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101.
The electrical conductivities of (1−x) Li2O · x BaO · 2 SiO2, (1−x) Na2O · x MgO ·2 SiO2, (1−x) Na2O · x CaO · SiO2 and (1−x) Na2O · x BaO · 2SiO2 glasses were measured at temperature ranging from room temperature to 450°C. The transport numbers for Na+ ion in (1−x) Na2O · x BaO · 2 SiO2 glasses were measured. It was found that the alkali ion carried a significant part of the current in these glasses except one that had no alkali ions, and the conductivity decreased markedly as the alkali oxide was substituted by an alkaline earth oxide. The results of conductivity measurements combined with the data hitherto reported on mixed alkali glasses led to the proposal that the so-called mixed alkali effect could be explained on the basis of the independent path model in which it is assumed that cations can move only through vacant sites left by those of the same type. 相似文献
102.
Two new Phlegmarine-type alkaloids, lycoposerramines-V and -W, were isolated from Lycopodium serratum, and their structures including the absolute configuration were established by asymmetric total synthesis involving such key steps as Johnson-Claisen rearrangement, asymmetric allylation, and ring-closing metathesis (RCM)- or SmI(2)-mediated stereoselective piperidine ring construction. 相似文献
103.
Small volume low mechanical stress cytometry using computer-controlled Braille display microfluidics
This paper describes a micro flow cytometer system designed for efficient and non-damaging analysis of samples with small numbers of precious cells. The system utilizes actuation of Braille-display pins for micro-scale fluid manipulation and a fluorescence microscope with a CCD camera for optical detection. The microfluidic chip is fully disposable and is composed of a polydimethylsiloxane (PDMS) slab with microchannel features sealed against a thin deformable PDMS membrane. The channels are designed with diffusers to alleviate pulsatile flow behaviors inherent in pin actuator-based peristaltic pumping schemes to maximize hydrodynamic focusing of samples with minimal disturbances in the laminar streams within the channel. A funnel connected to the microfluidic channel is designed for efficient loading of samples with small number of cells and is also positioned on the chip to prevent physical damages of the samples by the squeezing actions of Braille pins during actuation. The sample loading scheme was characterized by both computational fluidic dynamics (CFD) simulation and experimental observation. A fluorescein solution was first used for flow field investigation, followed by use of fluorescence beads with known relative intensities for optical detection performance calibration. Murine myoblast cells (C2C12) were exploited to investigate cell viability for the sample loading scheme of the device. Furthermore, human promyelocytic leukemia (HL60) cells stained by hypotonic DNA staining buffer were also tested in the system for cell cycle analysis. The ability to efficiently analyze cellular samples where the number of cells is small was demonstrated by analyzing cells from a single embryoid body derived from mouse embryonic stem cells. Consequently, the designed microfluidic device reported in this paper is promising for easy-to-use, small sample size flow cytometric analysis, and has potential to be further integrated with other Braille display-based microfluidic devices to facilitate a multi-functional lab-on-a-chip for mammalian cell manipulations. 相似文献
104.
Selective formation of thecis isomer of the nitridotechnetium(V) complex with 2,2′:6′,2″-terpyridine
T. Takayama S. Oshikiri T. Sekine H. Kudo 《Journal of Radioanalytical and Nuclear Chemistry》1999,239(2):397-400
The reaction of [TcNCl2(PPh3)2] with 2,2′:6′,2″-terpyridine producedcis-[TcNCl2(terpy)] selectively. The resulting complexes were characterized by1H NMR and IR spectroscopy. The geometries of thecis andtrans isomers were estimated by theoretical calculations following a density functional method. Thecis isomer is likely more stable than thetrans one with respect to thetrans influence of the nitrido ligand. Furthermore, the behavior of nitridotechnetium complexes in polar solvents was compared
to Os-analogues. 相似文献
105.
Hiromitsu Takayama 《ChemInform》2002,33(38):258-258
106.
