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31.
Structures of 8-G-1-[p-YC6H4Se(O)]C10H6 [1 (G = H), 2 (G = F), 3 (G = Cl), and 4 (G = Br): Y = H, OMe, OCH2Ph, t-Bu, Me, Cl, and NO2] and (1-C10H7)2SeO (5) are investigated by the X-ray crystallographic analysis. Structures of 1 are all A with regard to the naphthyl group (1 (A)), where the Se-C(Ar) and Se-O bonds are perpendicular to and parallel to the naphthyl plane, respectively. Those of 2-4 are also A. Since structures of 8-G-1-(p-YC6H4Se)C10H6 [7 (G = F), 8 (G = Cl), and 9 (G = Br)] are all B, the results exhibit that B of 7-9 change dramatically to A of 2-4 with the introduction of O atoms. The factor to determine the A structures of 1-4 by O is called O dependence. The origin of the O dependence is the nonbonded np(O)- - -pi(Nap) interaction, which results in CT from np(O) to pi(Nap) since O in 1-4 is highly electron rich due to the polar Se+=O- bond and pi(Nap) acts as an acceptor. There are two types of np(O)'s, npy(O) and npz(O), if the directions of the Se-O bond and the p-orbitals of pi(Nap) are taken in the x- and z-axes, respectively. Double but independent np(O)- - -pi(Nap) interactions in 5 lead to 5 (AA). The conformation of the p-YC6H4Se group in 1 changes depending on Y (Y dependence), although the effect is not strong. The Y dependence is explained on the basis of the magnitude of CT of the np(O)-->pi(Ar) type in 1, in addition to the np(O)- - -pi(Nap) interaction. The structure around the Se=O group in 1 is close to that of 5 (AA), if the accepting ability of the p-YC6H4Se group is similar to that of the naphthyl group. A of 2-4 are further stabilized by the np(G)- - -sigma(Se-O) 3c-4e interactions, which are called G dependence. QC calculations performed on the methyl analogues of 1-4 (11-14, respectively) reproduced the observed structures, supported the above discussion, and revealed the energy profiles. The energy-lowering effect of the O dependence would be close to the G dependence of the nonbonded n(Br)- - -sigma(Se-O) 3c-4e interaction in 14 if the steric repulsion between Br and Se is contained in the G dependence. The value is roughly predicted as 20 kJ mol(-1). The structures of 1-5 are well explained by O, G, and Y dependences. 相似文献
32.
Muramatsu W Tanigawa S Takemoto Y Yoshimatsu H Onomura O 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(16):4850-4853
Nonprotected carbohydrates: The catalytic regioselective thiocarbonylation of carbohydrates by using organotin dichloride under mild conditions was demonstrated. The reaction afforded various deoxy saccharides in high yields and excellent regioselectivity in a minimum number of steps. The regioselectivity of the thiocarbonylation is attributed to the intrinsic character of the carbohydrates based on the stereorelationship of their hydroxy groups (see scheme). 相似文献
33.
Satoko Akashi Koji Takio 《Journal of the American Society for Mass Spectrometry》2001,12(12):5415-1253
The structure of melittin bound to dodecylphosphocholine (DPC) micelles was investigated using hydrogen–deuterium (H/D) exchange in conjunction with collision induced dissociation (CID) in an rf-only hexapole ion guide with electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS). The deuterium incorporation into backbone amide hydrogens of melittin with or without DPC micelles was analyzed at different time points examining the mass of each fragment ion produced by hexapole CID. When melittin existed alone in aqueous solution, more than 80% of amide hydrogens was exchanged within 10 s, and the deuterium content in each fragment ion showed high values throughout the experiments. When melittin was bound to DPC micelles, the percentage of deuterium incorporation into the fragment decreased remarkably at any time point. It increased little by little as the exchange period prolonged, indicating that some stable structure was formed by the interaction with DPC. The results obtained here were consistent with the previous studies on the helical structure of melittin carried out by NMR and CD analyses. The strategy using H/D exchange and MS analysis might be useful for studying structural changes of peptides and proteins caused by phospholipid micelles. It could also be applied to membrane-bound proteins to characterize their structure. 相似文献
34.
