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991.
A simple model to simulate the measurement of layered structures with confocal micro X‐ray fluorescence (micro‐XRF) was developed and implemented as a computer program. The model assumes monochromatic excitation, considers at the moment only K lines, and simplifies the volume defined by excitation and detection foci as a circle area. First simulation results and comparison with data acquired using the Atominstitut confocal micro‐XRF spectrometer are very promising. The simulation software enables us to perform parameter studies to have a better understanding of the analysis of layered structures with confocal micro‐XRF. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
992.
Dr. Víctor García-López Dr. Michal Zalibera Dr. Nils Trapp Dr. Martin Kuss-Petermann Prof. Dr. Oliver S. Wenger Prof. Dr. François Diederich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(50):11451-11461
Resorcin[4]arene cavitands, equipped with diverse quinone ( Q ) and [Ru(bpy)2dppz]2+ (bpy=2,2′-bipyridine, dppz=dipyrido[3,2-a:2′,3′-c]phenazine) photosensitizing walls in different configurations, were synthesized. Upon visible-light irradiation at 420 nm, electron transfer from the [Ru(bpy)2dppz]2+ to the Q generates the semiquinone ( SQ ) radical anion, triggering a large conformational switching from a flat kite to a vase with a cavity for the encapsulation of small guests, such as cyclohexane and heteroalicyclic derivatives, in CD3CN. Depending on the molecular design, the SQ radical anion can live for several minutes (≈10 min) and the vase can be generated in a secondary process without need for addition of a sacrificial electron donor to accumulate the SQ state. Switching can also be triggered by other stimuli, such as changes in solvent, host–guest complexation, and chemical and electrochemical processes. This comprehensive investigation benefits the development of stimuli-responsive nanodevices, such as light-activated molecular grippers. 相似文献
993.
Guan-Yu Qiao Dr. Shuai Yuan Dr. Jiandong Pang Dr. Heng Rao Christina T. Lollar Prof. Dr. Dongbin Dang Prof. Dr. Jun-Sheng Qin Prof. Dr. Hong-Cai Zhou Prof. Dr. Jihong Yu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(41):18381-18385
Intriguing properties and functions are expected to implant into metal–organic layers (MOLs) to achieve tailored pore environments and multiple functionalities owing to the synergies among multiple components. Herein, we demonstrate a facile one-pot synthetic strategy to incorporate multiple functionalities into stable zirconium MOLs via secondary ligand pillaring. Through the combination of Zr6-BTB (BTB=benzene-1,3,5-tribenzoate) layers and diverse secondary ligands (including ditopic and tetratopic linkers), 31 MOFs with multi-functionalities were systematically prepared. Notably, a metal–phthalocyanine fragment was successfully incorporated into this Zr-MOL system, giving rise to an ideal platform for the selective oxidation of anthracene. The organic functionalization of two-dimensional MOLs can generate tunable porous structures and environments, which may facilitate the excellent catalytic performance of as-synthesized materials. 相似文献
994.
Dr. Raoul De Gasparo Ondrej Halgas Dora Harangozo Dr. Marcel Kaiser Prof. Dr. Emil F. Pai Prof. Dr. R. Luise Krauth-Siegel Prof. Dr. François Diederich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(49):11416-11421
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas’ disease, and leishmaniases. Introduction of a new, lean propargylic vector to a known class of TR inhibitors resulted in the strongest reported competitive inhibitor of Trypanosoma (T.) brucei TR, with an inhibition constant Ki of 73 nm , which is fully selective against human glutathione reductase (hGR). The best ligands exhibited in vitro IC50 values (half-maximal inhibitory concentration) against the HAT pathogen, T. brucei rhodesiense, in the mid-nanomolar range, reaching down to 50 nm. X-Ray co-crystal structures confirmed the binding mode of the ligands and revealed the presence of a HEPES buffer molecule in the large active site. Extension of the propargylic vector, guided by structure-based design, to replace the HEPES buffer molecule should give inhibitors with low nanomolar Ki and IC50 values for in vivo studies. 相似文献
995.
996.
Addressing the Glycine‐Rich Loop of Protein Kinases by a Multi‐Facetted Interaction Network: Inhibition of PKA and a PKB Mimic
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Dr. Birgit S. Lauber Dr. Leo A. Hardegger Alam K. Asraful Bjarte A. Lund Oliver Dumele Dr. Michael Harder Dr. Bernd Kuhn Prof. Dr. Richard A. Engh Prof. Dr. François Diederich 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(1):211-221
Protein kinases continue to be hot targets in drug discovery research, as they are involved in many essential cellular processes and their deregulation can lead to a variety of diseases. A series of 32 enantiomerically pure inhibitors was synthesized and tested towards protein kinase A (PKA) and protein kinase B mimic PKAB3 (PKA triple mutant). The ligands bind to the hinge region, ribose pocket, and glycine‐rich loop at the ATP site. Biological assays showed high potency against PKA, with Ki values in the low nanomolar range. The investigation demonstrates the significance of targeting the often neglected glycine‐rich loop for gaining high binding potency. X‐ray co‐crystal structures revealed a multi‐facetted network of ligand–loop interactions for the tightest binders, involving orthogonal dipolar contacts, sulfur and other dispersive contacts, amide–π stacking, and H‐bonding to organofluorine, besides efficient water replacement. The network was analyzed in a computational approach. 相似文献
997.
