multifragmentation Pathways in Light‐Induced Coulomb Explosion Imaging (ChemPhysChem 16/2016) 下载免费PDF全文
Dr. Martin Pitzer Gregor Kastirke Dr. Maksim Kunitski Dr. Till Jahnke Dr. Tobias Bauer Christoph Goihl Florian Trinter Carl Schober Kevin Henrichs Jasper Becht Stefan Zeller Helena Gassert Markus Waitz Andreas Kuhlins Hendrik Sann Felix Sturm Florian Wiegandt Dr. Robert Wallauer Dr. Lothar Ph. H. Schmidt Allan S. Johnson Manuel Mazenauer Benjamin Spenger Sabrina Marquardt Sebastian Marquardt Prof. Dr. Horst Schmidt‐Böcking Prof. Dr. Jürgen Stohner Prof. Dr. Reinhard Dörner Dr. Markus Schöffler Prof. Dr. Robert Berger 《Chemphyschem》2016,17(16):2448-2448
98.
99.
100.