A theory for grain-size reduction in granular flows of spheres

Summary We derive a kinetic theory for homogeneous granular shear flows of identical spheres in which collisions between particles result in small fractures on their peripheries and, over time, effectively reduce their average diameter. In obtaining statistically averaged constitutive relations for the rates of energy dissipation and mass loss, we employ the integral expression derived by Jenkins and Savage [1983] for the collisional source of a particle property. However, in calculating the stress, we modify their expression for the collisional flux in order to ensure that the stress is symmetric when the particles interact through central forces. The constitutive relations are employed in the balance equations for mass, momentum, and energy in order to predict, for a fixed shear rate and particle number density, the manner in which the solid fraction, granular temperature, and induced stresses vary with time.

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Zusammenfassung Wir entwickeln eine kinetische Theorie für die homogene Scherströmung von identischen Kugeln, in welcher die Zusammenstösse der Teilchen kleine Risse in ihrer Oberfläche verursachen und sich dadurch ihr mittlerer Durchmesser mit der Zeit verringert. Um die statistisch gemittelten konstitutiven Beziehungen für die Energiedissipations- und Massenverlustraten zu erhalten, verwenden wir den von Jenkins und Savage [1983] hergeleiteten Integralausdruck für die von den Kollisionen verursachte Quellenstärke einer Teilchenzustandsgrösse. Bei der Berechnung der Spannung verwenden wir jedoch einen abgeänderten Ausdruck für den Fluss durch Kollision; dadurch wird sichergestellt, dass der Spannungstensor symmetrisch ist, wenn die Kontaktkraft zwischen den Teilchen normal zur Kontaktebene wirkt. Die konstitutiven Beziehungen werden in die Gleichungen für die Erhaltung von Masse, Impuls und Energie eingesetzt, um zu berechnen, wie sich der Festkörperanteil, die Granulartemperatur und die induzierten Spannungen als Funktion der Zeit verändern; der Geschwindigkeitsgradient und die Anzahl Teilchen pro Volumen sind dabei konstant.

     

Induction of differentiation of human leukemia cells by various combinations of cytokines and low-molecular-weight inducers

To explore agents for differentiation therapy of leukemias, various combinations of cytokines and low-molecular-weight inducers were examined for differentiation-inducing activity toward three kinds of human leukemia-derived cell lines. The strongest differentiation inducing activity on promyelocytic HL60 cells and histiocytic U937 cells was obtained by combining recombinant tumor necrosis factor (rTNF), interferon-gamma (IFN-gamma), retinoic acid (RA), and 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3). For myeloblastic ML1 cells, the combination of rTNF, IFN-gamma, and RA had the strongest differentiation-inducing activity.     

Determination of activation effect of Ca(OH)<Subscript>2</Subscript> upon the hydration of BFS and related heat by isothermal calorimeter

Isothermal conduction calorimetry, differential thermal analysis (DTA)–thermogravimetric analysis (TG) analysis, and SEM observations have proved the activation effect of Ca(OH)₂ released from the C₃S hydration upon blast furnace slag (BFS). Five sample mixtures of BFS and C₃S and two samples of pure BFS and C₃S were submitted to reaction with water inside the calorimeter at room temperature. The values of hydration heat were recorded up to 7 days. Samples were stored in humidity during 28 days and then were submitted to DTA–TG and SEM analysis. The effect of Ca(OH)₂ upon heat evolution of sample mixtures has been quantified and its influence upon the formation of new hydrates and microstructure of pastes was evidenced.     

A lab-scale digital acoustic emission system for source location

Experimental Techniques - A PC-based, fully digital and lab-scale acoustic emission system for 3-D source location was set up. To get good results, a sampling rate higher than the Nyquist frequency...     

Analysis of dimeric cyanine–nucleic acid dyes by capillary zone electrophoresis in N,N-dimethylacetamide as non-aqueous organic solvent

A method based on capillary zone electrophoresis is presented for the determination of the purity of commercial dimeric cyanine dyes (TOTO, YOYO, BOBO, all -1 and -3 species, LOLO-1, POPO-1) that are common as fluorescent probes for nucleic acid staining. These dyes are tetracharged cations, and have a strong tendency to interact with negatively charged centres, where they are rapidly adsorbed, especially from aqueous solutions. Thus anionic sites at the capillary wall must be avoided, and aqueous buffers are not suitable. The method introduced here avoids both complications, using non-aqueous N,N-dimethylacetamide as solvent, and suppressing the dissociation of silanol groups at the capillary surface due to selection of acidic separation conditions (20 mmol/l perchloric acid as background electrolyte). The present method enables the determination of the purity of all 10 dyes in less than 15 min. The selectivity of the method allows separation of at least five main and differentiating a number of unresolved minor contaminants as demonstrated in detail for TOTO-3 as an example. Quantitation (with 100% normalisation of the peak areas) of nine lots of this dye results in a purity between 33 and 87%.