Peter Ván Arkadi Berezovski Christina Papenfuss 《Continuum Mechanics and Thermodynamics》2014,26(3):403-420
Governing equations of dissipative generalized solid mechanics are derived by thermodynamic methods in the Piola–Kirchhoff framework using the Liu procedure. The isotropic small-strain case is investigated in more detail. The connection to the Ginzburg–Landau type evolution, dual internal variables, and a thermodynamic generalization of the standard linear solid model of rheology is demonstrated. Specific examples are chosen to emphasize experimental confirmations and predictions beyond less general approaches. 相似文献
998.
Ganesh S. Moorthy Christina Vedar Ahila S. Moorthy Janice L. Prodell Athena F. Zuppa 《Biomedical chromatography : BMC》2019,33(6)
Dexmedetomidine (Dex), a highly selective α2‐adrenergic agonist, is used primarily for the sedation and anxiolysis of adults and children in the intensive care setting. A sensitive and selective assay for Dex in pediatric plasma was developed by employing ultra‐high‐performance liquid chromatography–tandem mass spectrometry with d4‐Dex as an internal standard. Dex was extracted from 0.1 mL of plasma by micro‐elution solid‐phase extraction. Separation was achieved with a Waters XBridge C18 column with a flow rate of 0.3 mL/min using a mobile phase comprising 5 mm ammonium acetate buffer with 0.03% formic acid in water and methanol–acetonitrile (50:50, v/v). The intra‐day precision (coefficient of variation) and accuracy for quality control samples ranged from 1.32 to 8.91% and from 92.8 to 108%, respectively. The inter‐day precision and accuracy ranged from 2.13 to 8.45% and from 97.0 to 104%, respectively. The analytical method showed excellent sensitivity using a small sample volume (0.1 mL) with a lower limit of quantitation of 5 pg/mL. This method is robust and has been successfully employed in a pharmacokinetic study of Dex in neonates and infants postoperative from cardiac surgery. 相似文献
999.
Christina Miskaki Ioannis Moutsios Gkreti-Maria Manesi Konstantinos Artopoiadis Cheng-Yen Chang Egor A. Bersenev Dimitrios Moschovas Dimitri A. Ivanov Rong-Ming Ho Apostolos Avgeropoulos 《Molecules (Basel, Switzerland)》2020,25(23)
The synthesis of two (2) novel triblock terpolymers of the ABC type and one (1) of the BAC type, where A, B and C are chemically different segments, such as polystyrene (PS), poly(butadiene) (PB1,4) and poly(dimethylsiloxane) (PDMS), is reported; moreover, their corresponding molecular and bulk characterizations were performed. Very low dimensions are evident from the characterization in bulk from transmission electron microscopy studies, verified by small-angle X-ray data, since sub-16 nm domains are evident in all three cases. The self-assembly results justify the assumptions that the high Flory–Huggins parameter, χ, even in low molecular weights, leads to significantly well-ordered structures, despite the complexity of the systems studied. Furthermore, it is the first time that a structure/properties relationship was studied for such systems in bulk, potentially leading to prominent applications in nanotechnology and nanopatterning, for as low as sub-10 nm thin-film manipulations. 相似文献
1000.
Filip Bure? Old?ich Pytela Fran?ois Diederich 《Journal of Physical Organic Chemistry》2009,22(2):155-162
Solvent effects on the electronic absorption spectra of donor‐substituted 11,11,12,12‐tetracyano‐9, 10‐anthraquinodimethanes (TCAQs) 1 – 3 have been investigated in 32 well‐selected solvents. These compounds were chosen as model structures for charge‐transfer chromophores featuring second‐ and third‐order nonlinear optical properties. The resulting data were evaluated by means of theoretical models and (semi)empirical correlations determining the optical properties related to electron distribution and polarizability. We found that solvent effects on a polar D‐π‐A system do not depend on the donor/acceptor orientation (HOMO/LUMO localization) but especially on the length of the π‐system in between. The observed solvent effects are described with high accuracy by the applied theoretical models and linear combinations of physical quantities. Solvent polarization, permanent dipole moment, and molar volume substantially affect the longest‐wavelength absorption maxima. Solvent‐induced bathochromic shift resulting from the solvent polarity is described with high accuracy by the Born function. On the other hand, hypsochromic effects of the solvent permanent dipole moment are caused due to the slower reorganization of molecular dipoles compared with the rate of excitation. Solvent polarizability shifts the longest‐wavelength absorption maxima bathochromically with increasing length of the π‐conjugated system. Whereas this effect could be suitably described by the Onsager‐induced polarizability, the orientation polarizability was not found to be important. The solvent molar volume as a hypsochromic shift‐inducing factor is only relevant if the size of the solute and solvent molecules are comparable. If the size of the solute is considerably larger than that of the solvent molecules, the solvent behaves as a ‘shape continuum.’ Copyright © 2008 John Wiley & Sons, Ltd. 相似文献