Synthesis,Characterization, DNA Binding Studies,Photocleavage, Cytotoxicity and Docking Studies of Ruthenium(II) Light Switch Complexes

A new ligand 3-(1H-imidazo[4,5-f][1,10]phenanthrolin-2yl)phenylboronic acid and its (IPPBA) three ruthenium(II) complexes [Ru(phen)₂(IPPBA)](ClO₄)₂ (1), [Ru(bpy)₂(IPPBA)](ClO₄)₂ (2) and [Ru(dmb)₂(IPPBA)](ClO₄)₂ (3) have been synthesized and characterized by elemental analysis, UV/VIS, IR, ¹H-NMR,¹³C-NMR and mass spectra. The binding behaviors of the three complexes to calf thymus DNA were investigated by absorption spectra, emission spectroscopy, viscosity measurements, thermal denaturation and photoactivated cleavage. The DNA-binding constants for complexes 1, 2 and 3 have been determined to be 7.9?×?10⁵ M^?1, 6.7?×?10⁵ M^?1 and 2.9?×?10⁵ M^?1. The results suggest that these complexes bound to double-stranded DNA in an intercalation mode. Upon irradiation at 365 nm, three ruthenium complexes were found to promote the cleavage of plasmid pBR322 DNA from super coiled form ? to nicked form ??. Further in the presence of Co²⁺, the emission of DNA–Ru(ΙΙ) complexes can be quenched. And when EDTA was added, the emission was recovered. The experimental results show that all three complexes exhibited the “on–off–on” properties of molecular “light switch”. The highest Cytotoxicity potential of the complex1 was observed on the Human alveolar adenocarcinoma (A549) cell line. Good agreement was generally found between the spectroscopic techniques and molecular docked model which provides further evidence of groove binding.     

Structural,electronic, optical,elastic and thermal properties of ZnXAs<Subscript>2</Subscript> (X = Si and Ge) chalcopyrite semiconductors

We report first principles calculations of solid state properties of ZnSiAs₂ and ZnGeAs₂ chalcopyrite semiconductors. The structural properties are calculated using a Full Potential Linearized Augmented Plane Wave method (FP-LAPW) of the Density Functional Theory (DFT). A Generalized Gradient Approximation (GGA) scheme proposed by Wu and Cohen (WC) has been chosen to calculate electronic and optical properties. Optical features such as dielectric functions, refractive indices, extinction coefficient, optical reflectivity, absorption coefficients and optical conductivities were calculated for photon energies up to 30 eV. The elastic constants at equilibrium in tetragonal structure are also determined. Temperature effect on the volume, thermal expansion, heat capacity, Debye temperature, entropy, Grüneisen parameter and bulk modulus were calculated employing the quasi-harmonic Debye model at different temperatures and pressures and the silent results were interpreted. Finally using semi-empirical relation, we determined the hardness of the materials which attributed to different covalent bonding strengths.     

Bianchi Type-II Dark Energy Model in Scale Covariant Theory of Gravitation

Spatially Homogeneous and anisotropic Bianchi type-II space time with variable equation of state (EoS) parameter and constant deceleration parameter has been investigated in scale covariant theory of gravitation formulated by Canuto et al. (Phys. Rev. Lett. 39:429, 1977). With the help of special law of variation for Hubble’s parameter proposed by Bermann (Nuovo Cimento 74B:182, 1983) a dark energy cosmological model is obtained in this theory. We use the power law relation between scalar field ? and scale factor R to find the solutions. Some physical and kinematical properties of the model are also discussed.     

Multiple pure tone noise prediction

This paper presents a fully numerical method for predicting multiple pure tones, also known as “Buzzsaw” noise. It consists of three steps that account for noise source generation, nonlinear acoustic propagation with hard as well as lined walls inside the nacelle, and linear acoustic propagation outside the engine. Noise generation is modeled by steady, part-annulus computational fluid dynamics (CFD) simulations. A linear superposition algorithm is used to construct full-annulus shock/pressure pattern just upstream of the fan from part-annulus CFD results. Nonlinear wave propagation is carried out inside the duct using a pseudo-two-dimensional solution of Burgers? equation. Scattering from nacelle lip as well as radiation to farfield is performed using the commercial solver ACTRAN/TM. The proposed prediction process is verified by comparing against full-annulus CFD simulations as well as against static engine test data for a typical high bypass ratio aircraft engine with hardwall as well as lined inlets. Comparisons are drawn against nacelle unsteady pressure transducer measurements at two axial locations as well as against near- and far-field microphone array measurements outside the duct.     