Shinobu Itoh Masayasu Taki Shigehisa Takayama Shigenori Nagatomo Teizo Kitagawa Norio Sakurada Ryuichi Arakawa Shunichi Fukuzumi 《Angewandte Chemie (International ed. in English)》1999,38(18):2774-2776
Profound insights into the catalytic mechanism of galactose oxidase (GO) are offered by new models of the active form of the metalloenzyme. The important role of the CuII center in the oxidation of benzyl alcohol to benzaldehyde by the CuII–phenoxyl radical complex of ligand 1 has been revealed by comparison with the reactivity of the corresponding ZnII–phenoxyl radical complex; py=2-pyridyl. 相似文献
107.
Chiba J Iimura S Yoneda Y Sugimoto Y Horiuchi T Muro F Ochiai Y Ogasawara T Tsubokawa M Iigou Y Takayama G Taira T Takata Y Yokoyama M Takashi T Nakayama A Machinaga N 《Chemical & pharmaceutical bulletin》2006,54(11):1515-1529
A novel series of benzoic acid derivatives as VLA-4 antagonists were synthesized. Optimization, focusing on activity and lipophilicity needed for cell permeability, resulted in the identification of 15b and 15e with good activity (IC50 = 1.6 nM each) and moderate lipophilicity (Log D = 2.0, 1.8). Furthermore, 15e demonstrated efficacy in murine asthma model by an oral dose of 30 mg/kg. 相似文献
108.
The initiation and the propagation of detonation waves in a hemispherical chamber and the imploding shock waves that are the reflected detonation waves at the chamber wall are numerically investigated. The effects of the boundary layer and the non-uniformity of the flow field induced by the detonation wave on the imploding shock stability are examined. It is found that the effect of the boundary layer separation on the chamber wall has the strongest effect on the implosion focus. 相似文献
109.
The three-dimensional (3D) shock wave reflections over two perpendicularly intersecting wedges are numerically studied in
this paper, using the finite volume method which is based on the MUSCL-Hancock interpolation technique and self-adaptive unstructured
mesh. Two kinds of 3D Mach stem structures are demonstrated by the numerical simulations for different shock Mach numbers
and wedge angles. A four-shock or three-shock wave configuration appears in the vicinity of the corner of the wedges. 相似文献
110.
Akihiko Okumura Yasuaki Takada Susumu Watanabe Hiroaki Hashimoto Naoya Ezawa Yasuo Seto Yasuo Takayama Ryoji Sekioka Shintaro Yamaguchi Shintaro Kishi Takafumi Satoh Tomohide Kondo Hisayuki Nagashima Tomoki Nagoya 《Journal of the American Society for Mass Spectrometry》2016,27(7):1219-1226
We propose detecting a fragment ion (Ph2As+) using counter-flow introduction atmospheric pressure chemical ionization ion trap mass spectrometry for sensitive air monitoring of chemical warfare vomiting agents diphenylchloroarsine (DA) and diphenylcyanoarsine (DC). The liquid sample containing of DA, DC, and bis(diphenylarsine)oxide (BDPAO) was heated in a dry air line, and the generated vapor was mixed into the humidified air flowing through the sampling line of a mass spectrometer. Humidity effect on the air monitoring was investigated by varying the humidity of the analyzed air sample. Evidence of the in-line conversion of DA and DC to diphenylarsine hydroxide (DPAH) and then BDPAO was obtained by comparing the chronograms of various ions from the beginning of heating. Multiple-stage mass spectrometry revealed that the protonated molecule (MH+) of DA, DC, DPAH, and BDPAO could produce Ph2As+ through their in-source fragmentation. Among the signals of the ions that were investigated, the Ph2As+ signal was the most intense and increased to reach a plateau with the increased air humidity, whereas the MH+ signal of DA decreased. It was suggested that DA and DC were converted in-line into BDPAO, which was a major source of Ph2As+. 相似文献