Differential inhibition of postnatal brain,spinal cord and body growth by a growth hormone antagonist

Background  

Growth hormone (GH) plays an incompletely understood role in the development of the central nervous system (CNS). In this study, we use transgenic mice expressing a growth hormone antagonist (GHA) to explore the role of GH in regulating postnatal brain, spinal cord and body growth into adulthood. The GHA transgene encodes a protein that inhibits the binding of GH to its receptor, specifically antagonizing the trophic effects of endogenous GH.     

Mass spectra of acid and trisubstituted 1- and 2-adamantyl phosphites

The decomposition of acid and trisubstituted phosphites containing 1- and 2-adamantyl, cyclohexyl, and ethyl groups in various combinations was studied under electron impact. The major directions for the fragmentation of the compounds studied are related to cleavage of the C-O bond, which is accompanied by migration of one or two hydrogen atoms to the phosphorus-containing fragment. Mono-, di-, and triadamantyl phosphites feature the loss of phosphorous acid (in the case of acid phosphites) or alkylphosphorous acid (n the case of trisubstituted phosphites) from the molecular ion, which leads to the generation of a diadamantyl or alkyladamantyl species. In this case, the charge is localized predominantly on the hydrocarbon fragment.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 7, pp. 1676–1678, July, 1990.     

Proposal for chiral-boson search at LHC via their unique new signature

The resonance production of new chiral spin-1 bosons and their detection through the Drell-Yan process at the CERN LHC is considered. Quantitative evaluations of various differential cross sections of the chiral-boson production are made within the CalcHEP package. The new neutral chiral bosons can be observed as a Breit-Wigner resonance peak in the invariant-dilepton-mass distribution, as usual. However, unique new signatures of the chiral bosons exist. First, there is no Jacobian peak in the lepton transverse-momentum distribution. Second, the lepton angular distribution in the Collins—Soper frame for the high on-peak invariant masses of the lepton pairs has a peculiar “swallowtail” shape. The text was submitted by the authors in English.     

The synthesis,structure, and electron density distribution in crystals of 4,5-dihydroxyimidazolidine-2-thiones

1,3-H₂-, 1,3-Me₂-, and 1,3-Et₂-4,5-Dihydroxyimidazolidine-2-thiones were synthesized and their structural peculiarities were studied. A comparative analysis of dihydroxyimidazolidine-2-thione and its carbonyl analog performed in the framework of detailed investigation of the electron density distribution in the corresponding crystals revealed the reason for different number and geometric parameters of the hydrogen bonds formed by the (thio)carbonyl groups in the crystals.     

Bis(acetylaryl) podands in the synthesis of fluorine-containing bis(β-diketones) joined by a polyether spacer

O-Alkylation of 2-acetylphenols with α,ω-dichloro derivatives of oligoethylene glycols in the presence of KOH and Al₂O₃ in DMF gave the corresponding podands. Their condensation with ethyl trifluoroacetate afforded fluorine-containing bis(β-diketones) with the aryl fragments linked by conformationally flexible polyether spacers.     

A reference model for anomalously interacting bosons

A simple reference model for anomalously interacting bosons is proposed and implemented in the CompHEP package. This allows preparing for an experimental search of these bosons at powerful colliders, such as Tevatron and LHC. New signatures and some experimental consequences are shortly considered.     

Measurement Process Automatization of Substances Parameters

The development of the magnetodielectric materials electrodynamic parameters measurement process on ultra-high frequencies sets out in various directions. One of these directions is the measurement operativity raising. It may be achieved by using of automatic or semi-automatic measurement set [1]. Appearance of computers with CPU Pentium (or similar Pentium) and new operating systems (OS/2, MS Windows) allow to significantly expend the possibilities of similar measurement sets, herewith increasing measurement accuracy.This work is the continuation of series works, dedicated to substances parameters measurement [1,2,3].