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21.
Loo Wen-da 《应用数学和力学(英文版)》1981,2(1):79-102
In order to study the boundary conditions of integrated form(91a,d),firstlywe make use of trigonometrical series to express Nξη(0,η),Qξ*(0,η)of(97C,D).Suppose . 相似文献
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Jiang Zhang Rachel R. Ogorzalek Loo Joseph A. Loo 《Journal of the American Society for Mass Spectrometry》2017,28(9):1815-1822
Native mass spectrometry (MS) with electrospray ionization (ESI) has evolved as an invaluable tool for the characterization of intact native proteins and non-covalently bound protein complexes. Here we report the structural characterization by high resolution native top-down MS of human thrombin and its complex with the Bock thrombin binding aptamer (TBA), a 15-nucleotide DNA with high specificity and affinity for thrombin. Accurate mass measurements revealed that the predominant form of native human α-thrombin contains a glycosylation mass of 2205 Da, corresponding to a sialylated symmetric biantennary oligosaccharide structure without fucosylation. Native MS showed that thrombin and TBA predominantly form a 1:1 complex under near physiological conditions (pH 6.8, 200 mM NH4OAc), but the binding stoichiometry is influenced by the solution ionic strength. In 20 mM ammonium acetate solution, up to two TBAs were bound to thrombin, whereas increasing the solution ionic strength destabilized the thrombin–TBA complex and 1 M NH4OAc nearly completely dissociated the complex. This observation is consistent with the mediation of thrombin-aptamer binding through electrostatic interactions and it is further consistent with the human thrombin structure that contains two anion binding sites on the surface. Electron capture dissociation (ECD) top-down MS of the thrombin–TBA complex performed with a high resolution 15 Tesla Fourier transform ion cyclotron resonance (FTICR) mass spectrometer showed the primary binding site to be at exosite I located near the N-terminal sequence of the heavy chain, consistent with crystallographic data. High resolution native top-down MS is complementary to traditional structural biology methods for structurally characterizing native proteins and protein–DNA complexes. 相似文献
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In the present paper a finite layer method is studied for the elastodynamics of transverse isotropic bodies. With this method, semi-infinite soils can be considered as an transverse isotropic half-space, its material functions varying with depth. Dividing the half.space into a series of layers in the direction of depth the material fimetioms in each layer are simulated by exponential fumctions Consequently, the fundamental equations to be solved can be simplified if the fouricr transform with repsect to coordinates is used. We have obtained the relationship between the "layer forces" and "layer displacements". This finite layer method, in fact, can also be called a semi-analytical method. It possesses those advantages as the usual semi-analytical methods do, and can be used to analyse the problem of the interaction between soils and structures. 相似文献
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Gomez ED Barteau KP Wang H Toney MF Loo YL 《Chemical communications (Cambridge, England)》2011,47(1):436-438
Grazing-incidence X-ray diffraction and rocking scans have quantified the structure of poly(3-hexylthiophene) and [6,6]-phenyl-C(61)-butyric acid methyl ester in the active layers of organic solar cells. Our study reveals that the device J(SC) correlates with the local structural development of pure PCBM and, to second order, the extent of out-of-plane P3HT π-stacking. 相似文献
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Xu QC Ng YH Zhang Y Loo JS Amal R Tan TT 《Chemical communications (Cambridge, England)》2011,47(30):8641-8643
We demonstrate a general strategy to prepare Bi(2)WO(6)/Ag/N-TiO(2) film with double visible-light-active components bridged by Ag nanoparticles as an electron shuttle, which exhibits enhanced photocatalytic activity and photoelectrochemical performance under visible light. 相似文献
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Tandem mass spectrometry (MS/MS) of intact, noncovalently-bound protein-ligand complexes can yield structural information on the site of ligand binding. Fourier transform ion cyclotron resonance (FT-ICR) top-down MS of the 29 kDa carbonic anhydrase-zinc complex and adenylate kinase bound to adenosine triphosphate (ATP) with collisionally activated dissociation (CAD) and/or electron capture dissociation (ECD) generates product ions that retain the ligand and their identities are consistent with the solution phase structure. Increasing gas phase protein charging from electrospray ionization (ESI) by the addition of supercharging reagents, such as m-nitrobenzyl alcohol and sulfolane, to the protein analyte solution improves the capability of MS/MS to generate holo-product ions. Top-down proteomics for protein sequencing can be enhanced by increasing analyte charging. 相似文献
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The Infrared spectrum of solid chlorotrifluoromethane (CF3Cl) has been studied and compared with that of matrix-isolated CF3Cl. Crystal field splitting patterns of the strongest modes ν1 and ν4 suggest the crystal structure to be orthorhombic with a C2v factor group and two molecules per unit cell located on Cs sites. 相似文献
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