Nakanishi W Hayashi S Narahara K Hada M 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(31):9647-9655
Contributions from atomic p(Se), d(Se), and f(Se) orbitals to sigmap(Se) are evaluated for neutral and charged Se*Hn (*=null, +, or -) and some oxides to build the image of the contributions. The effect of methyl and halogen substitutions is also examined employing RrSe*XxOo (*=null, +, or -) where R=H or Me; X=F, Cl, or Br. The p(Se) contributions are larger than 96 % for SeH- (Cinfinityv), SeH2 (C2v), SeH3 + (C3v), SeH3 + (D3h), and SeH4 (Td). Therefore, sigmap(Se) of these compounds can be analyzed based on p(Se). The p(Se) contributions are 79-75 % for SeH4 (TBP), SeH5 + (TBP), SeH5 + (SP), and SeH5 - (SP). Methyl and halogen substitutions increase the contributions by 1-2 % (per Me) and 4-7 % (per X), respectively. The contributions are 92-79 % for H2SeO (Cs), H2SeO2 (C2v), and H4SeO (C2v). The values are similarly increased by the substitutions. Consequently, sigmap(Se) of these compounds can be analyzed based on p(Se) with some corrections by d(Se). The p(Se) contribution of SeH6 (Oh) is 52 %: sigmap(Se: SeH6 (Oh)) must be analyzed based on both p(Se) and d(Se). The contributions for the Me and X derivatives of SeH(6) amount to 86-77 %. Therefore, sigmap(Se) of the derivatives can also be analyzed mainly based on p(Se) with some corrections by d(Se). Contributions from f(Se) are negligible. Contributions from 4p(Se) in vacant orbitals are also considered. A utility program derived from the Gaussian 03 (NMRANAL-NH03G) is applied to evaluate the contributions. 相似文献
35.
Arpansiree Wongmekiat Satoko Yoshimatsu Yuichi Tozuka Kunikazu Moribe Keiji Yamamoto 《Journal of inclusion phenomena and macrocyclic chemistry》2006,56(1-2):29-32
Drugs with poor water solubility were co-ground with cyclodextrins (CDs) to create nanoparticles with improved solubility characteristics. Indomethacin (IDM), furosemide (FRM) and naproxen (NAP) were co-ground with β-CD at the molar ratio of 2:1 (CD:drug). Co-grinding of a drug with CD resulted in not only the formation of drug nanoparticles but also the solubilization of the drug by inclusion complex formation with CD in aqueous media. The nanoparticle fraction of IDM, and FRM from ground mixtures prepared with β-CD was as high as 60–70% while the solubilization fraction was less than 10%. In contrast, β-CD–NAP ground mixture showed a large fraction, 48%, for drug solubilization and only 4% for nanoparticle formation. Furosemide ground mixtures prepared with α-CD, β-CD and γ-CD showed comparatively high nanoparticle fraction while the solubilization fraction was around 10%. Both the nanoparticle fraction and the solubilization fraction were greater in the IDM–β-CD system than those in γ-CD and α-CD systems. The nanoparticle formation of NAP depended on the types of CD used as a co-grinding additive. Naproxen nanoparticles could be prepared by co-grinding NAP and α-CD, while the solubilization of NAP tended to improve when β-CD or γ-CD was used. 相似文献
36.
37.