Temperature sensitivity of long period fiber grating in SMF-28 fiber

In this paper we have presented long period fiber grating (LPFG) as temperature sensor. Temperature based sensors have found a number of applications in commercial and industrial fields. In LPFG based temperature sensors, they respond to shift in various peak resonant wavelengths corresponding to various attenuation bands of the transmission spectrum. Temperature effect on the various attenuation bands of a LPFG have been investigated to create a highly sensitive measurement device. The temperature sensitivities of various attenuation bands of a LPFG over the wavelength region of 1.1–1.7 μm, for a grating period of 280 μm period, are obtained by monitoring the wavelength shift of each peak resonant wavelength with temperature increment of 20 °C, ranging from 0 °C to 100 °C.     

Modify SRS-induced crosstalk with variety of fiber in SCM–WDM transmission links

In this paper, the SRS-induced crosstalk has been evaluated in a SCM–WDM communication links at different modulation frequencies and transmission lengths for variety of fiber. Results show that SRS-induced crosstalk dominates at low frequency. As the dispersion and effective area of fiber (A_eff) decreases, initially the crosstalk remains high and then it decreases with increase in modulation frequency. The present work shows that out of five different types of fiber, standard single mode fiber (SMF) has minimum crosstalk (−78 to −38) dB, (−55 to −33) dB and (−46 to −34) dB at modulation frequencies, transmission lengths and optical powers. Dispersion compensation fiber (DCF) has maximum crosstalk (−60 to −12) dB, (−37 to −12) dB and (−27 to −12) dB at modulation frequencies and transmission lengths.     

Effect of Tin Incorporation on Thermo-Mechanical Properties of Glassy Se80Te20 Alloy

We report an analysis on the hardness behavior of glassy Se80？xTe20Snx alloy. The crucial thermo-mechanical parameters （micro-hardness, volume and formation energy of micro-voids and the modulus of elasticity） are examined. The results indicate that the thermo-mechanical parameters are changed significantly after incorporation of Sn in glassy Se80Te20 alloy.     

Investigation of short‐range structural order in Zr69.5Cu12Ni11Al7.5 and Zr41.5Ti41.5Ni17 glasses,using X‐ray absorption spectroscopy and ab initio molecular dynamics simulations

Short‐range order has been investigated in Zr_69.5Cu₁₂Ni₁₁Al_7.5 and Zr_41.5Ti_41.5Ni₁₇ metallic glasses using X‐ray absorption spectroscopy and ab initio molecular dynamics simulations. While both of these alloys are good glass formers, there is a difference in their glass‐forming abilities (Zr_41.5Ti_41.5Ni₁₇ > Zr_69.5Cu₁₂Ni₁₁Al_7.5). This difference is explained by inciting the relative importance of strong chemical order, icosahedral content, cluster symmetry and configuration diversity.     

Ink‐Jet Printed Nanoparticle Alignment Layers: Easy Design and Fabrication of Patterned Alignment Layers for Nematic Liquid Crystals

Ink‐jet printing of monolayer‐capped gold nanoparticles is introduced as a versatile and highly efficient means to pattern the alignment of nematic liquid crystals. Any homeotropic alignment patterns can be created quickly ranging in size from 30 μm (850 dpi) to several square inches, with high accuracy that does not deteriorate with time. Depending on the alignment underlayer, intermediate configurations between homeotropic and homogeneous are also feasible. Nematic liquid crystals with both positive and negative dielectric anisotropy can be switched by applying a DC or AC electric field in the printed vertical domains with the substrate configuration determining the electro‐optic response.