A crucial enzyme in the biosynthesis of the 2-deoxystreptamine aglycon of clinically important aminocyclitol antibiotics is 2-deoxy-scyllo-inosose synthase (DOIS), which converts ubiquitous D-glucose 6-phosphate (G-6-P) into the specific carbocycle 2-deoxy-scyllo-inosose. Among all the oxygenated carbons of the substrate, C-1, -4, -5, and -6 are directly involved in the chemical transformation. To get insight into the roles of C-2 and C-3 hydroxy groups, 2-deoxy-2-fluoro-, 3-deoxy-3-fluoro-, 2-amino-2-deoxy-, and 3-amino-3-deoxy-D-glucose 6-phosphates (2-F-G-6-P, 3-F-G-6-P, 2-NH(2)-G-6-P, and 3-NH(2)-G-6-P, respectively) were subjected to the DOIS reaction as probe, since a fluorine substituent generally acts as a hydrogen-bond acceptor, and an ammonium functionality derived physiologically from an amino group as a hydrogen-bond donor. Among those tested, 2-F-G-6-P and 3-NH(2)-G-6-P were used as substrates by DOIS and were converted into the corresponding deoxyfluoro- and aminodeoxy-scyllo-inososes, respectively. In contrast, 3-F-G-6-P and 2-NH(2)-G-6-P were inactive in the cyclization reaction. Clearly, DOIS recognizes the G-6-P substrate through specific hydrogen-bonding interactions, i.e., through a hydrogen-donating group for C-2 and an accepting group for C-3 of the substrate. Modeling of DOIS based on the structure of evolutionary-related dehydroquinate synthase is also described. 相似文献
38.
Yarita T Nakajima R Otsuka S Ihara TA Takatsu A Shibukawa M 《Journal of chromatography. A》2002,976(1-2):387-391
A method for the determination of ethanol in alcoholic beverages by high-performance liquid chromatography-flame ionization detection (HPLC-FID) was developed. An FID system could be directly connected to an HPLC system using pure water as a mobile phase. In a durability test using triacontylsilyl (C30)-silica gel stationary phase for 96 h, no significant change in the retention time of four alcohol compounds was observed. So the HPLC separation of alcoholic beverages was carried out on the C30-silica gel stationary phase. On application to the analysis of six kinds of alcoholic beverages, ethanol could be determined accurately by the proposed method. 相似文献
39.
40.
Behavior of Halogen Bonds of the Y−X⋅⋅⋅π Type (X,Y=F,Cl, Br,I) in the Benzene π System,Elucidated by Using a Quantum Theory of Atoms in Molecules Dual‐Functional Analysis 下载免费PDF全文
The nature of halogen bonds of the Y?X‐?‐π(C6H6) type (X, Y=F, Cl, Br, and I) have been elucidated by using the quantum theory of atoms in molecules (QTAIM) dual‐functional analysis (QTAIM‐DFA), which we proposed recently. Asterisks (?) emphasize the presence of bond‐critical points (BCPs) in the interactions in question. Total electron energy densities, Hb( r c), are plotted versus Hb( r c)?Vb( r c)/2 [=(?2/8m)?2ρb( r c)] for the interactions in QTAIM‐DFA, in which Vb( r c) are potential energy densities at the BCPs. Data for perturbed structures around fully optimized structures were used for the plots, in addition to those of the fully optimized ones. The plots were analyzed by using the polar (R, θ) coordinate for the data of fully optimized structures with (θp, κp) for those that contained the perturbed structures; θp corresponds to the tangent line of the plot and κp is the curvature. Whereas (R, θ) corresponds to the static nature, (θp, κp) represents the dynamic nature of the interactions. All interactions in Y?X‐?‐π(C6H6) are classified by pure closed‐shell interactions and characterized to have vdW nature, except for Y?I‐?‐π(C6H6) (Y=F, Cl, Br) and F?Br‐?‐π(C6H6), which have typical hydrogen‐bond nature without covalency. I?I‐?‐π(C6H6) has a borderline nature between the two. Y?F‐?‐π(C6H6) (Y=Br, I) were optimized as bent forms, in which Y‐?‐π interactions were detected. The Y‐?‐π interactions in the bent forms are predicted to be substantially weaker than those in the linear F?Y‐?‐π(C6H6) forms. 相似文献